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01.12.2015 | Research article | Ausgabe 1/2015 Open Access

BMC Urology 1/2015

Quality-of-life outcomes and unmet needs between ileal conduit and orthotopic ileal neobladder after radical cystectomy in a Chinese population: a 2-to-1 matched-pair analysis

Zeitschrift:
BMC Urology > Ausgabe 1/2015
Autoren:
Yi Huang, Xiuwu Pan, Qiwei Zhou, Hai Huang, Lin Li, Xingang Cui, Guodong Wang, Ren Jizhong, Lei Yin, Danfeng Xu, Yi Hong
Wichtige Hinweise

Electronic supplementary material

The online version of this article (doi:10.​1186/​s12894-015-0113-7) contains supplementary material, which is available to authorized users.
Yi Huang, Xiuwu Pan and Qiwei Zhou contributed equally to this work.

Competing interest

The authors declare that they have no competing interests.

Authors’ contributions

YH (Huang), XP and QZ designed the study. YH (Huang), XP, QZ, HH, LL, JR, LY, DX and YH (Hong) acquired the data. YH (Huang), XP and QZ did the statistical analysis of the data. YH (Huang), XP, QZ, HH and LL interpreted the data. YH (Huang), XP and QZ drafted the manuscript. XC and GW provided a critical revision of the manuscript. All authors read and approved the final manuscript.

Abstract

Background

Health-related quality-of-life (HRQoL) is an important consideration after radical cystectomy (RC). Lack of effective ways to assess HRQoL after RC and unawareness of disease-specific problems related to ileal conduit (IC) and orthotopic ileal neobladder (OIN) are serious problems. The present study was to evaluate and compare morbidity and HRQoL between IC and OIN after RC, and examine their unmet needs in the two groups.

Methods

A retrospective analysis was made of 294 patients treated with RC in our hospital between 2007 and 2013. Matched pair analysis was used to determine the patients of IC and OIN groups. Patient HRQoL between IC and OIN groups was assessed using the bladder-specific bladder cancer index (BCI) and European Organization for Research and Treatment of Cancer Body Image scale (BIS) questionnaires. Unmet information of patients undergoing these two urinary diversions was recorded through individual interviews.

Results

Of the 117 included patients, 39 patients were treated with OIN and the other 78 matched patients with IC as controls for matched pair analysis. There was no significant difference in baseline characteristics between the two groups. OIN patients showed significantly better BIS scores in terms of HRQoL outcomes after RC at a short-term (<1 year) follow-up level, but there was no significant difference at a long-term (>1 year) follow-up level between the two groups. Interestingly, urinary bother (UB) and urinary function (UF) were poor in OIN patients at the one-year follow-up level, but there was no significant difference in UB between the two groups at the long term follow-up level. Unmet needs analysis showed that OIN patients had a more positive attitude towards treatment and participated in physical and social activities more positively, although they may have more urine leakage problems.

Conclusions

The mean BIS score in OIN group patients was significantly better than that in IC group patients at the one-year follow-up level, but there was no significant difference at the long-term follow-up level. Due attention should be paid to some particular unmet needs in individual patients in managing the two UD modalities.
Zusatzmaterial
Additional file 1: Table S5. Peri-operative outcomes. (DOCX 15 kb)
12894_2015_113_MOESM1_ESM.docx
Additional file 2: Table S6. Continence outcomes following OIN. (DOCX 15 kb)
12894_2015_113_MOESM2_ESM.docx
Additional file 3: Table S1. Demographics and clinical characteristics data before matched pair analysis. (DOCX 19 kb)
12894_2015_113_MOESM3_ESM.docx
Additional file 4: Table S2. Unmet informational and supportive care needs at the time of diagnosis. (DOCX 19 kb)
12894_2015_113_MOESM4_ESM.docx
Additional file 5: Table S3. Unmet informational and supportive care needs following surgery. (DOCX 18 kb)
12894_2015_113_MOESM5_ESM.docx
Additional file 6: Table S4. Unmet informational and support needs during survivorship. (DOCX 18 kb)
12894_2015_113_MOESM6_ESM.docx
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