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15.06.2017 | Retinal Disorders | Ausgabe 10/2017

Graefe's Archive for Clinical and Experimental Ophthalmology 10/2017

Ranibizumab versus dexamethasone implant for central retinal vein occlusion: the RANIDEX study

Zeitschrift:
Graefe's Archive for Clinical and Experimental Ophthalmology > Ausgabe 10/2017
Autoren:
Irini Chatziralli, George Theodossiadis, Stamatina A. Kabanarou, Efstratios Parikakis, Tina Xirou, Panagiotis Mitropoulos, Panagiotis Theodossiadis

Abstract

Purpose

To compare intravitreal ranibizumab and dexamethasone implant in patients with macular edema (ME) secondary to central retinal vein occlusion (CRVO).

Methods

Participants were 42 treatment naive patients with ME due to CRVO, who received either intravitreal 0.5 mg ranibizumab (n = 25) or intravitreal 0.7 mg dexamethasone implant (n = 17). The main outcomes included the mean change in best corrected visual acuity (BCVA) and central subfield thickness (CST) at month 12 compared to baseline in the two groups.

Results

At month 12, there was no statistically significant difference in BCVA and CST change between the two groups. However, there was recurrence in ME at month 5 in the dexamethasone group.

Conclusions

Both ranibizumab and dexamethasone implant were found to be safe and effective at the 12-month follow-up in patients with ME secondary to CRVO. Since there was a recurrence in ME at month 5 in the dexamethasone group, we suggested that intravitreal injection of dexamethasone implant should be potentially administered sooner than 6 months.

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