Quantified motility assessment in paediatric inflammatory bowel disease: a multi-reader study
- 07.06.2025
- Research
Erschienen in:
- Verfasst von
- Riwa Meshaka
- Heather E Fitzke
- Joy Barber
- Chloe Foster
- Catriona Reid
- Emma Allan
- Rebecca Murphy
- Kelsey Jones
- Stuart A Taylor
- Tom A Watson
- Erschienen in
- Pediatric Radiology | Ausgabe 7/2025
Abstract
Background
Quantitative bowel motility in inflammatory bowel disease using magnetic resonance enterography (MRE) shows promise as a biomarker of disease activity against histopathological and biochemical markers of inflammation when used by experienced readers in a research setting.
Objective
The aim of this study was to test multi-reader agreement in quantified bowel motility by non-experienced readers.
Materials and methods
A single-centre, retrospective search included all patients <18 years with paediatric inflammatory bowel disease and more than one MRE between 2012-2022. Cine images from the first two MREs were processed using quantified motility software. Two experienced readers provided a reference standard for response using a consensus sMaRIA (decrease of ≥2 points) and measured the change (Δ) in motility index. Two senior and three junior readers visually assessed response for each patient and recorded Δ motility index. Inter-reader agreement was assessed for each pair of readers as the Bland-Altman bias and limits of agreement for Δ motility index (arbitrary units, a.u.) and %agreement in the Δdirection.
Results
Percentage agreement in the Δdirection was fair to excellent. Junior reader agreement with experienced readers was 73-84%, and senior reader agreement with experienced readers was 67-85%. Bland-Altman plots of Δ motility index demonstrated no systematic bias and the junior-experienced readers’ limits of agreement were acceptable.
Conclusion
Quantified bowel motility in paediatric inflammatory bowel disease measured by readers of varied experience yields good agreement.
Graphical Abstract
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- Titel
- Quantified motility assessment in paediatric inflammatory bowel disease: a multi-reader study
- Verfasst von
-
Riwa Meshaka
Heather E Fitzke
Joy Barber
Chloe Foster
Catriona Reid
Emma Allan
Rebecca Murphy
Kelsey Jones
Stuart A Taylor
Tom A Watson
- Publikationsdatum
- 07.06.2025
- Verlag
- Springer Berlin Heidelberg
- Erschienen in
-
Pediatric Radiology / Ausgabe 7/2025
Print ISSN: 0301-0449
Elektronische ISSN: 1432-1998 - DOI
- https://doi.org/10.1007/s00247-025-06273-8
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