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Erschienen in: Indian Journal of Gastroenterology 5/2018

08.11.2018 | Editorial

Rationale of using multiplex polymerase chain reaction (PCR) panels for etiological diagnosis of infective diarrhea in the tropics

verfasst von: Ujjala Ghoshal, Nidhi Tejan

Erschienen in: Indian Journal of Gastroenterology | Ausgabe 5/2018

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Excerpt

Infectious diarrhea causes significant morbidity and mortality [1, 2]. According to the Centre for Disease Control (CDC) report, it is responsible for one in nine deaths among children globally making it second most common cause of death among children under 5 years of age [3]. Infective diarrhea can be caused by multiple pathogens, most commonly due to viruses, protozoan parasites, and bacteria. It is estimated that etiology remains unidentified in 80% of patients with acute diarrhea [4]. The infective diarrhea can present as acute diarrhea, dysentery (loose stools with blood), persistent, or chronic diarrhea including malabsorption syndrome [5, 6]. …
Literatur
1.
Zurück zum Zitat Buss SN, Leber A, Chapin K, et al. Multicenter evaluation of the BioFire FilmArray gastrointestinal panel for etiologic diagnosis of infectious gastroenteritis. J Clin Microbiol. 2015;53:915–25.CrossRef Buss SN, Leber A, Chapin K, et al. Multicenter evaluation of the BioFire FilmArray gastrointestinal panel for etiologic diagnosis of infectious gastroenteritis. J Clin Microbiol. 2015;53:915–25.CrossRef
2.
Zurück zum Zitat Das AS, Mazumder DN, Pal D, Chattopadhyay UK. A study of nosocomial diarrhea in Calcutta. Indian J Gastroenterol. 1996;15:12–3.PubMed Das AS, Mazumder DN, Pal D, Chattopadhyay UK. A study of nosocomial diarrhea in Calcutta. Indian J Gastroenterol. 1996;15:12–3.PubMed
3.
Zurück zum Zitat Hutton G, Haller L, Bartram J. Global cost-benefit analysis of water supply and sanitation interventions. J Water Health. 2007;5:481–502.CrossRef Hutton G, Haller L, Bartram J. Global cost-benefit analysis of water supply and sanitation interventions. J Water Health. 2007;5:481–502.CrossRef
4.
Zurück zum Zitat Vernacchio L, Vezina RM, Mitchell AA, Lesko SM, Plaut AG, Acheson DW. Diarrhea in American infants and young children in the community setting: incidence, clinical presentation and microbiology. Pediatr Infect Dis J. 2006;25:2–7.CrossRef Vernacchio L, Vezina RM, Mitchell AA, Lesko SM, Plaut AG, Acheson DW. Diarrhea in American infants and young children in the community setting: incidence, clinical presentation and microbiology. Pediatr Infect Dis J. 2006;25:2–7.CrossRef
5.
Zurück zum Zitat Casburn-Jones AC, Farthing MJ. Management of infectious diarrhoea. Gut. 2004;53:296–305.CrossRef Casburn-Jones AC, Farthing MJ. Management of infectious diarrhoea. Gut. 2004;53:296–305.CrossRef
6.
Zurück zum Zitat Ghoshal UC, Goel A, Ghoshal U, Jain M, Misra A, Choudhuri G. Chronic diarrhea and malabsorption due to hypogammaglobulinemia: a report on twelve patients. Indian J Gastroenterol. 2011;30:170–4.CrossRef Ghoshal UC, Goel A, Ghoshal U, Jain M, Misra A, Choudhuri G. Chronic diarrhea and malabsorption due to hypogammaglobulinemia: a report on twelve patients. Indian J Gastroenterol. 2011;30:170–4.CrossRef
8.
Zurück zum Zitat Beyhan YE, Cengiz ZT. Comparison of microscopy, ELISA, and real-time PCR for detection of Giardia intestinalis in human stool specimens. Turk J Med Sci. 2017;47:1295–9.CrossRef Beyhan YE, Cengiz ZT. Comparison of microscopy, ELISA, and real-time PCR for detection of Giardia intestinalis in human stool specimens. Turk J Med Sci. 2017;47:1295–9.CrossRef
9.
Zurück zum Zitat Lee JY, Cho SY, Hwang HSH, et al. Diagnostic yield of stool culture and predictive factors for positive culture in patients with diarrheal illness. Medicine (Baltimore). 2017;96:e7641.CrossRef Lee JY, Cho SY, Hwang HSH, et al. Diagnostic yield of stool culture and predictive factors for positive culture in patients with diarrheal illness. Medicine (Baltimore). 2017;96:e7641.CrossRef
10.
Zurück zum Zitat Rohner P, Pittet D, Pepey B, Nije-Kinge T, Auckenthaler R. Etiological agents of infectious diarrhea: implications for requests for microbial culture. J Clin Microbiol. 1997;35:1427–32.PubMedPubMedCentral Rohner P, Pittet D, Pepey B, Nije-Kinge T, Auckenthaler R. Etiological agents of infectious diarrhea: implications for requests for microbial culture. J Clin Microbiol. 1997;35:1427–32.PubMedPubMedCentral
11.
Zurück zum Zitat Koplan JP, Fineberg HV, Ferraro MJ, Rosenberg ML. Value of stool cultures. Lancet. 1980;2:413–6.CrossRef Koplan JP, Fineberg HV, Ferraro MJ, Rosenberg ML. Value of stool cultures. Lancet. 1980;2:413–6.CrossRef
12.
Zurück zum Zitat Dutta S, Chatterjee A, Dutta P, et al. Sensitivity and performance characteristics of a direct PCR with stool samples in comparison to conventional techniques for diagnosis of Shigella and enteroinvasive Escherichia coli infection in children with acute diarrhoea in Calcutta, India. J Med Microbiol. 2001;50:667–74.CrossRef Dutta S, Chatterjee A, Dutta P, et al. Sensitivity and performance characteristics of a direct PCR with stool samples in comparison to conventional techniques for diagnosis of Shigella and enteroinvasive Escherichia coli infection in children with acute diarrhoea in Calcutta, India. J Med Microbiol. 2001;50:667–74.CrossRef
13.
Zurück zum Zitat Garcia LS. Parasitology: stool specimen collection and processing. Rev Med Microbiol. 1999;10:51–63.CrossRef Garcia LS. Parasitology: stool specimen collection and processing. Rev Med Microbiol. 1999;10:51–63.CrossRef
14.
Zurück zum Zitat Shimoyama T. Stool antigen tests for the management of helicobacter pylori infection. World J Gastroenterol. 2013;19:8188–91.CrossRef Shimoyama T. Stool antigen tests for the management of helicobacter pylori infection. World J Gastroenterol. 2013;19:8188–91.CrossRef
15.
Zurück zum Zitat Humphries RM, Linscott AJ. Laboratory diagnosis of bacterial gastroenteritis. Clin Microbiol Rev. 2015;28:3–1.CrossRef Humphries RM, Linscott AJ. Laboratory diagnosis of bacterial gastroenteritis. Clin Microbiol Rev. 2015;28:3–1.CrossRef
16.
Zurück zum Zitat Fotedar R, Stark D, Beebe N, Marriott D, Ellis J, Harkness J. Laboratory diagnostic techniques for Entamoeba species. Clin Microbiol Rev. 2007;20:511–32.CrossRef Fotedar R, Stark D, Beebe N, Marriott D, Ellis J, Harkness J. Laboratory diagnostic techniques for Entamoeba species. Clin Microbiol Rev. 2007;20:511–32.CrossRef
18.
Zurück zum Zitat Ghoshal U, Shukla R, Pant P, Ghoshal UC. Frequency, diagnostic performance of coproantigen detection and genotyping of the Giardia among patients referred to a multi-level teaching hospital in northern India. Pathogens Global Health. 2016;110:316–20.CrossRef Ghoshal U, Shukla R, Pant P, Ghoshal UC. Frequency, diagnostic performance of coproantigen detection and genotyping of the Giardia among patients referred to a multi-level teaching hospital in northern India. Pathogens Global Health. 2016;110:316–20.CrossRef
19.
Zurück zum Zitat Binnicker MJ. Multiplex molecular panels for diagnosis of gastrointestinal infection: Performance, result interpretation, and cost-effectiveness. J Clin Microbiol. 2015;53:3723–8.CrossRef Binnicker MJ. Multiplex molecular panels for diagnosis of gastrointestinal infection: Performance, result interpretation, and cost-effectiveness. J Clin Microbiol. 2015;53:3723–8.CrossRef
20.
Zurück zum Zitat Khare R, Espy MJ, Cebelinski E, et al. Comparative evaluation of two commercial multiplex panels for detection of gastrointestinal pathogens by use of clinical stool specimens. J Clin Microbiol. 2014;52:3667–73.CrossRef Khare R, Espy MJ, Cebelinski E, et al. Comparative evaluation of two commercial multiplex panels for detection of gastrointestinal pathogens by use of clinical stool specimens. J Clin Microbiol. 2014;52:3667–73.CrossRef
21.
Zurück zum Zitat Goldenberg SD, Bacelar M, Brazier P, et al. A cost benefit analysis of the Luminex xTAG gastrointestinal pathogen panel for detection of infectious gastroenteritis in hospitalised patients. J Inf Secur. 2015;70:504–11. Goldenberg SD, Bacelar M, Brazier P, et al. A cost benefit analysis of the Luminex xTAG gastrointestinal pathogen panel for detection of infectious gastroenteritis in hospitalised patients. J Inf Secur. 2015;70:504–11.
22.
Zurück zum Zitat Mengelle C, Mansuy JM, Prere MF, et al. Simultaneous detection of gastro-intestinal pathogens with a multiplex Luminex-based molecular assay in stool samples from diarrhoeic patients. Clin Microbiol Infect. 2013;19:E458–65.CrossRef Mengelle C, Mansuy JM, Prere MF, et al. Simultaneous detection of gastro-intestinal pathogens with a multiplex Luminex-based molecular assay in stool samples from diarrhoeic patients. Clin Microbiol Infect. 2013;19:E458–65.CrossRef
23.
Zurück zum Zitat Piralla A, Lunghi G, Ardissino G, et al. FilmArray™ GI panel performance for the diagnosis of acute gastroenteritis or hemorragic diarrhea. BMC Microbiol. 2017;17:111.CrossRef Piralla A, Lunghi G, Ardissino G, et al. FilmArray™ GI panel performance for the diagnosis of acute gastroenteritis or hemorragic diarrhea. BMC Microbiol. 2017;17:111.CrossRef
24.
Zurück zum Zitat Coste JF, Vuiblet V, Moustapha B, et al. Microbiological diagnosis of severe diarrhea in kidney transplant recipients by use of multiplex PCR assays. J Clin Microbiol. 2013;51:1841–9.CrossRef Coste JF, Vuiblet V, Moustapha B, et al. Microbiological diagnosis of severe diarrhea in kidney transplant recipients by use of multiplex PCR assays. J Clin Microbiol. 2013;51:1841–9.CrossRef
25.
Zurück zum Zitat Alejo-Cancho I, Fernández Avilés F, Capón A, et al. Evaluation of a multiplex panel for the diagnosis of acute infectious diarrhea in immunocompromised hematologic patients. PLoS One. 2017;12:e0187458.CrossRef Alejo-Cancho I, Fernández Avilés F, Capón A, et al. Evaluation of a multiplex panel for the diagnosis of acute infectious diarrhea in immunocompromised hematologic patients. PLoS One. 2017;12:e0187458.CrossRef
27.
Zurück zum Zitat Beatty N, Nix D, August J, et al. Rapid multiplex gastrointestinal pathogen panel testing improves antibiotic stewardship in patients with suspected infectious diarrhea compared with conventional methods. Open Forum Infect Dis. 2017;4 Suppl 1:S624.CrossRef Beatty N, Nix D, August J, et al. Rapid multiplex gastrointestinal pathogen panel testing improves antibiotic stewardship in patients with suspected infectious diarrhea compared with conventional methods. Open Forum Infect Dis. 2017;4 Suppl 1:S624.CrossRef
28.
Zurück zum Zitat Rand KH, Tremblay EE, Hoidal M, Fisher LB, Grau KR, Karst SM. Multiplex gastrointestinal pathogen panels: implications for infection control. Diagn Microbiol Infect Dis. 2015;82:154–7.CrossRef Rand KH, Tremblay EE, Hoidal M, Fisher LB, Grau KR, Karst SM. Multiplex gastrointestinal pathogen panels: implications for infection control. Diagn Microbiol Infect Dis. 2015;82:154–7.CrossRef
29.
Zurück zum Zitat Halligan E, Edgeworth J, Bisnauthsing K, et al. Multiplex molecular testing for management of infectious gastroenteritis in a hospital setting: a comparative diagnostic and clinical utility study. Clin Microbiol Infect. 2014;20:O460–7.CrossRef Halligan E, Edgeworth J, Bisnauthsing K, et al. Multiplex molecular testing for management of infectious gastroenteritis in a hospital setting: a comparative diagnostic and clinical utility study. Clin Microbiol Infect. 2014;20:O460–7.CrossRef
Metadaten
Titel
Rationale of using multiplex polymerase chain reaction (PCR) panels for etiological diagnosis of infective diarrhea in the tropics
verfasst von
Ujjala Ghoshal
Nidhi Tejan
Publikationsdatum
08.11.2018
Verlag
Springer India
Erschienen in
Indian Journal of Gastroenterology / Ausgabe 5/2018
Print ISSN: 0254-8860
Elektronische ISSN: 0975-0711
DOI
https://doi.org/10.1007/s12664-018-0908-z

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