Rates and correlates of medication non-adherence behaviors and attitudes in adult patients with early psychosis
- 14.10.2023
- Research
Erschienen in:
- Verfasst von
- Yuen Kiu So
- Ching Yui Chan
- Shi Cheng Fung
- Tsz Ting Lui
- Fu Chun Lau
- Kit Wa Chan
- Ho Ming Lee
- Sai Yu Lui
- Lai Ming Hui
- Eric Chen
- Wing Chung Chang
- Erschienen in
- Social Psychiatry and Psychiatric Epidemiology | Ausgabe 7/2024
Abstract
Purpose
Literature on antipsychotic medication adherence in early psychosis primarily assessed adherence behaviors and focused on young patients. There is a paucity of research investigating negative medication attitude and its determinants in the early illness course, particularly in older-aged sample. We aimed to examine prevalence and correlates of medication non-adherence behaviors and negative medication attitudes separately in adult patients with early psychosis.
Methods
One hundred ninety-nine Chinese early psychosis patients aged 26–55 years who had received three-year treatment for first psychotic episode in Hong Kong were examined. Assessments encompassing socio-demographics, premorbid adjustment, clinical and treatment profiles, self-stigma and therapeutic alliance were conducted. Patients were evaluated with Medication Compliance Questionnaire, which is a modified Chinese-translated version of Medication Adherence Rating Scale and includes items measuring adherence behaviors and attitudes towards medications.
Results
Rates of medication non-adherence and negative attitude towards medications were 38.7% and 50.8%, respectively. Multivariate regression analysis showed that more severe positive symptoms, greater self-stigma and negative medication attitude were independently associated with medication non-adherence. Negative attitude towards medications was significantly associated with younger age, higher educational attainment, diagnosis of other psychotic disorders, poorer insight, greater self-stigma and less satisfaction with communication with healthcare staff, which represented an index reflecting suboptimal therapeutic alliance.
Conclusion
Antipsychotic non-adherence and negative medication attitudes are frequently observed in adult early psychosis patients. Our findings indicate that poor insight, elevated self-stigma and suboptimal therapeutic alliance may constitute potential treatment targets for promoting medication adherence and rectifying negative medication attitudes in the early illness stage.
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- Titel
- Rates and correlates of medication non-adherence behaviors and attitudes in adult patients with early psychosis
- Verfasst von
-
Yuen Kiu So
Ching Yui Chan
Shi Cheng Fung
Tsz Ting Lui
Fu Chun Lau
Kit Wa Chan
Ho Ming Lee
Sai Yu Lui
Lai Ming Hui
Eric Chen
Wing Chung Chang
- Publikationsdatum
- 14.10.2023
- Verlag
- Springer Berlin Heidelberg
- Erschienen in
-
Social Psychiatry and Psychiatric Epidemiology / Ausgabe 7/2024
Print ISSN: 0933-7954
Elektronische ISSN: 1433-9285 - DOI
- https://doi.org/10.1007/s00127-023-02563-4
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