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Archives of Osteoporosis

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01.12.2023 | Original Article

Rapid trabecular bone growth in puberty associated with stiffer arteries in adulthood – longitudinal study on healthy young males

verfasst von: Juta Kraav, Maksim Zagura, Liina Remmel, Evelin Mäestu, Jaak Jürimäe, Vallo Tillmann

Erschienen in: Archives of Osteoporosis | Ausgabe 1/2023

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Abstract

Summary

Longitudinal bone content data from puberty to adulthood was assessed in 102 healthy males and associations with arterial health in adulthood was analysed. Bone growth in puberty was related to arterial stiffening and final bone mineral content to decreased arterial stiffness. Relationships with arterial stiffness were dependent on the studied bone regions.

Introduction

Our aim was to assess the relationships between arterial parameters in adulthood and bone parameters in several locations longitudinally from puberty to 18-years and cross-sectionally at 18-years.

Methods

102 healthy male data from a 7-year follow—up study was used to analyse total body (TB), femoral neck (FN) and lumbar spine (LS) mineral content and density by DXA, carotid intima-media thickness (cIMT) by ultrasound, carotid-femoral pulse wave velocity (cfPWV) and heart rate adjusted augmentation index (AIxHR75) by applanation tonometry.

Results

Linear regression analysis revealed negative associations between LS bone mineral density (BMD) and cfPWV [ß=-1.861, CI -3.589, -0.132, p=0.035] which remained significant [ß=-2.679, CI -4.837, -0.522, p=0.016] after adjustment to smoking, lean mass, weight category, pubertal stage, physical fitness, and activity. For AIxHR75 similar results were present [ß=-0.286, CI -0.553, -0.020, p=0.035], but were dependent on confounders. Analysis on pubertal bone growth speed showed independent positive associations to AIxHR75 between Δ FN bone mineral apparent density (BMAD) [ß=672.50, CI 348.07, 996.93, p<0.001] and Δ LS BMAD [ß=700.40, CI 57.384, 1343.423, p=0.033]. Further analysis combining pubertal bone growth and adulthood BMC revealed that the relationships of AIxHR75 with LS BMC and ΔFN BMAD were independent of each other.

Conclusion

Trabecular bone regions like lumbar spine and femoral neck, showed stronger relationships with arterial stiffness. Rapid bone growth in puberty is related to arterial stiffening, while final bone mineral content relates to decreased arterial stiffness. These results could indicate that bone metabolism is independently associated with arterial stiffness rather than bone and arteries just having common traits of growth and maturation.

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Titel: Rapid trabecular bone growth in puberty associated with stiffer arteries in adulthood – longitudinal study on healthy young males
verfasst von: Juta Kraav
Maksim Zagura
Liina Remmel
Evelin Mäestu
Jaak Jürimäe
Vallo Tillmann
Publikationsdatum: 01.12.2023
Verlag: Springer London
Erschienen in: Archives of Osteoporosis / Ausgabe 1/2023
Print ISSN: 1862-3522
Elektronische ISSN: 1862-3514
DOI: https://doi.org/10.1007/s11657-023-01257-3

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Rapid trabecular bone growth in puberty associated with stiffer arteries in adulthood – longitudinal study on healthy young males

Abstract

Summary

Introduction

Methods

Results

Conclusion

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Springer Medizin

Abstract

Summary

Introduction

Methods

Results

Conclusion

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