Skip to main content
Erschienen in:

01.06.2019 | Case Study

Questioning Fetal Alcohol Syndrome: a Case Report of Multiple Etiological Factors

verfasst von: Jack C. Lennon, Bradford Czochara

Erschienen in: Journal of Pediatric Neuropsychology | Ausgabe 1-2/2019

Einloggen, um Zugang zu erhalten

Abstract

Objective

A 14-year-old, Caucasian, right-handed male presented for neuropsychological evaluation for diagnostic clarification due to attention-deficit/hyperactivity disorder, bipolar I disorder, and oppositional defiant disorder diagnoses and to rule-out fetal alcohol syndrome (FAS) due to aggression, impulsivity, difficulties with authority, and history of legal issues.

Method

Patient was born at 29 weeks gestation without complications. Patient’s adoptive mother reported delays in walking, as well as regression in talking, with suspected prenatal alcohol exposure, neglect, and abuse in first 2 years of life prior to being adopted. Patient is currently in detention setting due to recent homicidal ideation toward family member.

Results

Neuropsychological and psychological tests were administered to assess for FAS and clarify previous diagnoses, for which psychostimulant and antipsychotic medications have proven ineffective. Results suggest minimal intellectual impairment beyond low general processing speed abilities, minor academic achievement concerns in only sentence comprehension, executive dysfunction specifically in inhibition, inefficient learning with early plateau, and externalizing behaviors. Adaptive functioning difficulties are limited to self-direction and safety. No evidence of brain atrophy, delayed physical development, or facial dysmorphia in childhood but significant behavioral concerns suggestive of FASDs.

Conclusion

A wide range of etiological factors with unconfirmed prenatal alcohol exposure, such as neglect, trauma, and poor school attendance, suggests that FAS may be diagnostically restrictive as it pertains to the broad spectrum of prenatal alcohol effects and common comorbidities. FAS criteria may be revisited as it relates to confirmed alcohol exposure when history does not permit.
Literatur
Zurück zum Zitat Achenbach, T. M. (1999). The child behavior checklist and related instruments. In M. E. Maruish (Ed.), The use of psychological testing for treatment planning and outcomes assessment (pp. 429–466). Mahwah: Lawrence Erlbaum Associates Publishers. Achenbach, T. M. (1999). The child behavior checklist and related instruments. In M. E. Maruish (Ed.), The use of psychological testing for treatment planning and outcomes assessment (pp. 429–466). Mahwah: Lawrence Erlbaum Associates Publishers.
Zurück zum Zitat Adleman, N. E., Menon, V., Blasey, C. M., White, C. D., Warsofsky, I. S., Glover, G. H., & Reiss, A. L. (2002). A developmental fMRI study of the Stroop Color-Word task. Neuroimage, 16(1), 61–75.CrossRefPubMed Adleman, N. E., Menon, V., Blasey, C. M., White, C. D., Warsofsky, I. S., Glover, G. H., & Reiss, A. L. (2002). A developmental fMRI study of the Stroop Color-Word task. Neuroimage, 16(1), 61–75.CrossRefPubMed
Zurück zum Zitat American Psychiatric Association. (2013). Diagnostic and Statistical Manual of Mental Disorders (5th ed.). Arlington: American Psychiatric Publishing.CrossRef American Psychiatric Association. (2013). Diagnostic and Statistical Manual of Mental Disorders (5th ed.). Arlington: American Psychiatric Publishing.CrossRef
Zurück zum Zitat Astley, S. J. (2010). Profile of the first 1,400 patients receiving diagnostic evaluations for fetal alcohol spectrum disorders at the Washington State Fetal Alcohol Syndrome Diagnostic & Prevention Network. Journal of Population Therapeutics and Clinical Pharmacology, 17, e-132-ee64. Astley, S. J. (2010). Profile of the first 1,400 patients receiving diagnostic evaluations for fetal alcohol spectrum disorders at the Washington State Fetal Alcohol Syndrome Diagnostic & Prevention Network. Journal of Population Therapeutics and Clinical Pharmacology, 17, e-132-ee64.
Zurück zum Zitat Barkley, R. A. (2010). Why emotional impulsiveness should be a central feature of ADHD. The ADHD Report, 18(4), 1–5.CrossRef Barkley, R. A. (2010). Why emotional impulsiveness should be a central feature of ADHD. The ADHD Report, 18(4), 1–5.CrossRef
Zurück zum Zitat Beck, J. S., Beck, A. T., Jolly, J., & Steer, R. A. (2005). Beck youth inventories for children and adolescents. San Antonio: PsychCorp. Beck, J. S., Beck, A. T., Jolly, J., & Steer, R. A. (2005). Beck youth inventories for children and adolescents. San Antonio: PsychCorp.
Zurück zum Zitat Biederman, J., Spencer, T., Lomedico, A., Day, H., Petty, C. R., & Faraone, S. V. (2012a). Deficient emotional self-regulation and pediatric attention deficit hyperactivity disorder: a family risk analysis. Psychological Medicine, 42(3), 639–646.CrossRefPubMed Biederman, J., Spencer, T., Lomedico, A., Day, H., Petty, C. R., & Faraone, S. V. (2012a). Deficient emotional self-regulation and pediatric attention deficit hyperactivity disorder: a family risk analysis. Psychological Medicine, 42(3), 639–646.CrossRefPubMed
Zurück zum Zitat Biederman, J., Spencer, T. J., Petty, C., Hyder, L. L., O’Connor, K. B., Surman, C. B. H., & Faraone, S. V. (2012b). Longitudinal course of deficient emotional self-regulation CBCL profile in youth with ADHD: a prospective controlled study. Neuropsychiatric Disease and Treatment, 8, 267–276.CrossRefPubMedPubMedCentral Biederman, J., Spencer, T. J., Petty, C., Hyder, L. L., O’Connor, K. B., Surman, C. B. H., & Faraone, S. V. (2012b). Longitudinal course of deficient emotional self-regulation CBCL profile in youth with ADHD: a prospective controlled study. Neuropsychiatric Disease and Treatment, 8, 267–276.CrossRefPubMedPubMedCentral
Zurück zum Zitat Birmaher, B., Brent, D. A., Chiappetta, L., Bridge, J., Monga, S., & Baugher, M. (1999). Psychometric properties of the Screen for Child Anxiety Related Emotional Disorders (SCARED): a replication study. Journal of the American Academy of Child & Adolescent Psychiatry, 38(10), 1230–1236.CrossRef Birmaher, B., Brent, D. A., Chiappetta, L., Bridge, J., Monga, S., & Baugher, M. (1999). Psychometric properties of the Screen for Child Anxiety Related Emotional Disorders (SCARED): a replication study. Journal of the American Academy of Child & Adolescent Psychiatry, 38(10), 1230–1236.CrossRef
Zurück zum Zitat Boone, K. B., Salazar, X., Lu, P., Warner-Chacon, K., & Razani, J. (2010). The Rey-15-item recognition trial: a technique to enhance sensitivity of the Rey 15-item memorization test. Journal of Clinical and Experimental Neuropsychology, 24(5), 561–573.CrossRef Boone, K. B., Salazar, X., Lu, P., Warner-Chacon, K., & Razani, J. (2010). The Rey-15-item recognition trial: a technique to enhance sensitivity of the Rey 15-item memorization test. Journal of Clinical and Experimental Neuropsychology, 24(5), 561–573.CrossRef
Zurück zum Zitat Conners, C. K. (2008). Conners 3rd edition manual. Toronto: Multi-Health Systems. Conners, C. K. (2008). Conners 3rd edition manual. Toronto: Multi-Health Systems.
Zurück zum Zitat Gioia, G., Isquith, P. K., Guy, S. C., & Kenworthy, L. (2000). Behavior Rating Inventory of Executive Function. Child Neuropsychology, 6(3), 235–238.CrossRef Gioia, G., Isquith, P. K., Guy, S. C., & Kenworthy, L. (2000). Behavior Rating Inventory of Executive Function. Child Neuropsychology, 6(3), 235–238.CrossRef
Zurück zum Zitat Green, C. R., Mihic, A. M., Nikkel, S. M., Stade, B. C., Rasmussen, C., Munoz, D. P., et al. (2009). Executive function deficits in children with fetal alcohol spectrum disorders (FASD) measured using the Cambridge Neuropsychological Tests Automated Battery (CANTAB). Journal of Child Psychology & Psychiatry, 50(6), 688–697.CrossRef Green, C. R., Mihic, A. M., Nikkel, S. M., Stade, B. C., Rasmussen, C., Munoz, D. P., et al. (2009). Executive function deficits in children with fetal alcohol spectrum disorders (FASD) measured using the Cambridge Neuropsychological Tests Automated Battery (CANTAB). Journal of Child Psychology & Psychiatry, 50(6), 688–697.CrossRef
Zurück zum Zitat Hosenbocus, S., & Chahal, R. (2012). A review of executive function deficits and pharmacological management in children and adolescents. Journal of the Canadian Academy of Child & Adolescent Psychiatry, 21(3), 223–229. Hosenbocus, S., & Chahal, R. (2012). A review of executive function deficits and pharmacological management in children and adolescents. Journal of the Canadian Academy of Child & Adolescent Psychiatry, 21(3), 223–229.
Zurück zum Zitat Hoyme, H. E., May, P. A., Kalberg, W. O., Kodituwakku, P., Gossage, J. P., Trujillo, P. M., et al. (2005). A practical clinical approach to diagnosis of fetal alcohol spectrum disorders: clarification of the 1996 Institute of Medicine criteria. Pediatrics, 115(1), 39–47.CrossRefPubMed Hoyme, H. E., May, P. A., Kalberg, W. O., Kodituwakku, P., Gossage, J. P., Trujillo, P. M., et al. (2005). A practical clinical approach to diagnosis of fetal alcohol spectrum disorders: clarification of the 1996 Institute of Medicine criteria. Pediatrics, 115(1), 39–47.CrossRefPubMed
Zurück zum Zitat Jarmasz, J. S., Basalah, D. A., Chudley, A. E., & Del Bigio, M. R. (2017). Human brain abnormalities associated with prenatal alcohol exposure and fetal alcohol spectrum disorder. Journal of Neuropathology & Experimental Neurology, 76(9), 813–833. https://doi.org/10.1093/jnen/nlx064.CrossRef Jarmasz, J. S., Basalah, D. A., Chudley, A. E., & Del Bigio, M. R. (2017). Human brain abnormalities associated with prenatal alcohol exposure and fetal alcohol spectrum disorder. Journal of Neuropathology & Experimental Neurology, 76(9), 813–833. https://​doi.​org/​10.​1093/​jnen/​nlx064.CrossRef
Zurück zum Zitat Kaneria, R. M., Patel, N. C., & Keck, P. E. (2005). Bipolar disorder: new strategy for checking serum valproate. Current Psychiatry, 4(12), 31–44. Kaneria, R. M., Patel, N. C., & Keck, P. E. (2005). Bipolar disorder: new strategy for checking serum valproate. Current Psychiatry, 4(12), 31–44.
Zurück zum Zitat Mattson, S. N., Riley, E. P., Gramling, L., Delis, D. C., & Jones, K. L. (1998). Neuropsychological comparison of alcohol-exposed children with or without physical features of fetal alcohol syndrome. Neuropsychology, 12, 146–153.CrossRefPubMed Mattson, S. N., Riley, E. P., Gramling, L., Delis, D. C., & Jones, K. L. (1998). Neuropsychological comparison of alcohol-exposed children with or without physical features of fetal alcohol syndrome. Neuropsychology, 12, 146–153.CrossRefPubMed
Zurück zum Zitat Murphy, A., Steele, H., Steele, M., Allman, B., Kastner, T., & Dube, S. R. (2016). The Clinical Adverse Childhood Experiences (ACEs) Questionnaire: implications for trauma-informed healthcare. In R. D. Briggs (Ed.), Integrated early childhood behavioral health in primary care: a guide to implementation and evaluation (pp. 7–16). Cham: Springer International Publishing. https://doi.org/10.1007/978-3-319-31815-8_2.CrossRef Murphy, A., Steele, H., Steele, M., Allman, B., Kastner, T., & Dube, S. R. (2016). The Clinical Adverse Childhood Experiences (ACEs) Questionnaire: implications for trauma-informed healthcare. In R. D. Briggs (Ed.), Integrated early childhood behavioral health in primary care: a guide to implementation and evaluation (pp. 7–16). Cham: Springer International Publishing. https://​doi.​org/​10.​1007/​978-3-319-31815-8_​2.CrossRef
Zurück zum Zitat Nash, K., Rovet, J., Greenbaum, R., Fantus, E., Nulman, I., & Koren, G. (2006). Identifying the behavioral phenotype in fetal alcohol spectrum disorder: sensitivity, specificity and screening potential. Archives of Women's Mental Health, 9(4), 181–186.CrossRefPubMed Nash, K., Rovet, J., Greenbaum, R., Fantus, E., Nulman, I., & Koren, G. (2006). Identifying the behavioral phenotype in fetal alcohol spectrum disorder: sensitivity, specificity and screening potential. Archives of Women's Mental Health, 9(4), 181–186.CrossRefPubMed
Zurück zum Zitat Nitch, S., Boone, K. B., Wen, J., Arnold, G., & Alfano, K. (2005). The utility of the Rey Word Recognition Test in the detection of suspect effort. The Clinical Neuropsychologist, 20(4), 873–887.CrossRef Nitch, S., Boone, K. B., Wen, J., Arnold, G., & Alfano, K. (2005). The utility of the Rey Word Recognition Test in the detection of suspect effort. The Clinical Neuropsychologist, 20(4), 873–887.CrossRef
Zurück zum Zitat Peadon, E., & Elliott, E. J. (2010). Distinguishing between attention-deficit hyperactivity and fetal alcohol spectrum disorders in children: clinical guidelines. Neuropsychiatric Disease and Treatment, 6, 509–515.CrossRefPubMedPubMedCentral Peadon, E., & Elliott, E. J. (2010). Distinguishing between attention-deficit hyperactivity and fetal alcohol spectrum disorders in children: clinical guidelines. Neuropsychiatric Disease and Treatment, 6, 509–515.CrossRefPubMedPubMedCentral
Zurück zum Zitat Rasmussen, C., Andrew, G., Zwaigenbaum, L., & Tough, S. (2008). Neurobehavioral outcomes of children with fetal alcohol spectrum disorders: a Canadian perspective. Paediatrics & Child Health, 13(3), 185–191. Rasmussen, C., Andrew, G., Zwaigenbaum, L., & Tough, S. (2008). Neurobehavioral outcomes of children with fetal alcohol spectrum disorders: a Canadian perspective. Paediatrics & Child Health, 13(3), 185–191.
Zurück zum Zitat Rasmussen, C., Benz, J., Pei, J., Andrew, G., Schuller, G., Abele-Webster, L., et al. (2010). The impact of an ADHD co-morbidity on the diagnosis of FASD. The Canadian Journal of Clinical Pharmacology, 17(1), e165–e176.PubMed Rasmussen, C., Benz, J., Pei, J., Andrew, G., Schuller, G., Abele-Webster, L., et al. (2010). The impact of an ADHD co-morbidity on the diagnosis of FASD. The Canadian Journal of Clinical Pharmacology, 17(1), e165–e176.PubMed
Zurück zum Zitat Reynolds, C. R., & Kamphaus, R. W. (2015). Behavior Assessment System for Children, Third Edition (BASC-3). Bloomington: Pearson. Reynolds, C. R., & Kamphaus, R. W. (2015). Behavior Assessment System for Children, Third Edition (BASC-3). Bloomington: Pearson.
Zurück zum Zitat Riley, E. P., Mattson, S. N., Sowell, E. R., Jemigan, T. L., Sobel, D. F., & Jones, K. L. (1995). Abnormalities of the corpus callosum in children prenatally exposed to alcohol. Alcoholism, Clinical and Experimental Research, 19(5), 1198–1202.CrossRefPubMed Riley, E. P., Mattson, S. N., Sowell, E. R., Jemigan, T. L., Sobel, D. F., & Jones, K. L. (1995). Abnormalities of the corpus callosum in children prenatally exposed to alcohol. Alcoholism, Clinical and Experimental Research, 19(5), 1198–1202.CrossRefPubMed
Zurück zum Zitat Saunders, E. H., Scott, L. J., McInnis, M. G., & Burmeister, M. (2008). Familiality and diagnostic patterns of subphenotypes in the National Institutes of Mental Health bipolar sample. American Journal of Medical Genetics Part B: Neuropsychiatric Genetics, 147B(1), 18–26.CrossRef Saunders, E. H., Scott, L. J., McInnis, M. G., & Burmeister, M. (2008). Familiality and diagnostic patterns of subphenotypes in the National Institutes of Mental Health bipolar sample. American Journal of Medical Genetics Part B: Neuropsychiatric Genetics, 147B(1), 18–26.CrossRef
Zurück zum Zitat Stratton, K.R., Howe, C.J., Battaglia, F.C. (1996). Fetal alcohol syndrome - diagnosis, epidemiology, prevention, and treatment. Washington, DC: National Academy Press. Stratton, K.R., Howe, C.J., Battaglia, F.C. (1996). Fetal alcohol syndrome - diagnosis, epidemiology, prevention, and treatment. Washington, DC: National Academy Press.
Zurück zum Zitat Stroop, J. R. (1935). Studies of interference in serial verbal reactions. Journal of Experimental Psychology, 18, 643–662.CrossRef Stroop, J. R. (1935). Studies of interference in serial verbal reactions. Journal of Experimental Psychology, 18, 643–662.CrossRef
Zurück zum Zitat Sulik, K. K., Johnston, M. C., & Webb, M. A. (1981). Fetal alcohol syndrome: embryogenesis in a mouse model. Science, 214, 936–938.CrossRefPubMed Sulik, K. K., Johnston, M. C., & Webb, M. A. (1981). Fetal alcohol syndrome: embryogenesis in a mouse model. Science, 214, 936–938.CrossRefPubMed
Zurück zum Zitat Surman, C. B. H., Biederman, J., Spencer, T., Miller, C. A., Petty, C. R., & Faraone, S. V. (2015). Neuropsychological deficits are not predictive of deficient emotional self-regulation in adults with ADHD. Journal of Attention Disorders, 19(12), 1046–1053.CrossRefPubMed Surman, C. B. H., Biederman, J., Spencer, T., Miller, C. A., Petty, C. R., & Faraone, S. V. (2015). Neuropsychological deficits are not predictive of deficient emotional self-regulation in adults with ADHD. Journal of Attention Disorders, 19(12), 1046–1053.CrossRefPubMed
Zurück zum Zitat Vaurio, L., Riley, E. P., & Mattson, S. N. (2008). Differences in executive functioning in children with heavy prenatal alcohol exposure or attention-deficit/hyperactivity disorder. Journal of the International Neuropsychological Society, 14, 119–129.CrossRefPubMedPubMedCentral Vaurio, L., Riley, E. P., & Mattson, S. N. (2008). Differences in executive functioning in children with heavy prenatal alcohol exposure or attention-deficit/hyperactivity disorder. Journal of the International Neuropsychological Society, 14, 119–129.CrossRefPubMedPubMedCentral
Zurück zum Zitat Wechsler, D. (2014). Wechsler Intelligence Scale for Children-Fifth Edition. Bloomington: Pearson. Wechsler, D. (2014). Wechsler Intelligence Scale for Children-Fifth Edition. Bloomington: Pearson.
Zurück zum Zitat Wilkinson, G. S., & Robertson, G. J. (2006). Wide Range Achievement Test 4 professional manual. Lutz: Psychological Assessment Resources. Wilkinson, G. S., & Robertson, G. J. (2006). Wide Range Achievement Test 4 professional manual. Lutz: Psychological Assessment Resources.
Zurück zum Zitat Willoughby, K. A., Sheard, E. D., Nash, K., & Rovet, J. (2008). Effects of prenatal alcohol exposure on hippocampal volume, verbal learning, and verbal and spatial recall in late childhood. Journal of the International Neuropsychological Society, 14(6), 1022–1033.CrossRefPubMed Willoughby, K. A., Sheard, E. D., Nash, K., & Rovet, J. (2008). Effects of prenatal alcohol exposure on hippocampal volume, verbal learning, and verbal and spatial recall in late childhood. Journal of the International Neuropsychological Society, 14(6), 1022–1033.CrossRefPubMed
Metadaten
Titel
Questioning Fetal Alcohol Syndrome: a Case Report of Multiple Etiological Factors
verfasst von
Jack C. Lennon
Bradford Czochara
Publikationsdatum
01.06.2019
Verlag
Springer International Publishing
Erschienen in
Journal of Pediatric Neuropsychology / Ausgabe 1-2/2019
Print ISSN: 2199-2681
Elektronische ISSN: 2199-2673
DOI
https://doi.org/10.1007/s40817-019-00065-3

Kompaktes Leitlinien-Wissen Neurologie (Link öffnet in neuem Fenster)

Mit medbee Pocketcards schnell und sicher entscheiden.
Leitlinien-Wissen kostenlos und immer griffbereit auf ihrem Desktop, Handy oder Tablet.

Neu im Fachgebiet Neurologie

Stumme Schlaganfälle − ein häufiger Nebenbefund im Kopf-CT?

In 4% der in der Notfallambulanz initiierten zerebralen Bildgebung sind „alte“ Schlaganfälle zu erkennen. Gar nicht so selten handelt es sich laut einer aktuellen Studie dabei um unbemerkte Insulte. Bietet sich hier womöglich die Chance auf ein effektives opportunistisches Screening?

Die elektronische Patientenakte kommt: Das sollten Sie jetzt wissen

Am 15. Januar geht die „ePA für alle“ zunächst in den Modellregionen an den Start. Doch schon bald soll sie in allen Praxen zum Einsatz kommen. Was ist jetzt zu tun? Was müssen Sie wissen? Wir geben in einem FAQ Antworten auf 21 Fragen.

CGRP-Antikörper auch bei älteren Migränekranken sicher

Beginnen ältere Migränekranke eine Prophylaxe mit CGRP-Antikörpern, kommt es anschließend nicht häufiger zu kardiovaskulären Problemen als unter einer Prophylaxe mit Botulinumtoxin. Darauf deutet eine US-Analyse von Medicare-Versicherten.

Frühwarnzeichen für multiple Sklerose bei Kindern und Jugendlichen

Ein Forschungsteam aus Deutschland und Kanada hat eine Reihe metabolischer, okulärer, muskuloskelettaler, gastrointestinaler und kardiovaskulärer Symptome identifiziert, die bei Kindern und Jugendlichen der Diagnose einer multiplen Sklerose (MS) vorausgehen können.

Update Neurologie

Bestellen Sie unseren Fach-Newsletter und bleiben Sie gut informiert.