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Erschienen in: Abdominal Radiology 1/2019

28.06.2018

Reader agreement and accuracy of ultrasound features for hepatic steatosis

verfasst von: Cheng William Hong, Austin Marsh, Tanya Wolfson, Jeremy Paige, Soudabeh Fazeli Dekhordy, Alexandra N. Schlein, Elise Housman, Lisa H. Deiranieh, Charles Q. Li, Ashish P. Wasnik, Hyun-Jung Jang, Christoph F. Dietrich, Fabio Piscaglia, Giovanna Casola, Mary O’Boyle, Katherine M. Richman, Mark A. Valasek, Michael Andre, Rohit Loomba, Claude B. Sirlin

Erschienen in: Abdominal Radiology | Ausgabe 1/2019

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Abstract

Purpose

The purpose of the study is to assess the reader agreement and accuracy of eight ultrasound imaging features for classifying hepatic steatosis in adults with known or suspected hepatic steatosis.

Methods

This was an IRB-approved, HIPAA-compliant prospective study of adult patients with known or suspected hepatic steatosis. All patients signed written informed consent. Ultrasound images (Siemens S3000, 6C1HD, and 4C1 transducers) were acquired by experienced sonographers following a standard protocol. Eight readers independently graded eight features and their overall impression of hepatic steatosis on ordinal scales using an electronic case report form. Duplicated images from the 6C1HD transducer were read twice to assess intra-reader agreement. Intra-reader, inter-transducer, and inter-reader agreement were assessed using intraclass correlation coefficients (ICC). Features with the highest intra-reader agreement were selected as predictors for dichotomized histological steatosis using Classification and Regression Tree (CART) analysis, and the accuracy of the decision rule was compared to the accuracy of the radiologists’ overall impression.

Results

45 patients (18 males, 27 females; mean age 56 ± 12 years) scanned from September 2015 to July 2016 were included. Mean intra-reader ICCs ranged from 0.430 to 0.777, inter-transducer ICCs ranged from 0.228 to 0.640, and inter-reader ICCs ranged from 0.014 to 0.561. The CART decision rule selected only large hepatic vein blurring and achieved similar accuracy to the overall impression (74% to 75% and 68% to 72%, respectively).

Conclusions

Large hepatic vein blurring, liver–kidney contrast, and overall impression provided the highest reader agreement. Large hepatic vein blurring may provide the highest classification accuracy for dichotomized grading of hepatic steatosis.
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Metadaten
Titel
Reader agreement and accuracy of ultrasound features for hepatic steatosis
verfasst von
Cheng William Hong
Austin Marsh
Tanya Wolfson
Jeremy Paige
Soudabeh Fazeli Dekhordy
Alexandra N. Schlein
Elise Housman
Lisa H. Deiranieh
Charles Q. Li
Ashish P. Wasnik
Hyun-Jung Jang
Christoph F. Dietrich
Fabio Piscaglia
Giovanna Casola
Mary O’Boyle
Katherine M. Richman
Mark A. Valasek
Michael Andre
Rohit Loomba
Claude B. Sirlin
Publikationsdatum
28.06.2018
Verlag
Springer US
Erschienen in
Abdominal Radiology / Ausgabe 1/2019
Print ISSN: 2366-004X
Elektronische ISSN: 2366-0058
DOI
https://doi.org/10.1007/s00261-018-1683-0

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