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01.12.2011 | Case report | Ausgabe 1/2011 Open Access

Journal of Medical Case Reports 1/2011

Quinupristin/dalfopristin in Staphylococcus aureus endophthalmitis: a case report

Journal of Medical Case Reports > Ausgabe 1/2011
Sergio E Hernandez-Da Mota
Wichtige Hinweise

Electronic supplementary material

The online version of this article (doi:10.​1186/​1752-1947-5-130) contains supplementary material, which is available to authorized users.

Competing interests

The author declares that they have no competing interests.

Authors' contributions

The author was in charge of the patient's treatment and follow-up, as well as the echography study. He was also responsible for the manuscript drafting and revision.



The intravitreal injection of antibiotics remains the mainstay of therapy for postoperative endophthalmitis. Bacterial resistance, however, is still a pitfall in achieving an adequate response to treatment. Quinupristin/dalfopristin might be a feasible therapeutic option in these cases.

Case presentation

A 55-year-old Hispanic man had endophthalmitis secondary to Staphylococcus aureus in his right eye and was treated with intravitreal 0.4 mg/0.1 ml quinupristin/dalfopristin injection. Inflammation and pain remission were observed at four days after injection. The final best-corrected visual acuity was 20/40.


Although vancomycin remains the first-line intravitreal antibiotic therapy against infectious endophthalmitis caused by Gram-positive bacteria, quinupristin/dalfopristin exhibits similar efficacy and is theoretically more active against vancomycin-resistant strains, with no apparent retinal toxicity.

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