Quantile regression-based prediction of intraoperative blood loss in patients with spinal metastases: model development and validation
- 28.04.2023
- Original Article
Erschienen in:
- Verfasst von
- Jikai Li
- Jingyu Zhang
- Xiaozhao Zhang
- Dengxing Lun
- Ruifeng Li
- Rongxing Ma
- Yongcheng Hu
- Erschienen in
- European Spine Journal | Ausgabe 7/2023
Abstract
Purpose
To develop and evaluate a quantile regression-based blood loss prediction model for open surgery of spinal metastases.
Methods
This was a multicenter retrospective cohort study. Over a 11-year period, patients underwent open surgery for spinal metastases at 6 different institutions were reviewed. The outcome measure is intraoperative blood loss (in mL). The effects of baseline, histology of primary tumor and surgical procedure on blood loss were evaluated by univariate and multivariate analysis to determine the predictors. Multivariate ordinary least squares (OLS) regression and 0.75 quantile regression were used to establish two prediction models. The performance of the two models was evaluated in the training set and the test set, respectively.
Results
528 patients were included in this study. Mean age was 57.6 ± 11.2 years, with a range of 20–86 years. Mean blood loss was 1280.1 ± 1181.6 mL, with a range of 10 ~ 10,000 mL. Body mass index (BMI), tumor vascularization, surgical site, surgical extent, total en bloc spondylectomy and microwave ablation use were significant predictors of intraoperative blood loss. Hypervascular tumor, higher BMI, and broader surgical extent were related with massive blood loss. Microwave ablation is more beneficial in surgery with substantial blood loss. Compared to the OLS regression model, the 0.75 quantile regression model may decrease blood loss underestimate.
Conclusion
In this study, we developed and evaluated a prediction model for blood loss in open surgery for spinal metastases based on 0.75 quantile regression, which may minimize blood loss underestimate.
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- Titel
- Quantile regression-based prediction of intraoperative blood loss in patients with spinal metastases: model development and validation
- Verfasst von
-
Jikai Li
Jingyu Zhang
Xiaozhao Zhang
Dengxing Lun
Ruifeng Li
Rongxing Ma
Yongcheng Hu
- Publikationsdatum
- 28.04.2023
- Verlag
- Springer Berlin Heidelberg
- Erschienen in
-
European Spine Journal / Ausgabe 7/2023
Print ISSN: 0940-6719
Elektronische ISSN: 1432-0932 - DOI
- https://doi.org/10.1007/s00586-023-07653-0
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