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Breast Cancer Research

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01.12.2009 | Short communication

Radiation impact in breast cancer

verfasst von: Joseph Ragaz

Erschienen in: Breast Cancer Research | Sonderheft 3/2009

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Excerpt

Four questions were considered pivotal by the organizers of the Controversies in Breast Cancer 2009 meeting in Edinburgh, September 2009 with regards to the radiation (RT) effect in the adjuvant setting of early breast cancer: What are the data indicating that local radiotherapy is associated with long-term survival benefit? What must be irradiated to obtain a long-term effect? What is the mechanism of action whereby local RT can influence long-term outcome? Is the RT effect applicable to different subsets? Answers to these questions constitute the present contribution. …

Ragaz J, Jackson SM, Le N, Plenderleith IH, Spinelli JJ, Basco VE, Wilson KS, Knowling MA, Coppin CM, Paradis M, Coldman AJ, Olivotto IA: Adjuvant radiotherapy and chemotherapy in node-positive premenopausal women with breast cancer [see comments]. N Engl J Med. 1997, 337: 956-962. 10.1056/NEJM199710023371402.CrossRefPubMed

Overgaard M, Hansen PS, Overgaard J, Rose C, Andersson M, Bach F, Kjaer M, Gadeberg CC, Mouridsen HT, Jensen MB, Zedeler K: Postoperative radiotherapy in high-risk pre-menopausal women with breast cancer who receive adjuvant chemotherapy. Danish Breast Cancer Cooperative Group 82b Trial. N Engl J Med. 1997, 337: 949-955. 10.1056/NEJM199710023371401.CrossRefPubMed

Bonadonna G, Brusamolino E, Valagussa P, Rossi A, Brugnatelli L, Brambilla C, De Lena M, Tancini G, Bajetta E, Musumeci R, Veronesi U: Combination chemotherapy as an adjuvant treatment in operable breast cancer. N Engl J Med. 1976, 294: 405-410. 10.1056/NEJM197602192940801.CrossRefPubMed

Fisher B, Carbone P, Economou SG, Frelick R, Glass A, Lerner H, Redmond C, Zelen M, Band P, Katrych DL, Wolmark N, Fisher ER: L-Phenylalanine mustard (L-PAM) in the management of primary breast cancer: a report of early findings. N Engl J Med. 1975, 292: 117-122. 10.1056/NEJM197501162920301.CrossRefPubMed

Cuzick J: Overview of adjuvant radiotherapy for breast cancer. Recent Results Cancer Res. 1988, 111: 105-107. 10.1007/978-3-642-83419-6_14.CrossRefPubMed

Early Breast Cancer Trialists Collaborative Group: Effects of radiotherapy and of differences in the extent of surgery for early breast cancer on local recurrence and 15-year survival: an overview of the randomised trials. The Lancet. 2005, 366: 2087-2106.CrossRef

Law LW: Origin of the resistance of leukaemic cells to folic acid anatagonists. Nature. 1952, 169: 628-629. 10.1038/169628a0.CrossRefPubMed

Goldie JH, Coldman AJ: A mathematic model for relating the drug sensitivity of tumors to their spontaneous mutation rate. Cancer Treat Rep. 1979, 63: 1727-1733.PubMed

Skipper HE: Implications of biochemical, cytokinetic, pharmacologic, and toxicologic relationship in the design of optimal therapeutic schedules. Cancer Chemother Rep. 1970, 54: 431-450.PubMed

10.

Skipper HE: Tumor differences, drug differences and effects on therapeutic outcome. Prog Clin Biol Res. 1990, 354A: 81-99.PubMed

11.

Steel G: Growth Kinetics of Tumors. 1977, Oxford: Clarendon Press, 57-62.

12.

Ragaz J, Olivotto IA, Spinelli JJ, Phillips N, Jackson SM, Wilson KS, Knowling MA, Coppin CM, Weir L, Gelmon K, Le N, Durand R, Coldman AJ, Manji M: Locoregional radiation therapy in patients with high-risk breast cancer receiving adjuvant chemotherapy: 20-year results of the British Columbia randomized trial. J Natl Cancer Inst. 2005, 97: 116-126. 10.1093/jnci/djh297.CrossRefPubMed

13.

Nielsen HM, Overgaard M, Grau C, Jensen AR, Overgaard J: Study of failure pattern among high-risk breast cancer patients with or without postmastectomy radiotherapy in addition to adjuvant systemic therapy: long-term results from the Danish Breast Cancer Cooperative Group DBCG 82 b and c randomized studies. J Clin Oncol. 2006, 24: 2268-2275. 10.1200/JCO.2005.02.8738.CrossRefPubMed

14.

Anonymous: Favourable and unfavourable effects on long-term survival of radiotherapy for early breast cancer: an overview of the randomised trials. Early Breast Cancer Trialists' Collaborative Group. Lancet. 2000, 355: 1757-1770. 10.1016/S0140-6736(00)02263-7.CrossRef

15.

Marks LB, Zeng J, Prosnitz LR: One to three versus four or more positive nodes and postmastectomy radiotherapy: time to end the debate. J Clin Oncol. 2008, 26: 2075-2077. 10.1200/JCO.2007.15.5200.CrossRefPubMed

16.

Cheng SH, Horng CF, West M, Huang E, Pittman J, Tsou MH, Dressman H, Chen CM, Tsai SY, Jian JJ, Liu MC, Nevins JR, Huang AT: Genomic prediction of locoregional recurrence after mastectomy in breast cancer. J Clin Oncol. 2006, 24: 4594-4602. 10.1200/JCO.2005.02.5676.CrossRefPubMed

17.

Truong PT, Woodward WA, Thames HD, Ragaz J, Olivotto IA, Buchholz TA: The ratio of positive to excised nodes identifies high-risk subsets and reduces inter-institutional differences in locoregional recurrence risk estimates in breast cancer patients with 1-3 positive nodes: an analysis of prospective data from British Columbia and the M. D. Anderson Cancer Center. Int J Radiat Oncol Biol Phys. 2007, 68: 59-65. 10.1016/j.ijrobp.2006.12.017.CrossRefPubMed

18.

Ragaz J, Worth A, Le N, Hayes M: Extracapsular spread: adverse prognostic factor in chemotherapy-treated Stage I-II breast cancer, predictive for survival impact of locoregional radiotherapy. Observation from the British Columbia Randomized Trial. Breast Cancer Res Treat. 1999, A411: 57-58.

19.

Paik S, Shak S, Tang G, Kim C, Baker J, Cronin M, Baehner FL, Walker MG, Watson D, Park T, Hiller W, Fisher ER, Wickerham DL, Bryant J, Wolmark N: A multigene assay to predict recurrence of tamoxifen-treated, node-negative breast cancer. N Engl J Med. 2004, 351: 2817-2826. 10.1056/NEJMoa041588.CrossRefPubMed

20.

Arriagada R, Rutqvist LE, Mattsson A, Kramar A, Rotstein S: Adequate locoregional treatment for early breast cancer may prevent secondary dissemination [see comments]. J Clin Oncol. 1995, 13: 2869-2878.PubMed

Titel: Radiation impact in breast cancer
verfasst von: Joseph Ragaz
Publikationsdatum: 01.12.2009
Verlag: BioMed Central
Erschienen in: Breast Cancer Research / Ausgabe Sonderheft 3/2009
Elektronische ISSN: 1465-542X
DOI: https://doi.org/10.1186/bcr2433

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