Introduction
Case report
Discussion
Authors | Type of study | N pts | Age of MA onset range/mean | Migraine/headache Features | Frequency | Duration (h) | Cerebellar sign and symptoms | Other clinical features | Age at onset of cerebellar signs | Cerebral MRI/CT |
---|---|---|---|---|---|---|---|---|---|---|
Battistini et al. [7] | Family | 3/11 | 17–40 years | Typical paroxysmal manifestations of HM. 1 pt asymptomatic for HM | 12–24/year | Minutes–72 h | Permanent cerebellar ataxia | 1 proband with episodes of severe migraine associated with confusion and fever | 60 years | Cerebellar atrophy |
Ducros et al. [3] | Population | 16/117 | 11.7 ± 8.1 mean ± DS | 13/16 HM | N.r. | 0.5–125 h | Permanent cerebellar ataxia. In 13/16 pts | Ataxia without nystagmus | N.r. | N.r. |
Terwindt et al. [8] | Population | 1/27 | 13 years | Migraine attacks with aphasia, hemiparesis, and confusion | N.r. | <1 h | Permanent cerebellar ataxia | – | N.r. | Normal |
Alonso et al. [5] | Family | 17 pts from a family | 3–23 years | 9/17 pts with HM | 2/year | 24 h | No | Episodes of altered consciousness, focal neurological deficits precipitated or not by minor head trauma | 16–50 years | Cerebellar atrophy |
Thomsen et al. [6] | Population based | 11/291 | 5–44 years | HM in 8 pts with nausea, vomiting, photofobia and phonofobia. Headache always accompanying attacks | 1–8/year | 1–48 h | Permanent cerebellar ataxia in 13 pts | Three non affected relatives carried the mutation | N.r. | Cerebellar atrophy in 1 pt |
Our case | Case report | 1 | 13 years | HM with transient left hemiparesis, vision loss and paresthesia in right limbs | 6/year | <1 | Permanent cerebellar ataxia | Decreased level of consciousness, dysarthria, vision loss and sensory deficit alternating in limb side | 50 years | Cerebellar atrophy |