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Erschienen in: European Radiology 2/2019

02.07.2018 | Chest

Radiomics signature: a biomarker for the preoperative discrimination of lung invasive adenocarcinoma manifesting as a ground-glass nodule

verfasst von: Li Fan, MengJie Fang, ZhaoBin Li, WenTing Tu, ShengPing Wang, WuFei Chen, Jie Tian, Di Dong, ShiYuan Liu

Erschienen in: European Radiology | Ausgabe 2/2019

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Abstract

Objectives

To identify the radiomics signature allowing preoperative discrimination of lung invasive adenocarcinomas from non-invasive lesions manifesting as ground-glass nodules.

Methods

This retrospective primary cohort study included 160 pathologically confirmed lung adenocarcinomas. Radiomics features were extracted from preoperative non-contrast CT images to build a radiomics signature. The predictive performance and calibration of the radiomics signature were evaluated using intra-cross (n=76), external non-contrast-enhanced CT (n=75) and contrast-enhanced CT (n=84) validation cohorts. The performance of radiomics signature and CT morphological and quantitative indices were compared.

Results

355 three-dimensional radiomics features were extracted, and two features were identified as the best discriminators to build a radiomics signature. The radiomics signature showed a good ability to discriminate between invasive adenocarcinomas and non-invasive lesions with an accuracy of 86.3%, 90.8%, 84.0% and 88.1%, respectively, in the primary and validation cohorts. It remained an independent predictor after adjusting for traditional preoperative factors (odds ratio 1.87, p < 0.001) and demonstrated good calibration in all cohorts. It was a better independent predictor than CT morphology or mean CT value.

Conclusions

The radiomics signature showed good predictive performance in discriminating between invasive adenocarcinomas and non-invasive lesions. Being a non-invasive biomarker, it could assist in determining therapeutic strategies for lung adenocarcinoma.

Key Points

• The radiomics signature was a non-invasive biomarker of lung invasive adenocarcinoma.
• The radiomics signature outweighed CT morphological and quantitative indices.
• A three-centre study showed that radiomics signature had good predictive performance.
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Metadaten
Titel
Radiomics signature: a biomarker for the preoperative discrimination of lung invasive adenocarcinoma manifesting as a ground-glass nodule
verfasst von
Li Fan
MengJie Fang
ZhaoBin Li
WenTing Tu
ShengPing Wang
WuFei Chen
Jie Tian
Di Dong
ShiYuan Liu
Publikationsdatum
02.07.2018
Verlag
Springer Berlin Heidelberg
Erschienen in
European Radiology / Ausgabe 2/2019
Print ISSN: 0938-7994
Elektronische ISSN: 1432-1084
DOI
https://doi.org/10.1007/s00330-018-5530-z

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