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01.06.2007 | Original Article

Quantitative MR characterization of disease activity in the knee in children with juvenile idiopathic arthritis: a longitudinal pilot study

verfasst von: Dagnachew W. Workie, T. Brent Graham, Tal Laor, Akila Rajagopal, Kendall J. O’Brien, Wendy A. Bommer, Judy M. Racadio, Norah J. Shire, Bernard J. Dardzinski

Erschienen in: Pediatric Radiology | Ausgabe 6/2007

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Abstract

Background

The development of a quantifiable and noninvasive method of monitoring disease activity and response to therapy is vital for arthritis management.

Objective

The purpose of this study was to investigate the utility of quantitative dynamic contrast-enhanced MRI (DCE-MRI) based on pharmacokinetic (PK) modeling to evaluate disease activity in the knee and correlate the results with the clinical assessment in children with juvenile idiopathic arthritis (JIA).

Materials and methods

A group of 17 children with JIA underwent longitudinal clinical and laboratory assessment and DCE-MRI of the knee at enrollment, 3 months, and 12 months. A PK model was employed using MRI signal enhancement data to give three parameters, K^trans ^′ (min⁻¹), k_ep (min⁻¹), and V_p ^′ and to calculate synovial volume.

Results

The PK parameters, synovial volumes, and clinical and laboratory assessments in most children were significantly decreased (P < 0.05) at 12 months when compared to the enrollment values. There was excellent correlation between the PK and synovial volume and the clinical and laboratory assessments. Differences in MR and clinical parameter values in individual subjects illustrate persistent synovitis when in clinical remission.

Conclusion

A decrease in PK parameter values obtained from DCE-MRI in children with JIA likely reflects diminution of disease activity. This technique may be used as an objective follow-up measure of therapeutic efficacy in patients with JIA. MR imaging can detect persistent synovitis in patients considered to be in clinical remission.

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Titel: Quantitative MR characterization of disease activity in the knee in children with juvenile idiopathic arthritis: a longitudinal pilot study
verfasst von: Dagnachew W. Workie
T. Brent Graham
Tal Laor
Akila Rajagopal
Kendall J. O’Brien
Wendy A. Bommer
Judy M. Racadio
Norah J. Shire
Bernard J. Dardzinski
Publikationsdatum: 01.06.2007
Verlag: Springer-Verlag
Erschienen in: Pediatric Radiology / Ausgabe 6/2007
Print ISSN: 0301-0449
Elektronische ISSN: 1432-1998
DOI: https://doi.org/10.1007/s00247-007-0449-6

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Quantitative MR characterization of disease activity in the knee in children with juvenile idiopathic arthritis: a longitudinal pilot study

Abstract

Background

Objective

Materials and methods

Results

Conclusion

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Abstract

Background

Objective

Materials and methods

Results

Conclusion

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