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Erschienen in: Clinical Journal of Gastroenterology 1/2019

12.07.2018 | Case Report

Rare case of a gallbladder neuroendocrine carcinoma

verfasst von: Masakuni Fujii, Hiroaki Saito, Junji Shiode

Erschienen in: Clinical Journal of Gastroenterology | Ausgabe 1/2019

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Abstract

There are no neuroectodermal cells in the gallbladder mucosa. Therefore, gallbladder neuroendocrine carcinoma (NEC) is extremely rare and has a poor prognosis. We report a case of a Japanese man in his 60s with this disease. The patient visited a family doctor for epigastralgia. Blood tests showed no abnormalities, including tumor markers, such as CEA and CA19-9. Abdominal ultrasonography (US) showed a low-echoic mass, 39 × 30 mm, with clear boundaries to the liver from the fundus of the gallbladder. Contrast-enhanced computed tomography showed that the tumor was enhanced early and washed out. Diffusion-weighted MRI showed a high signal. We suspected liver invasion of gallbladder cancer and performed a cholecystectomy, S4 and S5 hepatectomy, and lymphadenectomy. The resected whitish tumor was 29 × 22 mm. The tumor cells had honeycomb growth to the liver from the gallbladder. Tumor cells were poorly differentiated, and there was no stricture of the gland duct. Immunostaining showed that the tumor cells were positive for CD56, chromogranin A and synaptophysin, and about 30% were positive for Ki-67. Our diagnosis was gallbladder NEC with liver invasion. Although most malignant gallbladder tumors are adenocarcinomas, this case indicates that gallbladder NEC should be considered as a differential diagnosis of gallbladder tumor.
Literatur
1.
Zurück zum Zitat Rothenstein J, Cleary SP, Pond GR, et al. Neuroendocrine tumors of the gastrointestinal tract: a decade of experience at the Princess Margaret Hospital. Am J Clin Oncol. 2008;31:64–70.CrossRefPubMed Rothenstein J, Cleary SP, Pond GR, et al. Neuroendocrine tumors of the gastrointestinal tract: a decade of experience at the Princess Margaret Hospital. Am J Clin Oncol. 2008;31:64–70.CrossRefPubMed
2.
Zurück zum Zitat Oberg K. Diagnostic work-up of gastroenteropancreatic neuroendocrine tumors. Clinics (Sao Paulo). 2012;67:109–12.CrossRef Oberg K. Diagnostic work-up of gastroenteropancreatic neuroendocrine tumors. Clinics (Sao Paulo). 2012;67:109–12.CrossRef
3.
Zurück zum Zitat Modlin IM, Lye KD, Kidd M. A 5-decade analysis of 13,715 carcinoid tumors. Cancer. 2003;97:934–59.CrossRefPubMed Modlin IM, Lye KD, Kidd M. A 5-decade analysis of 13,715 carcinoid tumors. Cancer. 2003;97:934–59.CrossRefPubMed
4.
Zurück zum Zitat Modlin IM, Shapiro MD, Kidd M. An analysis of rare carcinoid tumors: clarifying these clinical conundrums. World J Surg. 2005;29:92–101.CrossRefPubMed Modlin IM, Shapiro MD, Kidd M. An analysis of rare carcinoid tumors: clarifying these clinical conundrums. World J Surg. 2005;29:92–101.CrossRefPubMed
5.
Zurück zum Zitat Yao JC, Hassan M, Phan A, et al. One hundred years after “carcinoid”: epidemiology of and prognostic factors for neuroendocrine tumors in 35,825 cases in the United States. J Clin Oncol. 2008;26:3063–72.CrossRefPubMed Yao JC, Hassan M, Phan A, et al. One hundred years after “carcinoid”: epidemiology of and prognostic factors for neuroendocrine tumors in 35,825 cases in the United States. J Clin Oncol. 2008;26:3063–72.CrossRefPubMed
6.
Zurück zum Zitat Chen C, Wang L, Liu X, et al. Gallbladder neuroendocrine carcinoma: report of 10 cases and comparision of clinicopathologic features with gallbladder adenocarcinoma. Int J Clin Exp Pathol. 2015;8:8218–8226PubMedPubMedCentral Chen C, Wang L, Liu X, et al. Gallbladder neuroendocrine carcinoma: report of 10 cases and comparision of clinicopathologic features with gallbladder adenocarcinoma. Int J Clin Exp Pathol. 2015;8:8218–8226PubMedPubMedCentral
7.
Zurück zum Zitat Hauso O, Gustafsson BI, Kidd M, et al. Neuroendocrine tumor epidemiology: contrasting Norway and North America. Cancer. 2008;113:2655–64.CrossRefPubMed Hauso O, Gustafsson BI, Kidd M, et al. Neuroendocrine tumor epidemiology: contrasting Norway and North America. Cancer. 2008;113:2655–64.CrossRefPubMed
9.
Zurück zum Zitat Amin MB, Greene FL, Edge SB, et al. The Eighth Edition AJCC Cancer Staging Manual: Continuing to build a bridge from a population-based to a more “personalized” approach to cancer staging. CA Cancer J Clin. 2017;67:93–9.CrossRefPubMed Amin MB, Greene FL, Edge SB, et al. The Eighth Edition AJCC Cancer Staging Manual: Continuing to build a bridge from a population-based to a more “personalized” approach to cancer staging. CA Cancer J Clin. 2017;67:93–9.CrossRefPubMed
11.
Zurück zum Zitat Hu HJ, Zhou RX, Tan YQ, et al. Coexisting cancers: a mixture of neuroendocrine carcinoma and adenocarcinoma in the gallbladder: A case report. Medicine (Baltimore). 2016;95:5281.CrossRef Hu HJ, Zhou RX, Tan YQ, et al. Coexisting cancers: a mixture of neuroendocrine carcinoma and adenocarcinoma in the gallbladder: A case report. Medicine (Baltimore). 2016;95:5281.CrossRef
12.
Zurück zum Zitat Albores-Saavedra J. Carcinoid tumors and small-cell carcinomas of the gallbladder and extrahepatic bile ducts: a comparative study based on 221 cases from the Surveillance, Epidemiology, and End Results Program. Ann Diagn Pathol. 2009;13:378–83.CrossRefPubMed Albores-Saavedra J. Carcinoid tumors and small-cell carcinomas of the gallbladder and extrahepatic bile ducts: a comparative study based on 221 cases from the Surveillance, Epidemiology, and End Results Program. Ann Diagn Pathol. 2009;13:378–83.CrossRefPubMed
13.
Zurück zum Zitat Nemenqani DM, Fuloria J, Karam RA, et al. Gallbladder Neuroendocrine Neoplasms: A Case Report of Gallbladder Small Cell Carcinoma. J Gastrointest Cancer. 2016;47:432–5.CrossRefPubMed Nemenqani DM, Fuloria J, Karam RA, et al. Gallbladder Neuroendocrine Neoplasms: A Case Report of Gallbladder Small Cell Carcinoma. J Gastrointest Cancer. 2016;47:432–5.CrossRefPubMed
14.
Zurück zum Zitat Maitra A, Tascilar M, Hruban RH, et al. Small cell carcinoma of the gallbladder: a clinicopathologic, immunohistochemical, and molecular pathology study of 12 cases. Am J Surg Pathol. 2001;25:595–601.CrossRefPubMed Maitra A, Tascilar M, Hruban RH, et al. Small cell carcinoma of the gallbladder: a clinicopathologic, immunohistochemical, and molecular pathology study of 12 cases. Am J Surg Pathol. 2001;25:595–601.CrossRefPubMed
15.
16.
Zurück zum Zitat Binderup T, Knigge U, Loft A, et al. Functional imaging of neuroendocrine tumors: a head-to-head comparison of somatostatin receptor scintigraphy, 123I-MIBG scintigraphy, and 18F-FDG PET. J Nucl Med. 2010;51:704–12.CrossRefPubMed Binderup T, Knigge U, Loft A, et al. Functional imaging of neuroendocrine tumors: a head-to-head comparison of somatostatin receptor scintigraphy, 123I-MIBG scintigraphy, and 18F-FDG PET. J Nucl Med. 2010;51:704–12.CrossRefPubMed
17.
Zurück zum Zitat Garin E, Le Jeune F, Devillers A, et al. Predictive value of 18F-FDG PET and somatostatin receptor scintigraphy in patients with metastatic endocrine tumors. J Nucl Med. 2009;50:858–64.CrossRefPubMed Garin E, Le Jeune F, Devillers A, et al. Predictive value of 18F-FDG PET and somatostatin receptor scintigraphy in patients with metastatic endocrine tumors. J Nucl Med. 2009;50:858–64.CrossRefPubMed
18.
Zurück zum Zitat Kubota K, Okasaki M, Minamimoto R, et al. Lesion-based analysis of (18)F-FDG uptake and (111)In-Pentetreotide uptake by neuroendocrine tumors. Ann Nucl Med. 2014;28:1004–10.CrossRefPubMedPubMedCentral Kubota K, Okasaki M, Minamimoto R, et al. Lesion-based analysis of (18)F-FDG uptake and (111)In-Pentetreotide uptake by neuroendocrine tumors. Ann Nucl Med. 2014;28:1004–10.CrossRefPubMedPubMedCentral
19.
Zurück zum Zitat Hashim YM, Trinkaus KM, Linehan DC, et al. Regional lymphadenectomy is indicated in the surgical treatment of pancreatic neuroendocrine tumors (PNETs). Ann Surg. 2014;259:197–203.CrossRefPubMed Hashim YM, Trinkaus KM, Linehan DC, et al. Regional lymphadenectomy is indicated in the surgical treatment of pancreatic neuroendocrine tumors (PNETs). Ann Surg. 2014;259:197–203.CrossRefPubMed
20.
Zurück zum Zitat Papotti M, Cassoni P, Sapino A, et al. Large cell neuroendocrine carcinoma of the gallbladder: report of two cases. Am J Surg Pathol. 2000;24:1424–8.CrossRefPubMed Papotti M, Cassoni P, Sapino A, et al. Large cell neuroendocrine carcinoma of the gallbladder: report of two cases. Am J Surg Pathol. 2000;24:1424–8.CrossRefPubMed
21.
Zurück zum Zitat Jun SR, Lee JM, Han JK, et al. High-grade neuroendocrine carcinomas of the gallbladder and bile duct: Report of four cases with pathological correlation. J Comput Assist Tomogr. 2006;30:604–9.CrossRefPubMed Jun SR, Lee JM, Han JK, et al. High-grade neuroendocrine carcinomas of the gallbladder and bile duct: Report of four cases with pathological correlation. J Comput Assist Tomogr. 2006;30:604–9.CrossRefPubMed
22.
Zurück zum Zitat Noske A, Pahl S. Combined adenosquamous and large-cell neuroendocrine carcinoma of the gallbladder. Virchows Arch. 2006;449:135–6.CrossRefPubMed Noske A, Pahl S. Combined adenosquamous and large-cell neuroendocrine carcinoma of the gallbladder. Virchows Arch. 2006;449:135–6.CrossRefPubMed
23.
Zurück zum Zitat Oshiro H, Matsuo K, Mawatari H, et al. Mucin-producing gallbladder adenocarcinoma with focal small cell and large cell neuroendocrine differentiation associated with pancreaticobiliary maljunction. Pathol Int. 2008;58:780–6.CrossRefPubMed Oshiro H, Matsuo K, Mawatari H, et al. Mucin-producing gallbladder adenocarcinoma with focal small cell and large cell neuroendocrine differentiation associated with pancreaticobiliary maljunction. Pathol Int. 2008;58:780–6.CrossRefPubMed
24.
Zurück zum Zitat Shimono C, Suwa K, Sato M, et al. Large cell neuroendocrine carcinoma of the gallbladder: long survival achieved by multimodal treatment. Int J Clin Oncol. 2009;14:351–5.CrossRefPubMed Shimono C, Suwa K, Sato M, et al. Large cell neuroendocrine carcinoma of the gallbladder: long survival achieved by multimodal treatment. Int J Clin Oncol. 2009;14:351–5.CrossRefPubMed
25.
Zurück zum Zitat Iype S, Mirza TA, Propper DJ, et al. Neuroendocrine tumours of the gallbladder: three cases and a review of the literature. Postgrad Med J. 2009;85:213–8.CrossRefPubMed Iype S, Mirza TA, Propper DJ, et al. Neuroendocrine tumours of the gallbladder: three cases and a review of the literature. Postgrad Med J. 2009;85:213–8.CrossRefPubMed
26.
Zurück zum Zitat Lin D, Suwantarat N, Kwee S, et al. Cushing’s syndrome caused by an ACTH-producing large cell neuroendocrine carcinoma of the gallbladder. World J Gastrointest Oncol. 2010;2:56–8.CrossRefPubMedPubMedCentral Lin D, Suwantarat N, Kwee S, et al. Cushing’s syndrome caused by an ACTH-producing large cell neuroendocrine carcinoma of the gallbladder. World J Gastrointest Oncol. 2010;2:56–8.CrossRefPubMedPubMedCentral
27.
Zurück zum Zitat Sato K, Imai T, Shirota Y, et al. Combined large cell neuroendocrine carcinoma and adenocarcinoma of the gallbladder. Pathol Res Pract. 2010;206:397–400.CrossRefPubMed Sato K, Imai T, Shirota Y, et al. Combined large cell neuroendocrine carcinoma and adenocarcinoma of the gallbladder. Pathol Res Pract. 2010;206:397–400.CrossRefPubMed
28.
Zurück zum Zitat Paniz Mondolfi AE, Slova D, Fan W, et al. Mixed adenoneuroendocrine carcinoma (MANEC) of the gallbladder: a possible stem cell tumor? Pathol Int. 2011;61:608–14.CrossRefPubMed Paniz Mondolfi AE, Slova D, Fan W, et al. Mixed adenoneuroendocrine carcinoma (MANEC) of the gallbladder: a possible stem cell tumor? Pathol Int. 2011;61:608–14.CrossRefPubMed
29.
Zurück zum Zitat Al-Brahim N, Albannai R. Combined large cell neuroendocrine carcinoma and adenocarcinoma of the gallbladder. Endocr Pathol. 2013;24:110–3.CrossRefPubMed Al-Brahim N, Albannai R. Combined large cell neuroendocrine carcinoma and adenocarcinoma of the gallbladder. Endocr Pathol. 2013;24:110–3.CrossRefPubMed
30.
Zurück zum Zitat Okuyama Y, Fukui A, Enoki Y, et al. A large cell neuroendocrine carcinoma of the gall bladder: diagnosis with 18FDG-PET/CT-guided biliary cytology and treatment with combined chemotherapy achieved a long-term stable condition. Jpn J Clin Oncol. 2013;43:571–4.CrossRefPubMed Okuyama Y, Fukui A, Enoki Y, et al. A large cell neuroendocrine carcinoma of the gall bladder: diagnosis with 18FDG-PET/CT-guided biliary cytology and treatment with combined chemotherapy achieved a long-term stable condition. Jpn J Clin Oncol. 2013;43:571–4.CrossRefPubMed
31.
Zurück zum Zitat Nakagawa T, Sakashita N, Ohnishi K, et al. Imprint cytological feature of large cell neuroendocrine carcinoma of the gallbladder: a case report. J Med Invest. 2013;60:149–53.CrossRefPubMed Nakagawa T, Sakashita N, Ohnishi K, et al. Imprint cytological feature of large cell neuroendocrine carcinoma of the gallbladder: a case report. J Med Invest. 2013;60:149–53.CrossRefPubMed
32.
Zurück zum Zitat Meguro Y, Fukushima N, Koizumi M, et al. A case of mixed adenoneuroendocrine carcinoma of the gallbladder arising from an intracystic papillary neoplasm associated with pancreaticobiliary maljunction. Pathol Int. 2014;64:465–71.CrossRefPubMed Meguro Y, Fukushima N, Koizumi M, et al. A case of mixed adenoneuroendocrine carcinoma of the gallbladder arising from an intracystic papillary neoplasm associated with pancreaticobiliary maljunction. Pathol Int. 2014;64:465–71.CrossRefPubMed
33.
Zurück zum Zitat Russo S, Russo F, Maiello FM, et al. Biphasic large cell neuroendocrine carcinoma–pure mucinous carcinoma of the gallbladder (MANEC): a unique combination. Pathologica. 2012;104:185–9.PubMed Russo S, Russo F, Maiello FM, et al. Biphasic large cell neuroendocrine carcinoma–pure mucinous carcinoma of the gallbladder (MANEC): a unique combination. Pathologica. 2012;104:185–9.PubMed
34.
Zurück zum Zitat Liu W, Wang L, He XD, et al. Mixed large cell neuroendocrine carcinoma and adenocarcinoma of the gallbladder: a case report and brief review of the literature. World J Surg Oncol. 2015;13:114.CrossRefPubMedPubMedCentral Liu W, Wang L, He XD, et al. Mixed large cell neuroendocrine carcinoma and adenocarcinoma of the gallbladder: a case report and brief review of the literature. World J Surg Oncol. 2015;13:114.CrossRefPubMedPubMedCentral
35.
Zurück zum Zitat Tang LH, Basturk O, Sue JJ, et al. A practical approach to the classification of WHO grade 3 (G3) well-differentiated neuroendocrine tumor (WD-NET) and poorly differentiated neuroendocrine carcinoma (PD-NEC) of the pancreas. Am J Surg Pathol. 2016;40:1192–202.CrossRefPubMedPubMedCentral Tang LH, Basturk O, Sue JJ, et al. A practical approach to the classification of WHO grade 3 (G3) well-differentiated neuroendocrine tumor (WD-NET) and poorly differentiated neuroendocrine carcinoma (PD-NEC) of the pancreas. Am J Surg Pathol. 2016;40:1192–202.CrossRefPubMedPubMedCentral
Metadaten
Titel
Rare case of a gallbladder neuroendocrine carcinoma
verfasst von
Masakuni Fujii
Hiroaki Saito
Junji Shiode
Publikationsdatum
12.07.2018
Verlag
Springer Japan
Erschienen in
Clinical Journal of Gastroenterology / Ausgabe 1/2019
Print ISSN: 1865-7257
Elektronische ISSN: 1865-7265
DOI
https://doi.org/10.1007/s12328-018-0883-z

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