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Erschienen in: Annals of Nuclear Medicine 5/2018

13.04.2018 | Original Article

Quantitative evaluation of the tracer distribution in dopamine transporter SPECT for objective interpretation

verfasst von: Yu Iwabuchi, Tadaki Nakahara, Masashi Kameyama, Yoshitake Yamada, Masahiro Hashimoto, Yuji Ogata, Yohji Matsusaka, Mari Katagiri, Kazunari Itoh, Takashi Osada, Daisuke Ito, Hajime Tabuchi, Masahiro Jinzaki

Erschienen in: Annals of Nuclear Medicine | Ausgabe 5/2018

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Abstract

Purpose

Quantification of the tracer distribution would add objectivity to the visual assessments of dopamine transporter (DAT) single photon emission computed tomography (SPECT) data. Our study aimed to evaluate the diagnostic utility of fractal dimension (FD) as a quantitative indicator of tracer distribution and compared with the conventional quantitative value: specific binding ratio (SBR). We also evaluated the utility of the combined index SBR/FD (SBR divided by FD).

Materials and methods

We conducted both clinical and phantom studies. In the clinical study, 150 patients including 110 patients with Parkinsonian syndrome (PS) and 40 without PS were enrolled. In the phantom study, we used a striatal phantom with the striatum chamber divided into two spaces, representing the caudate nucleus and putamen. The SBR, FD, and SBR/FD were calculated and compared between datasets for evaluating the diagnostic utility. Mann–Whitney test and receiver-operating characteristics (ROC) analysis were used for analysis.

Results

ROC analysis revealed that the FD value had high diagnostic performance [the areas under the curve (AUC) = 0.943] and the combined use of SBR and FD (SBR/FD) delivered better results than the SBR alone (AUC, 0.964 vs 0.899; p < 0.001). The sensitivity, specificity, and accuracy, respectively, were 79.1, 85.0, and 80.7% with SBR, 84.5, 97.5, and 88.0% with FD, and 92.7, 87.5, and 91.3% with SBR/FD.

Conclusion

Our results confirmed that the FD value is a useful diagnostic index, which reflects the tracer distribution in DAT SPECT images. The combined use of SBR and FD was more useful than either used alone.
Literatur
1.
Zurück zum Zitat Vlaar AM, van Kroonenburgh MJ, Kessels AG, Weber WE. Meta-analysis of the literature on diagnostic accuracy of SPECT in parkinsonian syndromes. BMC Neurol. 2007;7:27.CrossRefPubMedPubMedCentral Vlaar AM, van Kroonenburgh MJ, Kessels AG, Weber WE. Meta-analysis of the literature on diagnostic accuracy of SPECT in parkinsonian syndromes. BMC Neurol. 2007;7:27.CrossRefPubMedPubMedCentral
2.
Zurück zum Zitat McKeith I, O’Brien J, Walker Z, Tatsch K, Booij J, Darcourt J, et al. Sensitivity and specificity of dopamine transporter imaging with 123I-FP-CIT SPECT in dementia with Lewy bodies: a phase III, multicentre study. Lancet Neurol. 2007;6:305–13.CrossRefPubMed McKeith I, O’Brien J, Walker Z, Tatsch K, Booij J, Darcourt J, et al. Sensitivity and specificity of dopamine transporter imaging with 123I-FP-CIT SPECT in dementia with Lewy bodies: a phase III, multicentre study. Lancet Neurol. 2007;6:305–13.CrossRefPubMed
3.
Zurück zum Zitat Kwak Y, Müller ML, Bohnen NI, Dayalu P, Seidler RD. Effect of dopaminergic medications on the time course of explicit motor sequence learning in Parkinson’s disease. J Neurophysiol. 2010;103:942–9.CrossRefPubMed Kwak Y, Müller ML, Bohnen NI, Dayalu P, Seidler RD. Effect of dopaminergic medications on the time course of explicit motor sequence learning in Parkinson’s disease. J Neurophysiol. 2010;103:942–9.CrossRefPubMed
4.
Zurück zum Zitat Tondeur MC, Hambye AS, Dethy S, Ham HR. Interobserver reproducibility of the interpretation of I-123 FP-CIT single-photon emission computed tomography. Nucl Med Commun. 2010;31:717–25.CrossRefPubMed Tondeur MC, Hambye AS, Dethy S, Ham HR. Interobserver reproducibility of the interpretation of I-123 FP-CIT single-photon emission computed tomography. Nucl Med Commun. 2010;31:717–25.CrossRefPubMed
5.
Zurück zum Zitat Tossici-Bolt L, Hoffmann SM, Kemp PM, Mehta RL, Fleming JS. Quantification of [123I]FP-CIT SPECT brain images: an accurate technique for measurement of the specific binding ratio. Eur J Nucl Med Mol Imaging. 2006;33:1491–9.CrossRefPubMed Tossici-Bolt L, Hoffmann SM, Kemp PM, Mehta RL, Fleming JS. Quantification of [123I]FP-CIT SPECT brain images: an accurate technique for measurement of the specific binding ratio. Eur J Nucl Med Mol Imaging. 2006;33:1491–9.CrossRefPubMed
6.
Zurück zum Zitat Varrone A, Dickson JC, Tossici-Bolt L, Sera T, Asenbaum S, Booij J, et al. European multicentre database of healthy controls for [123I] FP-CIT SPECT (ENC-DAT): age-related effects, gender differences and evaluation of different methods of analysis. Eur J Nucl Med Mol Imaging. 2013;40:213–27.CrossRefPubMed Varrone A, Dickson JC, Tossici-Bolt L, Sera T, Asenbaum S, Booij J, et al. European multicentre database of healthy controls for [123I] FP-CIT SPECT (ENC-DAT): age-related effects, gender differences and evaluation of different methods of analysis. Eur J Nucl Med Mol Imaging. 2013;40:213–27.CrossRefPubMed
7.
Zurück zum Zitat Nonokuma M, Kuwabara Y, Hida K, Tani T, Takano K, Yoshimitsu K. Optimal ROI setting on the anatomically normalized I-123 FP-CIT images using high-resolution SPECT. Ann Nucl Med. 2016;30:637–44.CrossRefPubMedPubMedCentral Nonokuma M, Kuwabara Y, Hida K, Tani T, Takano K, Yoshimitsu K. Optimal ROI setting on the anatomically normalized I-123 FP-CIT images using high-resolution SPECT. Ann Nucl Med. 2016;30:637–44.CrossRefPubMedPubMedCentral
8.
Zurück zum Zitat Nagao M, Murase K, Yasuhara Y, Ikezoe J. Quantitative analysis of pulmonary emphysema: three-dimensional fractal analysis of single-photon emission computed tomography images obtained with a carbon particle radioaerosol. Am J Roentgenol. 1998;171:1657–63.CrossRef Nagao M, Murase K, Yasuhara Y, Ikezoe J. Quantitative analysis of pulmonary emphysema: three-dimensional fractal analysis of single-photon emission computed tomography images obtained with a carbon particle radioaerosol. Am J Roentgenol. 1998;171:1657–63.CrossRef
9.
Zurück zum Zitat Nagao M, Murase K, Ichiki T, Sakai S, Yasuhara Y, Ikezoe J. Quantitative analysis of technegas SPECT: evaluation of regional severity of emphysema. J Nucl Med. 2000;41:590–5.PubMed Nagao M, Murase K, Ichiki T, Sakai S, Yasuhara Y, Ikezoe J. Quantitative analysis of technegas SPECT: evaluation of regional severity of emphysema. J Nucl Med. 2000;41:590–5.PubMed
10.
Zurück zum Zitat Nagao M, Murase K. Measurement of heterogeneous distribution on Technegas SPECT images by three-dimensional fractal analysis. Ann Nucl Med. 2002;16:369–76.CrossRefPubMed Nagao M, Murase K. Measurement of heterogeneous distribution on Technegas SPECT images by three-dimensional fractal analysis. Ann Nucl Med. 2002;16:369–76.CrossRefPubMed
11.
Zurück zum Zitat Nagao M, Murase K, Kikuchi T, Ikeda M, Nebu A, Fukuhara R, et al. Fractal analysis of cerebral blood flow distribution in Alzheimer’s disease. J Nucl Med. 2001;42:1446–50.PubMed Nagao M, Murase K, Kikuchi T, Ikeda M, Nebu A, Fukuhara R, et al. Fractal analysis of cerebral blood flow distribution in Alzheimer’s disease. J Nucl Med. 2001;42:1446–50.PubMed
12.
Zurück zum Zitat Nagao M, Sugawara Y, Ikeda M, Fukuhara R, Hokoishi K, Murase K, et al. Heterogeneity of cerebral blood flow in frontotemporal lobar degeneration and Alzheimer’s disease. Eur J Nucl Med Mol Imaging. 2004;31:162–8.CrossRefPubMed Nagao M, Sugawara Y, Ikeda M, Fukuhara R, Hokoishi K, Murase K, et al. Heterogeneity of cerebral blood flow in frontotemporal lobar degeneration and Alzheimer’s disease. Eur J Nucl Med Mol Imaging. 2004;31:162–8.CrossRefPubMed
13.
Zurück zum Zitat Nagao M, Sugawara Y, Ikeda M, et al. Heterogeneity of posterior limbic perfusion in very early Alzheimer’s disease. Neurosci Res. 2006;55:285–91.CrossRefPubMed Nagao M, Sugawara Y, Ikeda M, et al. Heterogeneity of posterior limbic perfusion in very early Alzheimer’s disease. Neurosci Res. 2006;55:285–91.CrossRefPubMed
14.
Zurück zum Zitat Södoferlund TA, Dickson JC, Prvulovich E, Ben-Haim S, Kemp P, Booij J, et al. Value of semiquantitative analysis for clinical reporting of 123I-2-β-carbomethoxy-3β-(4-iodopenyl)-N-(3-fluoropropyl)nortropane SPECT studies. J Nucl Med. 2013;54:714–22.CrossRef Södoferlund TA, Dickson JC, Prvulovich E, Ben-Haim S, Kemp P, Booij J, et al. Value of semiquantitative analysis for clinical reporting of 123I-2-β-carbomethoxy-3β-(4-iodopenyl)-N-(3-fluoropropyl)nortropane SPECT studies. J Nucl Med. 2013;54:714–22.CrossRef
15.
Zurück zum Zitat Mäkinen E, Joutsa J, Johansson J, Mäki M, Seppänen M, Kaasinen V. Visual versus automated analysis of [I-123]FP-CIT SPECT scans in parkinsonism. J Neural Transm (Vienna). 2016;123:1309–18.CrossRef Mäkinen E, Joutsa J, Johansson J, Mäki M, Seppänen M, Kaasinen V. Visual versus automated analysis of [I-123]FP-CIT SPECT scans in parkinsonism. J Neural Transm (Vienna). 2016;123:1309–18.CrossRef
17.
Zurück zum Zitat Nicastro N, Garibotto V, Allali G, Assal F, Burkhard PR. Added value of combined semi-quantitative and visual [123I]FP-CIT SPECT analyses for the diagnosis of dementia with Lewy Bodies. Clin Nucl Med. 2017;42(2):e96–e102.CrossRefPubMed Nicastro N, Garibotto V, Allali G, Assal F, Burkhard PR. Added value of combined semi-quantitative and visual [123I]FP-CIT SPECT analyses for the diagnosis of dementia with Lewy Bodies. Clin Nucl Med. 2017;42(2):e96–e102.CrossRefPubMed
19.
Zurück zum Zitat Bland JM, Altman DG. Statistical methods for assessing agreement between two methods of clinical measurement. Lancet. 1986;327:307–10.CrossRef Bland JM, Altman DG. Statistical methods for assessing agreement between two methods of clinical measurement. Lancet. 1986;327:307–10.CrossRef
20.
Zurück zum Zitat DeLong ER, DeLong DM, Clarke-Pearson DL. Comparing the areas under two or more correlated receiver operating characteristic curves: a nonparametric approach. Biometrics. 1988;44:837–45.CrossRefPubMed DeLong ER, DeLong DM, Clarke-Pearson DL. Comparing the areas under two or more correlated receiver operating characteristic curves: a nonparametric approach. Biometrics. 1988;44:837–45.CrossRefPubMed
21.
Zurück zum Zitat Michallek F, Dewey M. Fractal analysis in radiological and nuclear medicine perfusion imaging: a systematic review. Eur Radiol. 2014;24:60–9.CrossRefPubMed Michallek F, Dewey M. Fractal analysis in radiological and nuclear medicine perfusion imaging: a systematic review. Eur Radiol. 2014;24:60–9.CrossRefPubMed
22.
Zurück zum Zitat Kuikka JT, Tiihonen J, Karhu J, Bergström KA, Räsänen P. Fractal analysis of striatal dopamine re-uptake sites. Eur J Nucl Med. 1997;24:1085–90.PubMed Kuikka JT, Tiihonen J, Karhu J, Bergström KA, Räsänen P. Fractal analysis of striatal dopamine re-uptake sites. Eur J Nucl Med. 1997;24:1085–90.PubMed
23.
Zurück zum Zitat Kuikka JT, Yang J, Karhu J, Laitinen T, Tupala E, Hallikainen T, et al. Imaging the structure of the striatum: a fractal approach to SPECT image interpretation. Physiol Meas. 1998;19:367–74.CrossRefPubMed Kuikka JT, Yang J, Karhu J, Laitinen T, Tupala E, Hallikainen T, et al. Imaging the structure of the striatum: a fractal approach to SPECT image interpretation. Physiol Meas. 1998;19:367–74.CrossRefPubMed
24.
Zurück zum Zitat Kuikka JT, Tiihonen J, Bergström KA, Karhu J, Räsänen P, Eronen M. Abnormal structure of human striatal dopamine re-uptake sites in habitually violent alcoholic offenders: a fractal analysis. Neurosci Lett. 1998;253:195–7.CrossRefPubMed Kuikka JT, Tiihonen J, Bergström KA, Karhu J, Räsänen P, Eronen M. Abnormal structure of human striatal dopamine re-uptake sites in habitually violent alcoholic offenders: a fractal analysis. Neurosci Lett. 1998;253:195–7.CrossRefPubMed
25.
Zurück zum Zitat Bolt L, Fleming JS, Kemp PM. The 3D fractal dimension of DaTSCAN Images. Nucl Med Commun. 2006;27:296 (abstract).CrossRef Bolt L, Fleming JS, Kemp PM. The 3D fractal dimension of DaTSCAN Images. Nucl Med Commun. 2006;27:296 (abstract).CrossRef
26.
Zurück zum Zitat Bolt L, Fleming JS, Kemp PM. Quantifying DaTSCAN TM images- a comparison of region-of-interest and fractal analysis. Eur J Nucl Med Mol Imaging. 2006;33:S98 (abstract). Bolt L, Fleming JS, Kemp PM. Quantifying DaTSCAN TM images- a comparison of region-of-interest and fractal analysis. Eur J Nucl Med Mol Imaging. 2006;33:S98 (abstract).
27.
Zurück zum Zitat Yokoyama K, Imabayashi E, Sumida K, Sone D, Kimura Y, Sato N, et al. Computed-tomography-guided anatomic standardization for quantitative assessment of dopamine transporter SPECT. Eur J Nucl Med Mol Imaging. 2017;44:366–72.CrossRefPubMed Yokoyama K, Imabayashi E, Sumida K, Sone D, Kimura Y, Sato N, et al. Computed-tomography-guided anatomic standardization for quantitative assessment of dopamine transporter SPECT. Eur J Nucl Med Mol Imaging. 2017;44:366–72.CrossRefPubMed
29.
Zurück zum Zitat Rizzo G, Copetti M, Arcuti S, Martino D, Fontana A, Logroscino G. Accuracy of clinical diagnosis of Parkinson disease: a systematic review and meta-analysis. Neurology. 2016;86:566 – 76.CrossRefPubMed Rizzo G, Copetti M, Arcuti S, Martino D, Fontana A, Logroscino G. Accuracy of clinical diagnosis of Parkinson disease: a systematic review and meta-analysis. Neurology. 2016;86:566 – 76.CrossRefPubMed
Metadaten
Titel
Quantitative evaluation of the tracer distribution in dopamine transporter SPECT for objective interpretation
verfasst von
Yu Iwabuchi
Tadaki Nakahara
Masashi Kameyama
Yoshitake Yamada
Masahiro Hashimoto
Yuji Ogata
Yohji Matsusaka
Mari Katagiri
Kazunari Itoh
Takashi Osada
Daisuke Ito
Hajime Tabuchi
Masahiro Jinzaki
Publikationsdatum
13.04.2018
Verlag
Springer Japan
Erschienen in
Annals of Nuclear Medicine / Ausgabe 5/2018
Print ISSN: 0914-7187
Elektronische ISSN: 1864-6433
DOI
https://doi.org/10.1007/s12149-018-1256-x

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