Background
Methods
FDG-pet/CT
Reference standard
Image interpretation
Semi-quantitative analysis
Statistical analysis
Results
Patient characteristics | Mean ± SD, range |
---|---|
Patient age (years) | 62 ± 4.2 [57;74] |
Body mass index | 27 ± 7.1 [22;32] |
Blood glucose level (mmol/L) | 5.4 ± 1.0 [3.8;7.7] |
Years since treatment of primary breast cancer | 6 ± 8.2 [0;30] |
Scanning characteristics | |
Dose (MBq) | 281 ± 56.0 [208;401] |
Time (min) between injection and early scan (1h) | 62 ± 6.0 [53;80] |
Time (min) between injection and late scan (3h) | 180 ± 6.0 [170;200] |
Sites of recurrence | Number of patients | Number of lesions | Number of biopsies |
---|---|---|---|
Local recurrence | 19 | 21 | 19 |
Distant recurrence | 22 | 316 | 22 |
Cerebrum | 1 | 1 (0.3%) | 1 |
Lung | 6 | 25 (7.4%) | 1 |
Liver | 4 | 7 (2.1%) | 3 |
Breast | 23 | 27 (8.0%) | 21 |
Lymph node | 13 | 54 (16.0%) | 8 |
Bone | 18 | 213 (63.2%) | 7 |
Other | 2 | 10 (3.0%) | 5 |
Local vs. distant recurrence
1h | 3h | ∆SUV (3h-1h) | p-value | ∆SUV% | |
---|---|---|---|---|---|
All 41 patients with recurrence (337 lesions) | |||||
SUVmax | 6.4 ± 3.4 [0.9-19.7] | 8.1 ± 4.4 [0.7-29.7] | 1.8 [1.5 to 2.1] | < 0.0001 | 28 |
SUVmean | 4.0 ± 2.0 [0.5-11.3] | 5.1 ± 2.6 [0.4-16.5] | 1.1 [1.0 to 1.3] | < 0.0001 | 28 |
cSUVmean | 6.5 ± 3.5 [0.7-20.8] | 8.8 ± 4.7 [0.5-30.9] | 2.3 [1.9 to 2.6] | < 0.0001 | 35 |
MTV (cc) | 12.5 ± 42.4 [0.3-562] | 10.4 ± 39.9 [0.2-565.5] | −2.1 [− 3.1 to − 1.0] | < 0.0001 | − 17 |
19 patients with local recurrence (21 lesions) | |||||
SUVmax | 3.0 ± 1.9 [0.9-8.7] | 3.8 ± 3.0 [0.7-12.3] | 0.8 [0.2 to 1.4] | 0.006 | 27 |
SUVmean | 1.9 ± 1.3 [0.5-5.9] | 2.4 ± 2.0 [0.4-8.6] | 0.5 [0.08 to 0.9] | 0.022 | 25 |
cSUVmean | 3.2 ± 2.4 [0.7-8.9] | 4.4 ± 3.9 [0.5-14.4] | 1.2 [0.3 to 2.1] | 0.014 | 36 |
MTV (cc) | 8.4 ± 10.3 [0.3-33.3] | 5.7 ± 5.5 [0.2-22.3] | −2.8 [−6.2 to 0.7] | 0.11 | −33 |
22 patients with distant recurrence (316 lesions) | |||||
SUVmax | 6.6 ± 3.3 [1.2-19.7] | 8.4 ± 4.4 [1.2-29.7] | 1.8 [1.5 to 2.2] | < 0.0001 | 28 |
SUVmean | 4.1 ± 2.0 [0.8-11.3] | 5.3 ± 2.6 [0.6-16.5] | 1.2 [1.0 to 1.4] | < 0.0001 | 28 |
cSUVmean | 6.7 ± 3.5 [0.8-20.8] | 9.1 ± 4.6 [0.8-30.9] | 2.3 [2.0 to 2.7] | < 0.0001 | 35 |
MTV (cc) | 12.8 ± 43.7 [0.4-562.0] | 10.7 ± 41.1 [0.2-565.5] | −2.1 [−3.2 to −0.9] | 0.001 | −16 |
Changes by lesion subgroup
Partial volume correction
Group | Difference 1h (cSUVmean-SUVmean) | p-value | % diff | Difference 3h (cSUVmean-SUVmean) | p-value | % diff |
---|---|---|---|---|---|---|
All lesions (337 lesions) | 2.51 [2.14 – 2.88] | < 0.0001 | 63 | 3.64 [3.22 – 4.06] | < 0.0001 | 71 |
Local recurrence (21 lesions) | 1.32 [0.74 – 1.91] | < 0.0001 | 70 | 2.02 [1.07 - 2.98] | < 0.0001 | 84 |
Distant recurrence (316 lesions) | 2.59 [2.21 - 2.98] | < 0.0001 | 63 | 3.75 [3.32 - 4.18] | < 0.0001 | 71 |
Lung (25 lesions) | 1.88 [0.48 – 3.27] | 0.018 | 60 | 3.09 [1.28 - 4.91] | 0.007 | 68 |
Liver (7 lesions) | 2.17 [−0.80 – 5.14] | 0.103 | 39 | 2.67 [0.91 - 4.44] | 0.017 | 41 |
Breast (27 lesions) | 1.09 [0.59 - 1.60] | < 0.0001 | 63 | 1.86 [1.06 - 2.66] | < 0.0001 | 87 |
Lymph node (54 lesions) | 2.77 [1.62 - 3.92] | < 0.0001 | 69 | 4.49 [3.16 - 5.82] | < 0.0001 | 82 |
Bone (213 lesions) | 2.73 [2.43 - 2.92] | < 0.0001 | 63 | 3.80 [3.45 - 4.14] | < 0.0001 | 69 |
Other (10 lesions) | 2.32 [−21.82 – 26.46] | 0.437 | 78 | 2.73 [−21.54 – 27.00] | 0.389 | 73 |