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09.11.2018 | Gastrointestinal

Radiomics model of contrast-enhanced computed tomography for predicting the recurrence of acute pancreatitis

Zeitschrift:
European Radiology
Autoren:
Yong Chen, Tian-wu Chen, Chang-qiang Wu, Qiao Lin, Ran Hu, Chao-lian Xie, Hou-dong Zuo, Jia-long Wu, Qi-wen Mu, Quan-shui Fu, Guo-qing Yang, Xiao Ming Zhang
Wichtige Hinweise

Electronic supplementary material

The online version of this article (https://​doi.​org/​10.​1007/​s00330-018-5824-1) contains supplementary material, which is available to authorized users.
Yong Chen and Tian-wu Chen contributed equally to this work.

Abstract

Objectives

To predict the recurrence of acute pancreatitis (AP) by constructing a radiomics model of contrast-enhanced computed tomography (CECT) at AP first attack.

Methods

We retrospectively enrolled 389 first-attack AP patients (271 in the primary cohort and 118 in the validation cohort) from three tertiary referral centers; 126 and 55 patients endured recurrent attacks in each cohort. Four hundred twelve radiomics features were extracted from arterial and venous phase CECT images, and clinical characteristics were gathered to develop a clinical model. An optimal radiomics signature was chosen using a multivariable logistic regression or support vector machine. The radiomics model was developed and validated by incorporating the optimal radiomics signature and clinical characteristics. The performance of the radiomics model was assessed based on its calibration and classification metrics.

Results

The optimal radiomics signature was developed based on a multivariable logistic regression with 10 radiomics features. The classification accuracy of the radiomics model well predicted the recurrence of AP for both the primary and validation cohorts (87.1% and 89.0%, respectively). The area under the receiver operating characteristic curve (AUC) of the radiomics model was significantly better than that of the clinical model for both the primary (0.941 vs. 0.712, p = 0.000) and validation (0.929 vs. 0.671, p = 0.000) cohorts. Good calibration was observed for all the models (p > 0.05).

Conclusions

The radiomics model based on CECT performed well in predicting AP recurrence. As a quantitative method, radiomics exhibits promising performance in terms of alerting recurrent patients to potential precautions.

Key Points

The incidence of recurrence after an initial episode of acute pancreatitis is high, and quantitative methods for predicting recurrence are lacking.
The radiomics model based on contrast-enhanced computed tomography performed well in predicting the recurrence of acute pancreatitis.
As a quantitative method, radiomics exhibits promising performance in terms of alerting recurrent patients to the potential need to take precautions.

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