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European Journal of Clinical Microbiology & Infectious Diseases

Erschienen in:

04.04.2019 | Review

Rat models of colistin nephrotoxicity: previous experimental researches and future perspectives

verfasst von: Cihan Heybeli, Mehmet Ası Oktan, Zahide Çavdar

Erschienen in: European Journal of Clinical Microbiology & Infectious Diseases | Ausgabe 8/2019

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Abstract

Colistin is an old antibiotic, which is abandoned decades ago because of high nephrotoxicity rates. However, it is reintroduced to clinical medicine due to lack of newly discovered antibiotics and is still widely used for the treatment of resistant gram-negative infections. Discovering mechanisms to reduce nephrotoxicity risk is of significant importance since exposed patients may have many other factors that alter kidney functions. Several agents were evaluated in animal models of colistin nephrotoxicity as a means to prevent kidney injury. Considerable heterogeneity exists in terms of reporting colistin dosing and experimental designs. This issue leads clinicians to face difficulties in designing studies and sometimes may lead to report dosing strategies inadequately. Here, we present a review according to animal models of colistin nephrotoxicity using data gathered from previous experiments to draw attention on possible complexities that researchers may encounter.

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Titel: Rat models of colistin nephrotoxicity: previous experimental researches and future perspectives
verfasst von: Cihan Heybeli
Mehmet Ası Oktan
Zahide Çavdar
Publikationsdatum: 04.04.2019
Verlag: Springer Berlin Heidelberg
Erschienen in: European Journal of Clinical Microbiology & Infectious Diseases / Ausgabe 8/2019
Print ISSN: 0934-9723
Elektronische ISSN: 1435-4373
DOI: https://doi.org/10.1007/s10096-019-03546-7

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