Skip to main content
Erschienen in: European Journal of Trauma and Emergency Surgery 1/2019

25.07.2017 | Original Article

Reamer–Irrigator–Aspirator bone graft harvesting for treatment of segmental bone loss: analysis of defect volume as independent risk factor for failure

verfasst von: W. J. Metsemakers, G. Claes, P. J. Terryn, A. Belmans, H. Hoekstra, S. Nijs

Erschienen in: European Journal of Trauma and Emergency Surgery | Ausgabe 1/2019

Einloggen, um Zugang zu erhalten

Abstract

Introduction

The management of segmental bone loss poses a significant clinical challenge. The purpose of this study was to conduct a retrospective evaluation of our experience in treating segmental bone loss, using Reamer–Irrigator–Aspirator (RIA)-harvested autologous bone graft.

Materials and methods

Between June 2008 and March 2015, 81 patients were treated with the RIA technique for multiple purposes. Inclusion criteria for this study were skeletal mature patients with segmental bone loss, due to acute trauma or non-union, who were treated with RIA-harvested bone graft. Exclusion criteria were skeletal immaturity, pathological fractures and indications for the RIA system other than bone graft harvesting. The primary outcome parameter was clinical and radiographical bone healing.

Results

During the study period, 72 patients met the inclusion criteria. In total, 39 patients (54.2%) were classified as having clinical and radiographical bone healing. Although univariate analysis could not reveal any significant influence of specific risk factors to predict the outcome, there was a trend towards statistical significance for defect volume. Further analysis indeed revealed that smaller defect volumes (< 8 cm3) had a lower risk of non-union.

Conclusions

In approximately half of our study population, the use of the RIA technique for autologous bone graft harvesting in cases of segmental bone loss resulted in a successful outcome with bone healing. Defect size seems to be a critical issue regarding the outcome. Although our results are less promising than previously published, the RIA technique has its place in the treatment algorithm of segmental bone defects.
Literatur
1.
Zurück zum Zitat Tay WH, de Steiger R, Richardson M, Gruen R, Balogh ZJ. Health outcomes of delayed union and nonunion of femoral and tibial shaft fractures. Injury. 2014;45:1653–8.CrossRefPubMed Tay WH, de Steiger R, Richardson M, Gruen R, Balogh ZJ. Health outcomes of delayed union and nonunion of femoral and tibial shaft fractures. Injury. 2014;45:1653–8.CrossRefPubMed
2.
Zurück zum Zitat Mauffrey C, Barlow BT, Smith W. Management of segmental bone defects. J Am Acad Orthop Surg. 2015;23:143–53.PubMed Mauffrey C, Barlow BT, Smith W. Management of segmental bone defects. J Am Acad Orthop Surg. 2015;23:143–53.PubMed
3.
Zurück zum Zitat Ilizarov GA. Clinical application of the tension-stress effect for limb lengthening. Clin Orthop Relat Res. 1990;250:8–26. Ilizarov GA. Clinical application of the tension-stress effect for limb lengthening. Clin Orthop Relat Res. 1990;250:8–26.
4.
Zurück zum Zitat Aronson J. Limb-lengthening, skeletal reconstruction, and bone transport with the Ilizarov method. J Bone Jt Surg Am. 1997;79:1243–58.CrossRef Aronson J. Limb-lengthening, skeletal reconstruction, and bone transport with the Ilizarov method. J Bone Jt Surg Am. 1997;79:1243–58.CrossRef
5.
Zurück zum Zitat Stafford PR, Norris BL. Reamer-irrigator-aspirator bone graft and bi Masquelet technique for segmental bone defect nonunions: a review of 25 cases. Injury. 2010;41(Suppl 2):S72–7.CrossRefPubMed Stafford PR, Norris BL. Reamer-irrigator-aspirator bone graft and bi Masquelet technique for segmental bone defect nonunions: a review of 25 cases. Injury. 2010;41(Suppl 2):S72–7.CrossRefPubMed
6.
Zurück zum Zitat Paley D, Maar DC. Ilizarov bone transport treatment for tibial defects. J Orthop Trauma. 2000;14:76–85.CrossRefPubMed Paley D, Maar DC. Ilizarov bone transport treatment for tibial defects. J Orthop Trauma. 2000;14:76–85.CrossRefPubMed
7.
Zurück zum Zitat Giannoudis PV, Calori GM, Begue T, Schmidmaier G. Bone regeneration strategies: current trends but what the future holds? Injury. 2013;44(Suppl 1):S1–2.CrossRefPubMed Giannoudis PV, Calori GM, Begue T, Schmidmaier G. Bone regeneration strategies: current trends but what the future holds? Injury. 2013;44(Suppl 1):S1–2.CrossRefPubMed
8.
Zurück zum Zitat Moghaddam A, Zietzschmann S, Bruckner T, Schmidmaier G. Treatment of atrophic tibia non-unions according to ‘diamond concept’: results of one- and two-step treatment. Injury. 2015;46(Suppl 4):S39–50.CrossRefPubMed Moghaddam A, Zietzschmann S, Bruckner T, Schmidmaier G. Treatment of atrophic tibia non-unions according to ‘diamond concept’: results of one- and two-step treatment. Injury. 2015;46(Suppl 4):S39–50.CrossRefPubMed
9.
Zurück zum Zitat Newman JT, Stahel PF, Smith WR, Resende GV, Hak DJ, Morgan SJ. A new minimally invasive technique for large volume bone graft harvest for treatment of fracture nonunions. Orthopedics. 2008;31:257–61.CrossRefPubMed Newman JT, Stahel PF, Smith WR, Resende GV, Hak DJ, Morgan SJ. A new minimally invasive technique for large volume bone graft harvest for treatment of fracture nonunions. Orthopedics. 2008;31:257–61.CrossRefPubMed
10.
Zurück zum Zitat Masquelet AC, Fitoussi F, Begue T, Muller GP. Reconstruction of the long bones by the induced membrane and spongy autograft. Ann Chir Plast Esthet. 2000;45:346–53.PubMed Masquelet AC, Fitoussi F, Begue T, Muller GP. Reconstruction of the long bones by the induced membrane and spongy autograft. Ann Chir Plast Esthet. 2000;45:346–53.PubMed
11.
Zurück zum Zitat Cox G, Jones E, McGonagle D, Giannoudis PV. Reamer-irrigator-aspirator indications and clinical results: a systematic review. Int Orthop. 2011;35:951–6.CrossRefPubMedPubMedCentral Cox G, Jones E, McGonagle D, Giannoudis PV. Reamer-irrigator-aspirator indications and clinical results: a systematic review. Int Orthop. 2011;35:951–6.CrossRefPubMedPubMedCentral
12.
Zurück zum Zitat McCall TA, Brokaw DS, Jelen BA, Scheid DK, Scharfenberger AV, Maar DC, et al. Treatment of large segmental bone defects with reamer-irrigator-aspirator bone graft: technique and case series. Orthop Clin North Am. 2010;41:63–73 (table of contents).CrossRefPubMed McCall TA, Brokaw DS, Jelen BA, Scheid DK, Scharfenberger AV, Maar DC, et al. Treatment of large segmental bone defects with reamer-irrigator-aspirator bone graft: technique and case series. Orthop Clin North Am. 2010;41:63–73 (table of contents).CrossRefPubMed
13.
Zurück zum Zitat Masquelet AC, Begue T. The concept of induced membrane for reconstruction of long bone defects. Orthop Clin North Am. 2010;41:27–37 (table of contents).CrossRefPubMed Masquelet AC, Begue T. The concept of induced membrane for reconstruction of long bone defects. Orthop Clin North Am. 2010;41:27–37 (table of contents).CrossRefPubMed
14.
Zurück zum Zitat Biewener A, Aschenbrenner U, Rammelt S, Grass R, Zwipp H. Impact of helicopter transport and hospital level on mortality of polytrauma patients. J trauma. 2004;56:94–8.CrossRefPubMed Biewener A, Aschenbrenner U, Rammelt S, Grass R, Zwipp H. Impact of helicopter transport and hospital level on mortality of polytrauma patients. J trauma. 2004;56:94–8.CrossRefPubMed
15.
Zurück zum Zitat Marsh JL, Slongo TF, Agel J, Broderick JS, Creevey W, DeCoster TA, et al. Fracture and dislocation classification compendium-2007: orthopaedic Trauma Association classification, database and outcomes committee. J Orthop Trauma. 2007;21:S1–133.CrossRefPubMed Marsh JL, Slongo TF, Agel J, Broderick JS, Creevey W, DeCoster TA, et al. Fracture and dislocation classification compendium-2007: orthopaedic Trauma Association classification, database and outcomes committee. J Orthop Trauma. 2007;21:S1–133.CrossRefPubMed
16.
Zurück zum Zitat Gustilo RB, Anderson JT. Prevention of infection in the treatment of one thousand and twenty-five open fractures of long bones: retrospective and prospective analyses. J Bone Jt Surg Am. 1976;58:453–8.CrossRef Gustilo RB, Anderson JT. Prevention of infection in the treatment of one thousand and twenty-five open fractures of long bones: retrospective and prospective analyses. J Bone Jt Surg Am. 1976;58:453–8.CrossRef
17.
Zurück zum Zitat Dellinger EP, Miller SD, Wertz MJ, Grypma M, Droppert B, Anderson PA. Risk of infection after open fracture of the arm or leg. Arch Surg. 1988;123:1320–7.CrossRefPubMed Dellinger EP, Miller SD, Wertz MJ, Grypma M, Droppert B, Anderson PA. Risk of infection after open fracture of the arm or leg. Arch Surg. 1988;123:1320–7.CrossRefPubMed
18.
Zurück zum Zitat Horan TC, Gaynes RP, Martone WJ, Jarvis WR, Emori TG. CDC definitions of nosocomial surgical site infections, 1992: a modification of CDC definitions of surgical wound infections. Infect Control Hosp Epidemiol Off J Soc Hosp Epidemiol Am. 1992;13:606–8.CrossRef Horan TC, Gaynes RP, Martone WJ, Jarvis WR, Emori TG. CDC definitions of nosocomial surgical site infections, 1992: a modification of CDC definitions of surgical wound infections. Infect Control Hosp Epidemiol Off J Soc Hosp Epidemiol Am. 1992;13:606–8.CrossRef
19.
Zurück zum Zitat Metsemakers WJ, Handojo K, Reynders P, Sermon A, Vanderschot P, Nijs S. Individual risk factors for deep infection and compromised fracture healing after intramedullary nailing of tibial shaft fractures: a single centre experience of 480 patients. Injury. 2015;46:740–5.CrossRefPubMed Metsemakers WJ, Handojo K, Reynders P, Sermon A, Vanderschot P, Nijs S. Individual risk factors for deep infection and compromised fracture healing after intramedullary nailing of tibial shaft fractures: a single centre experience of 480 patients. Injury. 2015;46:740–5.CrossRefPubMed
20.
Zurück zum Zitat Giannoudis PV, Tzioupis C, Green J. Surgical techniques: how I do it? The reamer/irrigator/aspirator (RIA) system. Injury. 2009;40:1231–6.CrossRefPubMed Giannoudis PV, Tzioupis C, Green J. Surgical techniques: how I do it? The reamer/irrigator/aspirator (RIA) system. Injury. 2009;40:1231–6.CrossRefPubMed
21.
Zurück zum Zitat Akaike H. New look at statistical-model identification. IEEE Trans Autom Control. 1974;19:716–23.CrossRef Akaike H. New look at statistical-model identification. IEEE Trans Autom Control. 1974;19:716–23.CrossRef
22.
Zurück zum Zitat Calori GM, Mazza E, Colombo M, Ripamonti C. The use of bone-graft substitutes in large bone defects: any specific needs? Injury. 2011;42(Suppl 2):S56–63.CrossRefPubMed Calori GM, Mazza E, Colombo M, Ripamonti C. The use of bone-graft substitutes in large bone defects: any specific needs? Injury. 2011;42(Suppl 2):S56–63.CrossRefPubMed
23.
Zurück zum Zitat Karger C, Kishi T, Schneider L, Fitoussi L, Masquelet AC, Masquelet AC, French Society of Orthopaedic Surgery, et al. Treatment of posttraumatic bone defects by the induced membrane technique. Orthop Traumatol Surg Res. 2012;98:97–102.CrossRefPubMed Karger C, Kishi T, Schneider L, Fitoussi L, Masquelet AC, Masquelet AC, French Society of Orthopaedic Surgery, et al. Treatment of posttraumatic bone defects by the induced membrane technique. Orthop Traumatol Surg Res. 2012;98:97–102.CrossRefPubMed
24.
Zurück zum Zitat Qvick LM, Ritter CA, Mutty CE, Rohrbacher BJ, Buyea CM, Anders MJ. Donor site morbidity with reamer-irrigator-aspirator (RIA) use for autogenous bone graft harvesting in a single centre 204 case series. Injury. 2013;44:1263–9.CrossRefPubMed Qvick LM, Ritter CA, Mutty CE, Rohrbacher BJ, Buyea CM, Anders MJ. Donor site morbidity with reamer-irrigator-aspirator (RIA) use for autogenous bone graft harvesting in a single centre 204 case series. Injury. 2013;44:1263–9.CrossRefPubMed
25.
Zurück zum Zitat Henrich D, Seebach C, Sterlepper E, Tauchmann C, Marzi I, Frank J. RIA reamings and hip aspirate: a comparative evaluation of osteoprogenitor and endothelial progenitor cells. Injury. 2010;41(Suppl 2):S62–8.CrossRefPubMed Henrich D, Seebach C, Sterlepper E, Tauchmann C, Marzi I, Frank J. RIA reamings and hip aspirate: a comparative evaluation of osteoprogenitor and endothelial progenitor cells. Injury. 2010;41(Suppl 2):S62–8.CrossRefPubMed
26.
Zurück zum Zitat Giannoudis PV, Gudipati S, Harwood P, Kanakaris NK. Long bone non-unions treated with the diamond concept: a case series of 64 patients. Injury. 2015;46(Suppl 8):S48–54.CrossRefPubMed Giannoudis PV, Gudipati S, Harwood P, Kanakaris NK. Long bone non-unions treated with the diamond concept: a case series of 64 patients. Injury. 2015;46(Suppl 8):S48–54.CrossRefPubMed
27.
Zurück zum Zitat Han F, Peter L, Lau ET, Thambiah J, Murphy D, Kagda FH. Reamer irrigator aspirator bone graft harvesting: complications and outcomes in an Asian population. Injury. 2015;46:2042–51.CrossRefPubMed Han F, Peter L, Lau ET, Thambiah J, Murphy D, Kagda FH. Reamer irrigator aspirator bone graft harvesting: complications and outcomes in an Asian population. Injury. 2015;46:2042–51.CrossRefPubMed
28.
Zurück zum Zitat Bhandari M, Guyatt GH, Swiontkowski MF, Tornetta P 3rd, Sprague S, Schemitsch EH. A lack of consensus in the assessment of fracture healing among orthopaedic surgeons. J Orthop Trauma. 2002;16:562–6.CrossRefPubMed Bhandari M, Guyatt GH, Swiontkowski MF, Tornetta P 3rd, Sprague S, Schemitsch EH. A lack of consensus in the assessment of fracture healing among orthopaedic surgeons. J Orthop Trauma. 2002;16:562–6.CrossRefPubMed
29.
Zurück zum Zitat Giannoudis PV, Einhorn TA, Marsh D. Fracture healing: the diamond concept. Injury. 2007;38(Suppl 4):S3–6.CrossRefPubMed Giannoudis PV, Einhorn TA, Marsh D. Fracture healing: the diamond concept. Injury. 2007;38(Suppl 4):S3–6.CrossRefPubMed
30.
Zurück zum Zitat Aro HT, Govender S, Patel AD, Hernigou P, Perera de Gregorio A, Popescu GI, et al. Recombinant human bone morphogenetic protein-2: a randomized trial in open tibial fractures treated with reamed nail fixation. J Bone Jt Surg Am. 2011;93:801–8.CrossRef Aro HT, Govender S, Patel AD, Hernigou P, Perera de Gregorio A, Popescu GI, et al. Recombinant human bone morphogenetic protein-2: a randomized trial in open tibial fractures treated with reamed nail fixation. J Bone Jt Surg Am. 2011;93:801–8.CrossRef
31.
Zurück zum Zitat Aho OM, Lehenkari P, Ristiniemi J, Lehtonen S, Risteli J, Leskela HV. The mechanism of action of induced membranes in bone repair. J Bone Jt Surg Am. 2013;95:597–604.CrossRef Aho OM, Lehenkari P, Ristiniemi J, Lehtonen S, Risteli J, Leskela HV. The mechanism of action of induced membranes in bone repair. J Bone Jt Surg Am. 2013;95:597–604.CrossRef
32.
Zurück zum Zitat Riegger C, Kropil P, Jungbluth P, Lanzman RS, Miese FR, Hakimi AR, et al. Quantitative assessment of bone defect healing by multidetector CT in a pig model. Skelet Radiol. 2012;41:531–7.CrossRef Riegger C, Kropil P, Jungbluth P, Lanzman RS, Miese FR, Hakimi AR, et al. Quantitative assessment of bone defect healing by multidetector CT in a pig model. Skelet Radiol. 2012;41:531–7.CrossRef
33.
Zurück zum Zitat Seebach E, Holschbach J, Buchta N, Bitsch RG, Kleinschmidt K, Richter W. Mesenchymal stromal cell implantation for stimulation of long bone healing aggravates Staphylococcus aureus induced osteomyelitis. Acta Biomater. 2015;21:165–77.CrossRefPubMed Seebach E, Holschbach J, Buchta N, Bitsch RG, Kleinschmidt K, Richter W. Mesenchymal stromal cell implantation for stimulation of long bone healing aggravates Staphylococcus aureus induced osteomyelitis. Acta Biomater. 2015;21:165–77.CrossRefPubMed
Metadaten
Titel
Reamer–Irrigator–Aspirator bone graft harvesting for treatment of segmental bone loss: analysis of defect volume as independent risk factor for failure
verfasst von
W. J. Metsemakers
G. Claes
P. J. Terryn
A. Belmans
H. Hoekstra
S. Nijs
Publikationsdatum
25.07.2017
Verlag
Springer Berlin Heidelberg
Erschienen in
European Journal of Trauma and Emergency Surgery / Ausgabe 1/2019
Print ISSN: 1863-9933
Elektronische ISSN: 1863-9941
DOI
https://doi.org/10.1007/s00068-017-0821-7

Weitere Artikel der Ausgabe 1/2019

European Journal of Trauma and Emergency Surgery 1/2019 Zur Ausgabe

Arthropedia

Grundlagenwissen der Arthroskopie und Gelenkchirurgie. Erweitert durch Fallbeispiele, Videos und Abbildungen. 
» Jetzt entdecken

Update Orthopädie und Unfallchirurgie

Bestellen Sie unseren Fach-Newsletter und bleiben Sie gut informiert.