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Erschienen in: Acta Neurochirurgica 9/2016

19.07.2016 | Case Report - Brain Tumors

Radiosurgery for infundibulum adenoma: stalk dose implications

verfasst von: Jennifer D. Sokolowski, Or Cohen-Inbar, Jason P. Sheehan

Erschienen in: Acta Neurochirurgica | Ausgabe 9/2016

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Abstract

Treating pituitary adenomas in the infundibulum with stereotactic radiosurgery (SRS), achieving tumor volume control while preserving pituitary endocrine function and visual function, is challenging. We present a case of a recurrent remnant infundibular lesion treated with Gamma Knife surgery (GKS). The mass was treated with microsurgical resection twice, and the residual stalk lesion was treated with single-session SRS employing a margin dose of 15 Gy to the infundibulum. Five years after GKS, tumor regression persists without visual dysfunction or hypopituitarism. Radiosurgical doses of 30 Gy to the pituitary stalk may be tolerated by patients while maintaining endocrine function.
Literatur
1.
Zurück zum Zitat Feigl GC, Bonelli CM, Berghold A, Mokry M (2002) Effects of Gamma Knife radiosurgery of pituitary adenomas on pituitary function. J Neurosurg 97(5 Suppl):415–421PubMed Feigl GC, Bonelli CM, Berghold A, Mokry M (2002) Effects of Gamma Knife radiosurgery of pituitary adenomas on pituitary function. J Neurosurg 97(5 Suppl):415–421PubMed
2.
Zurück zum Zitat Feigl GC, Pistracher K, Berghold A, Mokry M (2010) Pituitary insufficiency as a side effect after radiosurgery for pituitary adenomas: the role of the hypothalamus. J Neurosurg 113(Suppl):153–159PubMed Feigl GC, Pistracher K, Berghold A, Mokry M (2010) Pituitary insufficiency as a side effect after radiosurgery for pituitary adenomas: the role of the hypothalamus. J Neurosurg 113(Suppl):153–159PubMed
3.
Zurück zum Zitat Jagannathan J, Yen CP, Pouratian N, Laws ER, Sheehan JP (2009) Stereotactic radiosurgery for pituitary adenomas: a comprehensive review of indications, techniques and long-term results using the Gamma Knife. J Neurooncol 92(3):345–356CrossRefPubMed Jagannathan J, Yen CP, Pouratian N, Laws ER, Sheehan JP (2009) Stereotactic radiosurgery for pituitary adenomas: a comprehensive review of indications, techniques and long-term results using the Gamma Knife. J Neurooncol 92(3):345–356CrossRefPubMed
4.
Zurück zum Zitat Marek J, Jezkova J, Hana V, Krsek M, Bandurova L, Pecen L, Vladyka V, Liscak R (2011) Is it possible to avoid hypopituitarism after irradiation of pituitary adenomas by the Leksell Gamma Knife? Eur J Endocrinol 164(2):169–178CrossRefPubMed Marek J, Jezkova J, Hana V, Krsek M, Bandurova L, Pecen L, Vladyka V, Liscak R (2011) Is it possible to avoid hypopituitarism after irradiation of pituitary adenomas by the Leksell Gamma Knife? Eur J Endocrinol 164(2):169–178CrossRefPubMed
5.
Zurück zum Zitat Pamir MN, Kilic T, Belirgen M, Abacioglu U, Karabekiroglu N (2007) Pituitary ade1nomas treated with Gamma Knife radiosurgery: volumetric analysis of 100 cases with minimum 3 year follow-up. Neurosurgery 61(2):270–280CrossRefPubMed Pamir MN, Kilic T, Belirgen M, Abacioglu U, Karabekiroglu N (2007) Pituitary ade1nomas treated with Gamma Knife radiosurgery: volumetric analysis of 100 cases with minimum 3 year follow-up. Neurosurgery 61(2):270–280CrossRefPubMed
6.
Zurück zum Zitat Picozzi P, Losa M, Mortini P, Valle MA, Franzin A, Attuati L, Ferrari da Passano C, Giovanelli M (2005) Radiosurgery and the prevention of regrowth of incompletely removed nonfunctioning pituitary adenomas. J Neurosurg 102(Suppl):71–74CrossRefPubMed Picozzi P, Losa M, Mortini P, Valle MA, Franzin A, Attuati L, Ferrari da Passano C, Giovanelli M (2005) Radiosurgery and the prevention of regrowth of incompletely removed nonfunctioning pituitary adenomas. J Neurosurg 102(Suppl):71–74CrossRefPubMed
7.
Zurück zum Zitat Sheehan JP, Starke RM, Mathieu D, Young B, Sneed PK, Chiang VL, Lee JY, Kano H, Park KJ, Niranjan A, Kondziolka D, Barnett GH, Rush S, Golfinos JG, Lunsford LD (2013) Gamma Knife radiosurgery for the management of nonfunctioning pituitary adenomas: a multicenter study. J Neurosurg 119(2):446–456CrossRefPubMed Sheehan JP, Starke RM, Mathieu D, Young B, Sneed PK, Chiang VL, Lee JY, Kano H, Park KJ, Niranjan A, Kondziolka D, Barnett GH, Rush S, Golfinos JG, Lunsford LD (2013) Gamma Knife radiosurgery for the management of nonfunctioning pituitary adenomas: a multicenter study. J Neurosurg 119(2):446–456CrossRefPubMed
8.
Zurück zum Zitat Sicignano G, Losa M, del Vecchio A, Cattaneo GM, Picozzi P, Bolognesi A, Mortini P, Calandrino R (2012) Dosimetric factors associated with pituitary function after Gamma Knife surgery (GKS) of pituitary adenomas. Radiother Oncol 104(1):119–124CrossRefPubMed Sicignano G, Losa M, del Vecchio A, Cattaneo GM, Picozzi P, Bolognesi A, Mortini P, Calandrino R (2012) Dosimetric factors associated with pituitary function after Gamma Knife surgery (GKS) of pituitary adenomas. Radiother Oncol 104(1):119–124CrossRefPubMed
9.
Zurück zum Zitat Starke RM, Williams BJ, Jane JA Jr, Sheehan JP (2012) Gamma Knife surgery for patients with nonfunctioning pituitary macroadenomas: predictors of tumor control, neurological deficits, and hypopituitarism. J Neurosurg 117(1):129–135CrossRefPubMed Starke RM, Williams BJ, Jane JA Jr, Sheehan JP (2012) Gamma Knife surgery for patients with nonfunctioning pituitary macroadenomas: predictors of tumor control, neurological deficits, and hypopituitarism. J Neurosurg 117(1):129–135CrossRefPubMed
10.
Zurück zum Zitat Taussky P, Kalra R, Coppens J, Mohebali J, Jensen R, Couldwell WT (2011) Endocrinological outcome after pituitary transposition (hypophysopexy) and adjuvant radiotherapy for tumors involving the cavernous sinus. J Neurosurg 115(1):55–62CrossRefPubMed Taussky P, Kalra R, Coppens J, Mohebali J, Jensen R, Couldwell WT (2011) Endocrinological outcome after pituitary transposition (hypophysopexy) and adjuvant radiotherapy for tumors involving the cavernous sinus. J Neurosurg 115(1):55–62CrossRefPubMed
11.
Zurück zum Zitat Vladyka V, Liscak R, Novotny J Jr, Marek J, Jezkova J (2003) Radiation tolerance of functioning pituitary tissue in Gamma Knife surgery for pituitary adenomas. Neurosurgery 52(2):309–316CrossRefPubMed Vladyka V, Liscak R, Novotny J Jr, Marek J, Jezkova J (2003) Radiation tolerance of functioning pituitary tissue in Gamma Knife surgery for pituitary adenomas. Neurosurgery 52(2):309–316CrossRefPubMed
Metadaten
Titel
Radiosurgery for infundibulum adenoma: stalk dose implications
verfasst von
Jennifer D. Sokolowski
Or Cohen-Inbar
Jason P. Sheehan
Publikationsdatum
19.07.2016
Verlag
Springer Vienna
Erschienen in
Acta Neurochirurgica / Ausgabe 9/2016
Print ISSN: 0001-6268
Elektronische ISSN: 0942-0940
DOI
https://doi.org/10.1007/s00701-016-2894-1

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