To view enhanced digital content for this article go to https://doi.org/10.6084/m9.figshare.6866177.
Hair thinning occurred in 10–14% of teriflunomide-treated patients in the teriflunomide multiple sclerosis clinical development program, compared with 5% of placebo-treated patients. Our objective was to examine the clinical course of hair thinning in patients in an observational real-world project.
Patients with relapsing–remitting multiple sclerosis who reported hair thinning to healthcare professionals (HCPs) during treatment with teriflunomide were eligible for inclusion. During two office visits, one at onset of hair thinning and another at follow-up, HCPs and patients completed questionnaires that categorized hair thinning as mild, moderate, or severe, or from 0 (no hair thinning) to 10 (very severe hair thinning), respectively. At the follow-up visit, patients also rated the degree of recovery. Patients were photographed at both visits with a standardized protocol and camera.
Of the 38 patients who completed follow-up, most were women (97%) without prior history of hair thinning (87%), with the majority (68%) receiving concomitant medications potentially associated with hair thinning. The mean time to onset of hair thinning was 77 days after the first teriflunomide dose. HCPs classified the majority of hair thinning events as mild (63%) or moderate (34%), with one event classified as severe (3%). The mean patient severity perception was 5/10, and complete/near-complete resolution or marked improvement was reported by 79% of patients.
Consistent with observations from the teriflunomide clinical program, hair thinning was usually mild and occurred within the first 3 months of treatment, with most patients fully recovering while remaining on teriflunomide treatment. As with any potential adverse event, it is important to ensure appropriate expectations through patient education before treatment.
Drug Induced Hair Loss [American Hair Loss Association website]. Available at: http://www.americanhairloss.org/drug_induced_hair_loss/. Accessed May 4, 2018.
Freedman MS, Miller AE, Comi G, et al. Outcomes of the TEMSO extension study of teriflunomide: 10.5 years of clinical results. Mult Scler. 2016;22(S3):807.
Coyle PK, Khatri B, Edwards KR, et al. Teriflunomide real-world safety profile: results of the phase 4 Teri-PRO study. Mult Scler. 2016;22(S3):774.
Avonex (interferon-beta-1a). Prescribing information. Cambridge, MA: Biogen; 2016.
Betaseron (interferon beta-1b). Prescribing Information. Whippany, NJ: Bayer HealthCare Pharmaceuticals; 2016.
Bergfeld W, Mulinari-Brenner F. Hair disorders [Cleveland Clinic Center for Continuing Education website]. Available at: https://www.clevelandclinicmeded.com/medicalpubs/diseasemanagement/dermatology/hair-disorders/. Accessed May 4, 2018.
- Real-World Observational Evaluation of Hair Thinning in Patients with Multiple Sclerosis Receiving Teriflunomide: Is It an Issue in Clinical Practice?
Lori Hendin Travis
Keith R. Edwards
- Springer Healthcare
Neu im Fachgebiet Innere Medizin
Meistgelesene Bücher aus der Inneren Medizin
Mail Icon II