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Molecular Imaging and Biology
Erschienen in:

07.12.2018 | Research Article

Quantification of Positron Emission Tomography Data Using Simultaneous Estimation of the Input Function: Validation with Venous Blood and Replication of Clinical Studies

verfasst von: Elizabeth A. Bartlett, Mala Ananth, Samantha Rossano, Mengru Zhang, Jie Yang, Shu-fei Lin, Nabeel Nabulsi, Yiyun Huang, Francesca Zanderigo, Ramin V. Parsey, Christine DeLorenzo

Erschienen in: Molecular Imaging and Biology | Ausgabe 5/2019

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Abstract

Purpose

To determine if one venous blood sample can substitute full arterial sampling in quantitative modeling for multiple positron emission tomography (PET) radiotracers using simultaneous estimation of the input function (SIME).

Procedures

Participants underwent PET imaging with [11C]ABP688, [11C]CUMI-101, and [11C]DASB. Full arterial sampling and additional venous blood draws were performed for quantification with the arterial input function (AIF) and SIME using one arterial or venous (vSIME) sample.

Results

Venous and arterial metabolite-corrected plasma activities were within 6 % of each other at varying time points. vSIME- and AIF-derived outcome measures were in good agreement, with optimal sampling times of 12 min ([11C]ABP688), 90 min ([11C]CUMI-101), and 100 min ([11C]DASB). Simulation-based power analyses revealed that SIME required fewer subjects than the AIF method to achieve statistical power, with significant reductions for [11C]CUMI-101 and [11C]DASB with vSIME. Replication of previous findings and test-retest analyses bolstered the simulation analyses.

Conclusions

We demonstrate the feasibility of AIF recovery using SIME with one venous sample for [11C]ABP688, [11C]CUMI-101, and [11C]DASB. This method simplifies PET acquisition while allowing for fully quantitative modeling, although some variability and bias are present with respect to AIF-based quantification, which may depend on the accuracy of the single venous blood measurement.
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Metadaten
Titel
Quantification of Positron Emission Tomography Data Using Simultaneous Estimation of the Input Function: Validation with Venous Blood and Replication of Clinical Studies
verfasst von
Elizabeth A. Bartlett
Mala Ananth
Samantha Rossano
Mengru Zhang
Jie Yang
Shu-fei Lin
Nabeel Nabulsi
Yiyun Huang
Francesca Zanderigo
Ramin V. Parsey
Christine DeLorenzo
Publikationsdatum
07.12.2018
Verlag
Springer International Publishing
Erschienen in
Molecular Imaging and Biology / Ausgabe 5/2019
Print ISSN: 1536-1632
Elektronische ISSN: 1860-2002
DOI
https://doi.org/10.1007/s11307-018-1300-1

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