nach oben

Sleep and Breathing

Erschienen in:

19.01.2018 | Sleep Breathing Physiology and Disorders • Original Article

Quality of life in obstructive sleep apnea is related to female gender and comorbid insomnia

verfasst von: Mehmet Sezai Tasbakan, Canan Gunduz, Sebnem Pirildar, Ozen K. Basoglu

Erschienen in: Sleep and Breathing | Ausgabe 4/2018

Einloggen, um Zugang zu erhalten

Abstract

Purpose

Obstructive sleep apnea (OSA) is a common sleep disorder affecting health-related quality of life (QoL), and OSA severity is not a reliable indicator for QoL. The aim of this study was (1) to evaluate the impact of gender on QoL and (2) to identify the predictors of QoL in OSA patients.

Methods

World Health Organization Quality of Life Scale short form (WHOQOL-Bref) was used for evaluating QoL in OSA patients undergoing polysomnography in sleep laboratory of a university hospital.

Results

Out of 197 patients (age 50.4 ± 12.1 years, AHI 38.5 ± 28.4/h), 139 (70.6%) were men and 79.2% had moderate-to-severe OSA. Female gender, increased BMI, higher Epworth sleepiness score (ESS), and lower oxygen saturations were associated significantly with poor QoL in terms of all domains (physical, psychological, social relationship, and environmental) of WHOQOL-Bref questionnaire. The indicators of OSA severity (AHI and ODI) correlated negatively only with the physical domain. The subjects with comorbid insomnia and OSA had lower physical and social scores than subjects with no insomnia, and women with insomnia had significantly worse QoL scores in all domains than the others. In the multivariate linear regression analysis, female gender, comorbid insomnia, increased sleepiness, and higher BMI were significantly associated with poor QoL.

Conclusions

Female gender, comorbid insomnia, and daytime sleepiness were the outstanding factors affecting health-related QoL negatively in OSA. Besides, the impact of OSA on QoL may be explained by the presence of daytime sleepiness rather than OSA severity.

Peppard PE, Young T, Barnet JH, Palta M, Hagen EW, Hla KM (2013) Increased prevalence of sleep-disordered breathing in adults. Am J Epidemiol 177(9):1006–1014. https://doi.org/10.1093/aje/kws342 CrossRefPubMedPubMedCentral

Garvey JF, Pengo MF, Drakatos P, Kent BD (2015) Epidemiological aspects of obstructive sleep apnea. J Thorac Dis 7(6):920–929PubMedPubMedCentral

Young T, Evans L, Finn L, Palta M (1997) Estimation of the clinically diagnosed proportion of sleep apnea syndrome in middle-aged men and women. Sleep 20(9):705–706CrossRefPubMed

Valipour A, Lothaller H, Rauscher H, Zwick H, Burghuber OC, Lavie P (2007) Gender-related differences in symptoms of patients with suspected breathing disorders in sleep: a clinical population study using the sleep disorders questionnaire. Sleep 30(3):312–319. https://doi.org/10.1093/sleep/30.3.312 CrossRefPubMed

Strohl KP, Redline S (1996) Recognition of obstructive sleep apnea. Am J Respir Crit Care Med 154(2 Pt 1):279–289. https://doi.org/10.1164/ajrccm.154.2.8756795 CrossRefPubMed

Cheshire K, Engleman H, Deary I, Shapiro C, Douglas NJ (1992) Factors impairing daytime performance in patients with sleep apnea/hypopnea syndrome. Arch Intern Med 152(3):538–541. https://doi.org/10.1001/archinte.1992.00400150068012 CrossRefPubMed

Shepertycky MR, Banno K, Kryger MH (2005) Differences between men and women in the clinical presentation of patients diagnosed with obstructive sleep apnea syndrome. Sleep 28(3):309–314PubMed

Baldwin CM, Griffith KA, Nieto FJ, O’Connor GT, Walsleben JA, Redline S (2001) The association of sleep-disordered breathing and sleep symptoms with quality of life in the Sleep Heart Health Study. Sleep 24(1):96–105. https://doi.org/10.1093/sleep/24.1.96 CrossRefPubMed

Lopes C, Esteves AM, LRA B, Tufik S, Mello MT (2008) Relationship between the quality of life and the severity of obstructive sleep apnea syndrome. Braz J Med Biol Res 41(10):908–913. https://doi.org/10.1590/S0100-879X2008005000036 CrossRefPubMed

10.

Lacasse Y, Godbout C, Sériès F (2002) Health-related quality of life in obstructive sleep apnoea. Eur Respir J 19(3):499–503. https://doi.org/10.1183/09031936.02.00216902 CrossRefPubMed

11.

Yang EH, Hla KM, McHorney CA, Havighurst T, Badr MS, Weber S (2000) Sleep apnea and quality of life. Sleep 23(4):535–541CrossRefPubMed

12.

Carr AJ, Higginson IJ (2001) Are quality of life measures patient centred? BMJ 322(7298):1357–1360. https://doi.org/10.1136/bmj.322.7298.1357 CrossRefPubMedPubMedCentral

13.

Development of the World Health Organization WHOQOL-BREF quality of life assessment (1998) The WHOQOL Group. Psychol Med 28(3):551–558CrossRef

14.

Eser E, Fidaner H, Fidaner C, Yalcın Eser S, Elbi HGE (1999) The psychometric properties of WHOQOL-100 and WHOQOL-Bref. Psychiatr Psychol Psychopharmacol 7(Suppl. 2):23–40 (in Turkish)

15.

Izci B, Ardic S, Firat H, Sahin A, Altinors M, Karacan I (2008) Reliability and validity studies of the Turkish version of the Epworth sleepiness scale. Sleep Breath 12(2):161–168CrossRefPubMed

16.

Berry RB, Brooks R, Gamaldo CE, Harding SM, Marcus CL, Vaughn BV, For the American Academy of Sleep Medicine (2012). The AASM manual for the scoring of sleep and associated events: rules, terminology and technical specifications, version 2.0. www.aasmnet. Org, Darien , American Academy of Sleep Medicine

17.

Silva Graciela E, Goodwin James L, Vana Kimberly DQSF (2016) Obstructive sleep apnea and quality of life: comparison of the SAQLI, FOSQ, and SF-36 questionnaires. Southwest J Pulm Crit Care 13(3):137–149. https://doi.org/10.13175/swjpcc082-16 CrossRefPubMedPubMedCentral

18.

Lee LW, Lee SA, Ryu HU, Chung YS, Kim WS (2016) Quality of life in patients with obstructive sleep apnea: relationship with daytime sleepiness, sleep quality, depression, and apnea severity. Chron Respir Dis 13(1):33–39. https://doi.org/10.1177/1479972315606312 CrossRefPubMed

19.

Basoglu OK, Tasbakan MS (2017) Gender differences in clinical and polysomnographic features of obstructive sleep apnea: a clinical study of 2827 patients. Sleep Breath. https://doi.org/10.1007/s11325-017-1482-9 CrossRefPubMed

20.

McCall WV, Harding D, O’Donovan C (2006) Correlates of depressive symptoms in patients with obstructive sleep apnea. J Clin Sleep Med 2(4):424–426PubMed

21.

Mediano O, Barceló A, de la Peña M, Gozal D, Agustí A, Barbé F (2007) Daytime sleepiness and polysomnographic variables in sleep apnoea patients. Eur Respir J 30(1):110–113. https://doi.org/10.1183/09031936.00009506 CrossRefPubMed

22.

Dutt N, Janmeja AK, Mohapatra PR, Singh AK (2013) Quality of life impairment in patients of obstructive sleep apnea and its relation with the severity of disease. Lung India 30(4):289–294. https://doi.org/10.4103/0970-2113.120603 CrossRefPubMedPubMedCentral

23.

Moore P, Bardwell WA, Ancoli-Israel S, Dimsdale JE (2001) Association between polysomnographic sleep measures and health-related quality of life in obstructive sleep apnea. J Sleep Res 10(4):303–308. https://doi.org/10.1046/j.1365-2869.2001.00264.x CrossRefPubMed

24.

Goncalves MA, Paiva T, Ramos E, Guilleminault C (2004) Obstructive sleep apnea syndrome, sleepiness, and quality of life. Chest 125(6):2091–2096. https://doi.org/10.1378/chest.125.6.2091 CrossRefPubMed

25.

Bardwell WA, Moore P, Ancoli-Israel S, Dimsdale JE (2003) Fatigue in obstructive sleep apnea: driven by depressive symptoms instead of apnea severity? Am J Psychiatry 160(2):350–355. https://doi.org/10.1176/appi.ajp.160.2.350 CrossRefPubMed

26.

Means MK, Lichstein KL, Edinger JD, Taylor DJ, Durrence HH, Husain AM, Aguillard RN, Radtke RA (2003) Changes in depressive symptoms after continuous positive airway pressure treatment for obstructive sleep apnea. Sleep Breath 7(1):31–42. https://doi.org/10.1007/s11325-003-0031-x CrossRefPubMed

27.

Kang JM, Kang SG, Cho SJ, Lee YJ, Lee HJ, Kim JE, Shin SH, Park KH, Kim ST (2017) The quality of life of suspected obstructive sleep apnea patients is related to their subjective sleep quality rather than the apnea-hypopnea index. Sleep Breath 21(2):369–375. https://doi.org/10.1007/s11325-016-1427-8 CrossRefPubMed

28.

Pamidi S, Knutson KL, Ghods F, Mokhlesi B (2011) Depressive symptoms and obesity as predictors of sleepiness and quality of life in patients with REM-related obstructive sleep apnea: cross-sectional analysis of a large clinical population. Sleep Med 12(9):827–831. https://doi.org/10.1016/j.sleep.2011.08.003 CrossRefPubMed

29.

(1999) Sleep-related breathing disorders in adults: recommendations for syndrome definition and measurement techniques in clinical research. The Report of an American Academy of Sleep Medicine Task Force. Sleep. 22(5):667–689. https://doi.org/10.1093/sleep/22.5.667

30.

Macey PM, Woo MA, Kumar R, Cross RL, Harper RM (2010) Relationship between obstructive sleep apnea severity and sleep, depression and anxiety symptoms in newly-diagnosed patients. PLoS One 5(4):e10211. https://doi.org/10.1371/journal.pone.0010211 CrossRefPubMedPubMedCentral

31.

Silva GE, An MW, Goodwin JL, Shahar E, Redline S, Resnick H, Baldwin CM, Quan SF (2009) Longitudinal evaluation of sleep-disordered breathing and sleep symptoms with change in quality of life: the Sleep Heart Health Study (SHHS). Sleep 32(8):1049–1057. https://doi.org/10.1093/sleep/32.8.1049 CrossRefPubMedPubMedCentral

32.

Vinnikov D, Blanc PD, Alilin A, Zutler M, Holty J-EC (2017) Fatigue and sleepiness determine respiratory quality of life among veterans evaluated for sleep apnea. Health Qual Life Outcomes 15(1):48. https://doi.org/10.1186/s12955-017-0624-x CrossRefPubMedPubMedCentral

Titel: Quality of life in obstructive sleep apnea is related to female gender and comorbid insomnia
verfasst von: Mehmet Sezai Tasbakan
Canan Gunduz
Sebnem Pirildar
Ozen K. Basoglu
Publikationsdatum: 19.01.2018
Verlag: Springer International Publishing
Erschienen in: Sleep and Breathing / Ausgabe 4/2018
Print ISSN: 1520-9512
Elektronische ISSN: 1522-1709
DOI: https://doi.org/10.1007/s11325-018-1621-y

Leitlinien kompakt für die Innere Medizin

Mit medbee Pocketcards sicher entscheiden.

^{Seit 2022 gehört die medbee GmbH zum Springer Medizin Verlag}

Kostenlos registrieren

Neu im Fachgebiet Innere Medizin

24.04.2024 | DGIM 2024 | Kongressbericht | Nachrichten

Update Innere Medizin

Bestellen Sie unseren Fach-Newsletter und bleiben Sie gut informiert.

Newsletter bestellen

Springer Medizin

Quality of life in obstructive sleep apnea is related to female gender and comorbid insomnia

Abstract

Purpose

Methods

Results

Conclusions

Leitlinien kompakt für die Innere Medizin

Neu im Fachgebiet Innere Medizin

Metformin rückt in den Hintergrund

Myokarditis nach Infekt – richtig schwierig wird es bei Profisportlern

Thrombophiliescreening – Wenn, dann richtig und nur bei therapeutischer Konsequenz

Bei Senioren mit Prostatakarzinom auf Anämie achten!

Update Innere Medizin

Springer Medizin

Abstract

Purpose

Methods

Results

Conclusions

Bitte loggen Sie sich ein, um Zugang zu diesem Inhalt zu erhalten

Weitere Artikel der Ausgabe 4/2018

Validation of Bahasa Malaysia STOP-BANG questionnaire for identification of obstructive sleep apnea

Intermittent nocturnal hypoxia and metabolic risk in obese adolescents with obstructive sleep apnea

Effect of CPAP therapy on liver disease in patients with OSA: a review

Basal sympathetic predominance in periodic limb movements in sleep after continuous positive airway pressure

Impact of sleep-related breathing disorder on motor and non-motor symptoms in multiple system atrophy

Neutrophil-to-lymphocyte ratio decreases in obstructive sleep apnea treated with mandibular advancement devices

Leitlinien kompakt für die Innere Medizin

Neu im Fachgebiet Innere Medizin

Metformin rückt in den Hintergrund

Myokarditis nach Infekt – richtig schwierig wird es bei Profisportlern

Thrombophiliescreening – Wenn, dann richtig und nur bei therapeutischer Konsequenz

Bei Senioren mit Prostatakarzinom auf Anämie achten!

Update Innere Medizin