Why carry out this study?
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Atopic dermatitis (AD) often affects multiple body regions and is associated with a high burden for patients when exposed skin areas are involved. |
Rapid and effective treatment of AD across multiple body regions is an unmet need, especially in body areas that are difficult to treat, such as the head and neck area. |
This post hoc analysis investigated the temporal and regional patterns of clinical improvement in AD with abrocitinib in JADE COMPARE, a phase 3, multicenter, randomized, double-blind, double-dummy trial that evaluated the efficacy and safety of abrocitinib 200 mg once daily, abrocitinib 100 mg once daily, dupilumab 300 mg subcutaneous injection every 2 weeks, and placebo, combined with background medicated topical therapy in adult patients with moderate-to-severe AD. |
What was learned from the study?
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Eczema Area and Severity Index body region scores significantly improved with abrocitinib 200 mg and 100 mg versus placebo at week 2 and were maintained up to 16 weeks. |
Abrocitinib may be useful in patients with AD that affects difficult-to-treat anatomical areas or who require a rapid response. |
Digital Features
Introduction
Methods
Study Design and Patient Eligibility
Treatment
Assessments
Statistical Analyses
Results
Baseline Demographics and Disease Characteristics
Patient demographics | Placebo (N = 131) | Abrocitinib 100 mg QD (N = 238) | Abrocitinib 200 mg QD (N = 226) | Dupilumab 300 mg Q2W (N = 242) |
---|---|---|---|---|
Age, years, mean (SD) | 37.4 (15.2) | 37.3 (14.8) | 38.8 (14.5) | 37.1 (14.6) |
Female, n (%) | 54 (41.2) | 118 (49.6) | 122 (54.0) | 134 (55.4) |
Race, n (%) | ||||
White | 87 (66.4) | 182 (76.5) | 161 (71.2) | 176 (72.7) |
Black | 6 (4.6) | 6 (2.5) | 9 (4.0) | 14 (5.8) |
Asian | 31 (23.7) | 48 (20.2) | 53 (23.5) | 46 (19.0) |
Other | 7 (5.4) | 2 (0.8) | 3 (1.3) | 6 (2.4) |
Placebo (N = 131) | Abrocitinib 100 mg QD (N = 238) | Abrocitinib 200 mg QD (N = 226) | Dupilumab 300 mg Q2W (N = 242) | |
---|---|---|---|---|
Duration of AD, years, mean (SD) | 21.4 (14.4) | 22.7 (16.3) | 23.4 (15.6) | 22.8 (14.8) |
IGAa, n (%) | ||||
Moderate | 88 (67.2) | 153 (64.3) | 138 (61.1) | 162 (66.9) |
Severe | 43 (32.8) | 85 (35.7) | 88 (38.9) | 80 (33.1) |
%BSA affected, mean (SD) | 48.9 (24.9) | 48.1 (23.1) | 50.8 (23.0) | 46.5 (22.1) |
EASIb, mean (SD) | 31.0 (12.6) | 30.3 (13.5) | 32.1 (13.1) | 30.4 (12.0) |
Head and neck (max 7.2) | 3.0 (1.6) | 2.8 (1.7) | 2.9 (1.6) | 2.9 (1.6) |
Trunk (max 21.6) | 8.9 (4.6) | 8.4 (4.5) | 9.1 (4.7) | 8.5 (4.9) |
Upper limbs (max 14.4) | 7.1 (3.0) | 6.8 (3.3) | 7.3 (3.3) | 6.8 (2.9) |
Lower limbs (max 28.8) | 11.8 (6.8) | 12.3 (7.2) | 12.7 (6.6) | 12.0 (6.1) |
SCORADc, mean (SD) | 67.9 (12.0) | 66.8 (13.8) | 69.3 (12.7) | 67.9 (11.4) |
Time to Achieve EASI-75 and EASI-90 Responses by Body Region
Placebo | Abrocitinib 100 mg QD | Abrocitinib 200 mg QD | Dupilumab 300 mg Q2W | |
---|---|---|---|---|
Median time to EASI-75 in days (95% CI) | ||||
Head and neck | 111 (83–114) | 57 (31–58) | 29 (29–32) | 57 (56–83) |
p = 0.0002 vs. placebo | p < 0.0001 vs. placebo | |||
Trunk | 87 (84–114) | 32 (29–57) | 29 (NE-NE) | 43 (30–57) |
p < 0.0001 vs. placebo | p < 0.0001 vs. placebo | |||
Upper limbs | 115 (114-NE) | 56 (30–57) | 29 (29–30) | 57 (56–59) |
p < 0.0001 vs. placebo | p < 0.0001 vs. placebo | |||
Lower limbs | 114 (87–117) | 30 (29–54) | 29 (29–30) | 57 (55–59) |
p < 0.0001 vs. placebo | p < 0.0001 vs. placebo | |||
Median time to EASI-90 in days (95% CI) | ||||
Head and neck | NE (113-NE) | 110 (85–114) | 57 (57–84) | 112 (85–114) |
p = 0.0056 vs. placebo | p < 0.0001 vs. placebo | |||
Trunk | NE (114-NE) | 85 (66–112) | 57 (32–58) | 85 (63–112) |
p < 0.0001 vs. placebo | p < 0.0001 vs. placebo | |||
Upper limbs | 117 (117-NE) | 113 (85-NE) | 58 (57–85) | 114 (112–115) |
p < 0.0001 vs. placebo | p < 0.0001 vs. placebo | |||
Lower limbs | NE (NE-NE) | 83 (58–88) | 57 (57–60) | 113 (86–115) |
p < 0.0001 vs. placebo | p < 0.0001 vs. placebo |