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01.11.2010 | Radiation Oncology | Ausgabe 11/2010

Annals of Surgical Oncology 11/2010

Radiosurgery of Liver Tumors: Value of Robotic Radiosurgical Device to Treat Liver Tumors

Zeitschrift:
Annals of Surgical Oncology > Ausgabe 11/2010
Autoren:
MD Sebastian Stintzing, MD, PhD Ralf-Thorsten Hoffmann, MD, PhD Volker Heinemann, MD Markus Kufeld, MD, PhD Markus Rentsch, MD, PhD Alexander Muacevic

Abstract

Background

The treatment of isolated liver metastases has become a rapidly developing field with many new, technically advanced methods. Here we present the therapeutic efficacy of a robotic radiosurgery for local control of liver metastases from solid tumors.

Methods

Patients with tumorous lesions to the liver, not qualifying for surgery, were treated with single-session radiosurgery (24 Gy) that used robotic image-guided real-time tumor tracking. All detectable lesions had to be irradiated. In a prospective analysis, follow-up was performed by magnetic resonance imaging scanning 2 months after the treatment, and subsequently at 3-month intervals to evaluate local control. For inclusion into the radiosurgery treatment protocol, tumor volumes had to be <90 ml.

Results

Thirty-six patients (median age, 65 years) with a total of 54 target lesions were evaluated. Single lesions were treated in 23 patients and multiple targets in 13 patients. Metastases originated from colon cancer (n = 19), ovarian cancer (n = 3), pancreatic cancer (n = 2), breast cancer (n = 2), and others (n = 6). Four lesions were of primary liver origin (hepatocellular carcinoma and cholangiocellular carcinoma). Median tumor volume was 18 ml (range, 2.2–90 ml). The median follow-up was 21.3 months. The disease of 25 patients (69.4%) showed complete or partial local response, 6 patients (16.7%) had stable lesions, and 5 patients (14%) experienced local recurrence. Grade 2–4 adverse events due to radiation treatment were not observed.

Conclusions

Robotic radiosurgery with image-guided real-time tumor tracking of liver neoplasm is a new and promising approach for patients with disease that is not eligible for surgical resection and might enhance the possibilities of multidisciplinary oncological treatment concepts.

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