Quantification of vascular changes in macular telangiectasia type 2 with AngioTool software
- 27.04.2024
- Retinal Disorders
Erschienen in:
- Verfasst von
- Indu Govindaraj
- Maanasi Mahalingam
- Uma Maheswari
- H. S. Yeshwanth Kumar
- B. S. Suganya
- Vishnu Subramanian
- Anand Rajendran
Abstract
Purpose
To compare AngioTool (AT) vascular parameters (VP) between MacTel2 eyes and normal eyes. Secondary outcome measures were to correlate VP with BCVA and to analyze VP between various grades of Simple MacTel Classification.
Methods
This is a retrospective study. SD OCTA images of the superficial vascular complex (SVC) and deep capillary complex (DVC) were exported into Image J and AT. The explant area (EA), vessel area (VA), vessel percentage area (VPA), total number of junctions (TNJ), junction density (JD), total vessel length (TVL), average vessel length (AVL), total number of endpoints (TNE) and mean E lacunarity (MEL) were studied.
Results
Group 1 had 120 MacTel2 eyes. Group 2 had 60 age-matched normal eyes. All VP were significantly different between the two groups except EA and TNE in both complexes. None of the VP had a correlation with BCVA. Interquadrant analysis (IQA) in SVC and DVC showed statistical significance in VPA, AVL and JD and in AVL, TNE, JD, VPA respectively. Post hoc analysis in SVC and DVC showed statistical significance in TNJ, JD, TVL and AVL between grade 1 and grade 3, and in VA, VPA, TNJ, JD, TVL and MEL between grade 0 and grade 3 respectively.
Conclusion
VP were affected in MacTel2 eyes. VP did not correlate with BCVA. Occurrence of pigmentation is an important event in the progression of disease. AT may provide quantitative markers to measure disease progression.
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- Titel
- Quantification of vascular changes in macular telangiectasia type 2 with AngioTool software
- Verfasst von
-
Indu Govindaraj
Maanasi Mahalingam
Uma Maheswari
H. S. Yeshwanth Kumar
B. S. Suganya
Vishnu Subramanian
Anand Rajendran
- Publikationsdatum
- 27.04.2024
- Verlag
- Springer Berlin Heidelberg
- Erschienen in
-
Graefe's Archive for Clinical and Experimental Ophthalmology / Ausgabe 10/2024
Print ISSN: 0721-832X
Elektronische ISSN: 1435-702X - DOI
- https://doi.org/10.1007/s00417-024-06487-w
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