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25.08.2020 | Review | Ausgabe 6/2020 Open Access

Journal of Cancer Survivorship 6/2020

Recommendations for the surveillance of cancer-related fatigue in childhood, adolescent, and young adult cancer survivors: a report from the International Late Effects of Childhood Cancer Guideline Harmonization Group

Journal of Cancer Survivorship > Ausgabe 6/2020
Salome Christen, Katharina Roser, Renée L. Mulder, Anica Ilic, Hanne C. Lie, Jacqueline J. Loonen, Anneli V. Mellblom, Leontien C. M. Kremer, Melissa M. Hudson, Louis S. Constine, Roderick Skinner, Katrin Scheinemann, Jordan Gilleland Marchak, Gisela Michel, on behalf of the IGHG psychological late effects group
Wichtige Hinweise

Electronic supplementary material

The online version of this article (https://​doi.​org/​10.​1007/​s11764-020-00904-9) contains supplementary material, which is available to authorized users.
Salome Christen and Katharina Roser shared first authors
Katrin Scheinemann, Jordan Gilleland Marchak, and Gisela Michel shared last authors

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Springer Nature remains neutral with regard to jurisdictional claims in published maps and institutional affiliations.



Cancer-related fatigue (CRF) negatively affects the lives of childhood, adolescent, and young adult (CAYA) cancer survivors. We aimed to provide an evidence-based clinical practice guideline (CPG) with internationally harmonized CRF surveillance recommendations for CAYA cancer survivors diagnosed < 30 years.


This CPG was developed by a multidisciplinary panel under the umbrella of the International Late Effects of Childhood Cancer Guideline Harmonization Group. After evaluating concordances and discordances of four existing CPGs, we performed systematic literature searches. We screened articles for eligibility, assessed quality, extracted, and summarized the data from included articles. We formulated recommendations based on the evidence and clinical judgment.


Of 3647 articles identified, 70 articles from 14 countries were included. The prevalence of CRF in CAYA cancer survivors ranged from 10–85%. We recommend that healthcare providers are aware of the risk of CRF, implement regular screening with validated measures, and recommend effective interventions to fatigued survivors.


A considerable proportion of CAYA cancer survivors suffers from CRF even years after the end of treatment.

Implications for Cancer Survivors

We recommend that healthcare providers adopt regular screening to detect and treat CRF early and positively influence survivors’ health and quality of life.

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