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European Archives of Oto-Rhino-Laryngology

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01.06.2020 | Otology

Quantitative assessment of cochlear and vestibular ganglion neurons in temporal bones with chronic otitis media

verfasst von: Rafael da Costa Monsanto, Norma de Oliveira Penido, Mio Uchiyama, Patricia Schachern, Michael M. Paparella, Sebahattin Cureoglu

Erschienen in: European Archives of Oto-Rhino-Laryngology | Ausgabe 2/2021

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Abstract

Purpose

In this study, we aimed to determine whether or not COM leads to loss of spiral and Scarpa ganglion neurons.

Methods

From the human temporal bone (HTB) collection at the University of Minnesota we selected human temporal bones with COM, defined as the presence of clinically intractable tissue abnormalities in the middle ear (cholesteatoma, perforation of the eardrum, granulation tissue, fibrosis, tympanosclerosis, and cholesterol granuloma). We also selected HTBs from donors with no ear diseases as controls. We quantitatively analyzed the number of spiral and Scarpa ganglion cells and compared the results obtained in the control and study groups.

Results

In both COM and control groups we observed a significant negative correlation between age and number of both spiral (R = -0.632; P < 0.001; 95% CI − 0.766 to − 0.434) and Scarpa ganglion (R = − 0.404; P = 0.008; 95% CI − 0.636 to − 0.051) cells. We did not find any significant differences in the number of spiral ganglion cells (in total or per segment) or in the density of Scarpa ganglion cells (in each vestibular nerve or both) in the COM group as compared with controls (P > 0.05).

Conclusions and relevance

Our results did not demonstrate significant loss of cochlear or vestibular peripheral ganglion neuron loss in HTBs with COM as compared with controls.

Monasta L, Ronfani L, Marchetti F et al (2012) Burden of disease caused by otitis media: systematic review and global estimates. PLoS ONE 7:e36226. https://doi.org/10.1371/journal.pone.0036226CrossRefPubMedPubMedCentral

de Penido NO, Chandrasekhar SS, Borin A et al (2016) Complications of otitis media: a potentially lethal problem still present. Braz J Otorhinolaryngol 82:253–262. https://doi.org/10.1016/j.bjorl.2015.04.007CrossRef

Cordeiro FP, da Costa Monsanto R, Kasemodel ALP et al (2018) Extended high-frequency hearing loss following the first episode of otitis media. Laryngoscope 128:2879–2884. https://doi.org/10.1002/lary.27309CrossRefPubMed

Tucci DL, Wilson BS, O’Donoghue GM (2017) The growing—and now alarming—burden of hearing loss worldwide. Otol Neurotol 38:1387. https://doi.org/10.1097/MAO.0000000000001593CrossRefPubMed

Aarhus L, Tambs K, Hoffman HJ, Engdahl B (2016) Childhood otitis media is associated with dizziness in adulthood: the HUNT cohort study. Eur Arch Otorhinolaryngol 273:2047–2054. https://doi.org/10.1007/s00405-015-3764-9CrossRefPubMed

Aarhus L, Homøe P, Engdahl B (2020) Otitis media in childhood and disease in adulthood: a 40-year follow-up study. Ear Hear 41:67–71. https://doi.org/10.1097/AUD.0000000000000729CrossRefPubMed

Paparella MM, Oda M, Hiraide F, Brady D (1972) Pathology of sensorineural hearing loss in otitis media. Ann Otol Rhinol Laryngol 81:632–647. https://doi.org/10.1177/000348947208100503CrossRefPubMed

da Costa SS, Paparella MM, Cruz OLM, Rollin GAFS (1995) Chronic otitis media: a clinical-histopathological correlation. Otolaryngol Neck Surg 113:P110–P110. https://doi.org/10.1016/S0194-5998(05)80735-1CrossRef

Livingston G, Sommerlad A, Orgeta V et al (2017) Dementia prevention, intervention, and care. Lancet 390:2673–2734. https://doi.org/10.1016/S0140-6736(17)31363-6CrossRefPubMed

10.

Lin FR, Metter EJ, O’Brien RJ et al (2011) Hearing loss and incident dementia. Arch Neurol 68:214–220. https://doi.org/10.1001/archneurol.2010.362CrossRefPubMedPubMedCentral

11.

Paparella MM (1991) Interactive inner-ear/middle-ear disease, including perilymphatic fistula. Acta Otolaryngol Suppl 485:36–45CrossRefPubMed

12.

Cureoglu S, Schachern PA, Paparella MM, Lindgren BR (2004) Cochlear changes in chronic otitis media. Laryngoscope 114:622–626. https://doi.org/10.1097/00005537-200404000-00006CrossRefPubMed

13.

Goycoolea MV (2001) Clinical aspects of round window membrane permeability under normal and pathological conditions. Acta Otolaryngol (Stockh) 121:437–447CrossRef

14.

Goycoolea MV, Paparella MM, Goldberg B et al (1980) Permeability of the middle ear to staphylococcal pyrogenic exotoxin in otitis media. Int J Pediatr Otorhinolaryngol 1:301–308CrossRefPubMed

15.

Goycoolea MV, Muchow D, Schachern P (1988) Experimental studies on round window structure: function and permeability. Laryngoscope 98:1–20. https://doi.org/10.1288/00005537-198806001-00002CrossRefPubMed

16.

Monsanto RC, Schachern P, Paparella MM et al (2017) Progression of changes in the sensorial elements of the cochlear and peripheral vestibular systems: the otitis media continuum. Hear Res 351:2–10. https://doi.org/10.1016/j.heares.2017.05.003CrossRefPubMedPubMedCentral

17.

da Costa Monsanto R, Erdil M, Pauna HF et al (2016) Pathologic changes of the peripheral vestibular system secondary to chronic otitis media. Otolaryngol Head Neck Surg 155:494–500. https://doi.org/10.1177/0194599816646359CrossRef

18.

Kodama A, Ishii T, Oka Y, Uebo K (1988) Histopathology of the inner ear in chronic otitis media. Equilibr Res 47:94–100CrossRef

19.

Kaya S, Tsuprun V, Hizli Ö et al (2016) Quantitative assessment of cochlear histopathologic findings in patients with suppurative labyrinthitis. JAMA Otolaryngol Head Neck Surg 142:364–369. https://doi.org/10.1001/jamaoto.2015.3803CrossRefPubMed

20.

Schachern PA, Paparella MM, Hybertson R et al (1992) Bacterial tympanogenic labyrinthitis, meningitis, and sensorineural damage. Arch Otolaryngol Head Neck Surg 118:53–57CrossRefPubMed

21.

Paparella MM, Schachern PA, Yoon TH et al (1990) Otopathologic correlates of the continuum of otitis media. Ann Otol Rhinol Laryngol Suppl 148:17–22CrossRefPubMed

22.

Otte J, Schunknecht HF, Kerr AG (1978) Ganglion cell populations in normal and pathological human cochleae. Implications for cochlear implantation. Laryngoscope 88:1231–1246. https://doi.org/10.1288/00005537-197808000-00004CrossRefPubMed

23.

Richter E (1980) Quantitative study of human Scarpa’s ganglion and vestibular sensory epithelia. Acta Otolaryngol (Stockh) 90:199–208CrossRef

24.

Abercrombie M (1946) Estimation of nuclear population from microtome sections. Anat Rec 94:239–247CrossRefPubMed

25.

Casselbrant ML, Furman JM, Rubenstein E, Mandel EM (1995) Effect of otitis media on the vestibular system in children. Ann Otol Rhinol Laryngol 104:620–624. https://doi.org/10.1177/000348949510400806CrossRefPubMed

26.

Cureoglu S, Schachern PA, Rinaldo A et al (2005) Round window membrane and labyrinthine pathological changes: an overview. Acta Otolaryngol (Stockh) 125:9–15. https://doi.org/10.1080/00016480410022534CrossRef

27.

Goycoolea MV, Lundman L (1997) Round window membrane. Structure function and permeability: a review. Microsc Res Tech 36:201–211. https://doi.org/10.1002/(SICI)1097-0029(19970201)36:3%3c201:AID-JEMT8%3e3.0.CO;2-RCrossRefPubMed

28.

MacArthur CJ, Pillers D-AM, Pang J et al (2011) Altered expression of middle and inner ear cytokines in mouse otitis media. Laryngoscope 121:365–371. https://doi.org/10.1002/lary.21349CrossRefPubMedPubMedCentral

29.

MacArthur CJ, Hausman F, Kempton JB et al (2013) Otitis Media Impacts Hundreds of Mouse Middle and Inner Ear Genes. PLoS ONE 8:e75213. https://doi.org/10.1371/journal.pone.0075213CrossRefPubMedPubMedCentral

30.

Paparella MM, Goycoolea MV, Meyerhoff WL, Shea D (1979) Endolymphatic hydrops and otitis media. Laryngoscope 89:43–58PubMed

31.

Makary CA, Shin J, Kujawa SG et al (2011) Age-related primary cochlear neuronal degeneration in human temporal bones. J Assoc Res Otolaryngol 12:711–717. https://doi.org/10.1007/s10162-011-0283-2CrossRefPubMedPubMedCentral

32.

Linthicum FH, Fayad J (2009) Spiral ganglion cell loss is unrelated to segmental cochlear sensory system degeneration in humans. Otol Neurotol 30:418–422CrossRefPubMedPubMedCentral

33.

Kaya S, Tsuprun V, Hızlı Ö et al (2016) Cochlear changes in serous labyrinthitis associated with silent otitis media: a human temporal bone study. Am J Otolaryngol 37:83–88. https://doi.org/10.1016/j.amjoto.2015.10.002CrossRefPubMed

34.

Suzuka Y, Schuknecht HF (1988) Retrograde cochlear neuronal degeneration in human subjects. Acta Otolaryngol Suppl 450:1–20CrossRefPubMed

35.

Zilberstein Y, Liberman MC, Corfas G (2012) Inner hair cells are not required for survival of spiral ganglion neurons in the adult cochlea. J Neurosci 32:405–410. https://doi.org/10.1523/JNEUROSCI.4678-11.2012CrossRefPubMedPubMedCentral

36.

Liberman MC, Liberman LD, Maison SF (2015) Chronic conductive hearing loss leads to cochlear degeneration. PLoS ONE 10:e0142341. https://doi.org/10.1371/journal.pone.0142341CrossRefPubMedPubMedCentral

37.

Okada M, Welling DB, Liberman MC, Maison SF (2019) Chronic conductive hearing loss is associated with speech intelligibility deficits in patients with normal bone conduction thresholds. Ear Hear. https://doi.org/10.1097/AUD.0000000000000787CrossRef

38.

Paparella MM, Shea D, Meyerhoff WL, Goycoolea MV (1980) Silent otitis media. Laryngoscope 90:1089–1098. https://doi.org/10.1288/00005537-198007000-00003CrossRefPubMed

39.

da Monsanto RC, Kasemodel ALP, Tomaz A et al (2018) Current evidence of peripheral vestibular symptoms secondary to otitis media. Ann Med 50:391–401. https://doi.org/10.1080/07853890.2018.1470665CrossRefPubMed

40.

Haapala S, Niemitalo-Haapola E, Raappana A et al (2014) Effects of recurrent acute otitis media on cortical speech-sound processing in 2-year old children. Ear Hear 35:e75–e83. https://doi.org/10.1097/AUD.0000000000000002CrossRefPubMed

41.

Macandie C, O’Reilly BF (1999) Sensorineural hearing loss in chronic otitis media. Clin Otolaryngol 24:220–222. https://doi.org/10.1046/j.1365-2273.1999.00237.xCrossRefPubMed

42.

Liberman MC, Kujawa SG (2017) Cochlear synaptopathy in acquired sensorineural hearing loss: manifestations and mechanisms. Hear Res 349:138–147. https://doi.org/10.1016/j.heares.2017.01.003CrossRefPubMedPubMedCentral

43.

Kujawa SG, Liberman MC (2015) Synaptopathy in the noise-exposed and aging cochlea: primary neural degeneration in acquired sensorineural hearing loss. Hear Res 330:191–199. https://doi.org/10.1016/j.heares.2015.02.009CrossRefPubMedPubMedCentral

44.

Guitton MJ (2012) Tinnitus: pathology of synaptic plasticity at the cellular and system levels. Front Syst Neurosci. https://doi.org/10.3389/fnsys.2012.00012CrossRefPubMedPubMedCentral

45.

Durán Alonso MB, Feijoo-Redondo A, Conde de Felipe M et al (2012) Generation of inner ear sensory cells from bone marrow-derived human mesenchymal stem cells. Regen Med 7:769–783. https://doi.org/10.2217/rme.12.65CrossRefPubMed

Titel: Quantitative assessment of cochlear and vestibular ganglion neurons in temporal bones with chronic otitis media
verfasst von: Rafael da Costa Monsanto
Norma de Oliveira Penido
Mio Uchiyama
Patricia Schachern
Michael M. Paparella
Sebahattin Cureoglu
Publikationsdatum: 01.06.2020
Verlag: Springer Berlin Heidelberg
Erschienen in: European Archives of Oto-Rhino-Laryngology / Ausgabe 2/2021
Print ISSN: 0937-4477
Elektronische ISSN: 1434-4726
DOI: https://doi.org/10.1007/s00405-020-06094-5

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Quantitative assessment of cochlear and vestibular ganglion neurons in temporal bones with chronic otitis media

Abstract

Purpose

Methods

Results

Conclusions and relevance

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Springer Medizin

Abstract

Purpose

Methods

Results

Conclusions and relevance

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