nach oben

Erschienen in:

17.03.2020 | Original Paper

Recurrent infective endocarditis versus first-time infective endocarditis after heart valve surgery

verfasst von: Eva Havers-Borgersen, Jawad H. Butt, Lauge Østergaard, Henning Bundgaard, Morten Smerup, Niels Eske Bruun, Gunnar H. Gislason, Christian Torp-Pedersen, Lars Køber, Emil L. Fosbøl

Erschienen in: Clinical Research in Cardiology | Ausgabe 11/2020

Einloggen, um Zugang zu erhalten

Abstract

Objective

Infective endocarditis (IE) may require heart valve surgery. It is well known that heart valve surgery itself and previous IE predispose to IE. However, data are sparse on whether the risk of IE is different among patients undergoing valve surgery due to IE and other causes (i.e. recurrent vs. first-time IE).

Methods

Using Danish nationwide registries, patients undergoing left-sided heart valve surgery in the course of an IE hospitalization (1996–2017) were identified and matched with controls undergoing left-sided heart valve surgery due to another cause than IE in a 1:1 ratio. Patients were stratified according to type of surgical valve intervention and affected valve. The comparative risk of recurrent vs. first-time IE was assessed by cumulative incidence curves and multivariable Cox regression analyses.

Results

The study population comprised 971 patients with a first-time admission for IE requiring heart valve surgery matched with 971 controls undergoing heart valve surgery due to other causes than IE. The risk of recurrent IE was significantly higher than the risk of first-time IE following heart valve surgery (5.5% and 3.0% by 10 years, hazard ratio (HR) 1.66, 95% confidence interval (CI) 1.02–2.70). The risk of IE recurrence was not significantly different comparing valve replacement and valve repair (5.5% and 5.3%, respectively, HR 1.60, 95% CI 0.71–3.60). Yet, the risk of IE recurrence was significantly higher among patients with biological versus mechanical prostheses (6.3% and 4.6%, respectively, HR 2.00, 95% CI 1.02–3.70).

Conclusions

Following heart valve surgery, the risk of recurrent IE was significantly higher than the risk of first-time IE.

Graphic abstract

Nur mit Berechtigung zugänglich

Østergaard L, Valeur N, Bundgaard H et al (2017) Temporal changes in infective endocarditis guidelines during the last 12 years: high-level evidence needed. Am Heart J 193:70–75. https://doi.org/10.1016/j.ahj.2017.07.018CrossRefPubMed

Erichsen P, Gislason GH, Bruun NE (2016) The increasing incidence of infective endocarditis in Denmark, 1994–2011. Eur J Intern Med 35:95–99. https://doi.org/10.1016/j.ejim.2016.05.021CrossRefPubMed

Moreillon P, Que Y-A (2004) Infective endocarditis. Lancet (Lond, Engl) 363:139–149. https://doi.org/10.1016/S0140-6736(03)15266-XCrossRef

Butt JH, Kragholm K, Dalager-Pedersen M et al (2018) Return to the workforce following infective endocarditis—a nationwide cohort study. Am Heart J 195:130–138. https://doi.org/10.1016/j.ahj.2017.09.009CrossRefPubMed

Baddour LM, Wilson WR, Bayer AS et al (2015) Infective endocarditis in adults: diagnosis, antimicrobial therapy, and management of complications: a scientific statement for healthcare professionals from the American Heart Association. Circulation 132:1435–1486. https://doi.org/10.1161/CIR.0000000000000296CrossRefPubMed

Ferro JM, Fonseca AC (2014) Infective endocarditis. Handb Clin Neurol 119:75–91. https://doi.org/10.1016/B978-0-7020-4086-3.00007-2CrossRefPubMed

Habib G, Lancellotti P, Antunes MJ et al (2015) 2015 ESC Guidelines for the management of infective endocarditis. Eur Heart J 44:3075–3123. https://doi.org/10.1093/eurheartj/ehv319CrossRef

Østergaard L, Valeur N, Ihlemann N et al (2018) Incidence of infective endocarditis among patients considered at high risk. Eur Heart J 39:623–629. https://doi.org/10.1093/eurheartj/ehx682CrossRefPubMed

Wallach Kildemoes H, Toft Sørensen H, Hallas J (2011) The Danish National Prescription Registry. Scand J Public Health 39:38–41. https://doi.org/10.1177/1403494810394717CrossRef

10.

Østergaard L, Adelborg K, Sundbøll J et al (2018) Positive predictive value of infective endocarditis in the Danish National Patient Registry: a validation study. BMJ Open 6:e012832. https://doi.org/10.1136/bmjopen-2016-012832CrossRef

11.

Messing JA (2012) Transcatheter aortic valve implantation. J Cardiovasc Nurs 27:356–364. https://doi.org/10.1097/JCN.0b013e31822275a8CrossRefPubMed

12.

Olesen JB, Lip GYH, Hansen ML et al (2006) Validation of risk stratification schemes for predicting stroke nationwide cohort study. BMJ. https://doi.org/10.1136/bmj.d124CrossRef

13.

Trenkwalder T, Rübsamen N, Schmitt VH et al (2019) Left ventricular geometry and function in early repolarization: results from the population-based Gutenberg Health Study. Clin Res Cardiol 108:1107–1116. https://doi.org/10.1007/s00392-019-01445-7CrossRefPubMed

14.

Vischer AS, Socrates T, Winterhalder C et al (2019) Impact of single-visit American versus European office blood pressure measurement procedure on individual blood pressure classification: a cross-sectional study. Clin Res Cardiol 108:990–999. https://doi.org/10.1007/s00392-019-01426-wCrossRefPubMed

15.

Panova-Noeva M, Neu MA, Eckerle S et al (2019) Cardiovascular risk factors are important determinants of platelet-dependent thrombin generation in adult survivors of childhood cancer. Clin Res Cardiol 108:438–447. https://doi.org/10.1007/s00392-018-1374-4CrossRefPubMed

16.

Llorens P, Javaloyes P, Martín-Sánchez FJ et al (2018) Time trends in characteristics, clinical course, and outcomes of 13,791 patients with acute heart failure. Clin Res Cardiol 107:897–913. https://doi.org/10.1007/s00392-018-1261-zCrossRefPubMed

17.

Kramm T, Wilkens H, Fuge J et al (2018) Incidence and characteristics of chronic thromboembolic pulmonary hypertension in Germany. Clin Res Cardiol 107:548–553. https://doi.org/10.1007/s00392-018-1215-5CrossRefPubMedPubMedCentral

18.

Miró Ò, Gil V, Xipell C et al (2017) IMPROV-ED study: outcomes after discharge for an episode of acute-decompensated heart failure and comparison between patients discharged from the emergency department and hospital wards. Clin Res Cardiol 106:369–378. https://doi.org/10.1007/s00392-016-1065-yCrossRefPubMed

19.

Groth KA, Stochholm K, Hove H et al (2017) Aortic events in a nationwide Marfan syndrome cohort. Clin Res Cardiol 106:105–112. https://doi.org/10.1007/s00392-016-1028-3CrossRefPubMed

20.

Gaede L, Aarberge L, Brandon Bravo Bruinsma G et al (2019) Correction to: Heart valve disease awareness survey 2017: what did we achieve since 2015? Clin Res Cardiol 108:116. https://doi.org/10.1007/s00392-018-1351-y(Clin Res Cardiol (2019) 108(1):61–67, 10.1007/s00392-018-1312-5)CrossRefPubMed

21.

Gaede L, Aarberge L, Brandon Bravo Bruinsma G et al (2019) Heart valve disease awareness survey 2017: what did we achieve since 2015? Clin Res Cardiol 108:61–67. https://doi.org/10.1007/s00392-018-1312-5CrossRefPubMed

22.

Bossard M, Thériault S, Aeschbacher S et al (2017) Factors independently associated with cardiac troponin I levels in young and healthy adults from the general population. Clin Res Cardiol 106:96–104. https://doi.org/10.1007/s00392-016-1026-5CrossRefPubMed

23.

Vongpatanasin W, Hillis D, Lange R (1996) Characteristics of prosthetic valves. N Engl J Med 335:407–416CrossRef

24.

Bloomfield P, Wheatley DJ, Prescott RJ, Miller HC (1991) Twelve-year comparison of a Bjork-Shiley mechanical heart valve with porcine bioprostheses. N Engl J Med 324:573–579. https://doi.org/10.1056/nejm199102283240901CrossRefPubMed

25.

Calderwood SB, Swincki LA, Waternaux CM, Karchmer AE, Buckley MJ (1985) Risk factors for the development of prosthetic valve endocarditis. Circulation 72:31–37. https://doi.org/10.1161/01.cir.72.1.31CrossRefPubMed

26.

Thuny F, Giorgi R, Habachi R et al (2012) Excess mortality and morbidity in patients surviving infective endocarditis. Am Heart J 164:94–101. https://doi.org/10.1016/j.ahj.2012.04.003CrossRefPubMed

27.

Martínez-Sellés M, Muñoz P, Estevez A et al (2008) Long-term outcome of infective endocarditis in non-intravenous drug users. Mayo Clin Proc 83:1213–1217. https://doi.org/10.4065/83.11.1213CrossRefPubMed

28.

Rostagno C, Carone E, Stefàno PL (2017) Role of mitral valve repair in active infective endocarditis: long term results. J Cardiothorac Surg 12:10–15. https://doi.org/10.1186/s13019-017-0604-6CrossRef

29.

Feringa HHH, Shaw LJ, Poldermans D et al (2007) Mitral valve repair and replacement in endocarditis: a systematic review of literature. Ann Thorac Surg 83:564–570. https://doi.org/10.1016/j.athoracsur.2006.09.023CrossRefPubMed

30.

Toyoda N, Itagaki S, Egorova NN et al (2017) Real-world outcomes of surgery for native mitral valve endocarditis. J Thorac Cardiovasc Surg 154:1906–1912.e9. https://doi.org/10.1016/j.jtcvs.2017.07.077CrossRefPubMed

31.

Mayer K, Aicher D, Feldner S et al (2012) Repair versus replacement of the aortic valve in active infective endocarditis. Eur J Cardio-Thoracic Surg 42:122–127. https://doi.org/10.1093/ejcts/ezr276CrossRef

32.

Gammie JS, O’Brien SM, Griffith BP, Peterson ED (2005) Surgical treatment of mitral valve endocarditis in North America. Ann Thorac Surg 80:2199–2204. https://doi.org/10.1016/j.athoracsur.2005.05.036CrossRefPubMed

33.

Chaudry MS, Carlson N, Gislason GH et al (2017) Risk of infective endocarditis in patients with end stage renal disease. Clin J Am Soc Nephrol 12:1814–1822. https://doi.org/10.2215/CJN.02320317CrossRefPubMedPubMedCentral

34.

Kurts C, Panzer U, Anders HJ, Rees AJ (2013) The immune system and kidney disease: basic concepts and clinical implications. Nat Rev Immunol 13:738–753. https://doi.org/10.1038/nri3523CrossRefPubMed

35.

James MT, Laupland KB, Tonelli M et al (2008) Risk of bloodstream infection in patients with chronic kidney disease not treated with dialysis. Arch Intern Med 168:2333–2339. https://doi.org/10.1001/archinte.168.21.2333CrossRefPubMed

36.

Toyoda N, Itagaki S, Tannous H et al (2018) Bioprosthetic versus mechanical valve replacement for infective endocarditis: focus on recurrence rates. Ann Thorac Surg. https://doi.org/10.1016/j.athoracsur.2017.12.046CrossRefPubMed

37.

Brennan JM, Edwards FH, Zhao Y et al (2013) Long-term safety and effectiveness of mechanical versus biologic aortic valve prostheses in older patients: results from the Society of Thoracic Surgeons Adult Cardiac Surgery National Database. Circulation 127:1647–1655. https://doi.org/10.1161/CIRCULATIONAHA.113.002003CrossRefPubMed

38.

Østergaard L, Valeur N, Ihlemann N et al (2018) Incidence and factors associated with infective endocarditis in patients undergoing left-sided heart valve replacement. Eur Heart J 39:2668–2675. https://doi.org/10.1093/eurheartj/ehy153CrossRefPubMed

39.

Sundbøll J, Adelborg K, Munch T et al (2016) Positive predictive value of cardiovascular diagnoses in the Danish National Patient Registry: a validation study. BMJ Open 6:e012832. https://doi.org/10.1136/bmjopen-2016-012832CrossRefPubMedPubMedCentral

Titel: Recurrent infective endocarditis versus first-time infective endocarditis after heart valve surgery
verfasst von: Eva Havers-Borgersen
Jawad H. Butt
Lauge Østergaard
Henning Bundgaard
Morten Smerup
Niels Eske Bruun
Gunnar H. Gislason
Christian Torp-Pedersen
Lars Køber
Emil L. Fosbøl
Publikationsdatum: 17.03.2020
Verlag: Springer Berlin Heidelberg
Erschienen in: Clinical Research in Cardiology / Ausgabe 11/2020
Print ISSN: 1861-0684
Elektronische ISSN: 1861-0692
DOI: https://doi.org/10.1007/s00392-020-01628-7

Neu im Fachgebiet Kardiologie

25.04.2024 | Hypotonie | Nachrichten

Update Kardiologie

Bestellen Sie unseren Fach-Newsletter und bleiben Sie gut informiert.

Newsletter bestellen

Springer Medizin

Recurrent infective endocarditis versus first-time infective endocarditis after heart valve surgery

Abstract

Objective

Methods

Results

Conclusions

Graphic abstract

Neu im Fachgebiet Kardiologie

Niedriger diastolischer Blutdruck erhöht Risiko für schwere kardiovaskuläre Komplikationen

Therapiestart mit Blutdrucksenkern erhöht Frakturrisiko

Adipositas-Medikament auch gegen Schlafapnoe wirksam

Komplette Revaskularisation bei Infarkt: Neue Studie setzt ein Fragezeichen

Update Kardiologie

Springer Medizin

Abstract

Objective

Methods

Results

Conclusions

Graphic abstract

Bitte loggen Sie sich ein, um Zugang zu diesem Inhalt zu erhalten

Weitere Artikel der Ausgabe 11/2020

Optimizing diastolic pressure gradient assessment

Successful endovascular treatment of multiple systemic aneurysms in a patient with vascular Ehlers–Danlos syndrome

Effect of concomitant antiplatelet agents on clinical outcomes in the edoxaban vs warfarin in subjects undergoing cardioversion of atrial fibrillation (ENSURE-AF) randomized trial

Renal AA amyloidosis leading to early diagnosis and treatment of takayasu arteritis: a case report and review of the literature

Covariate adjusted reanalysis of the I-Preserve trial

Impact of ultra-marathon and marathon on biomarkers of myocyte necrosis and cardiac congestion: a prospective observational study

Neu im Fachgebiet Kardiologie

Niedriger diastolischer Blutdruck erhöht Risiko für schwere kardiovaskuläre Komplikationen

Therapiestart mit Blutdrucksenkern erhöht Frakturrisiko

Adipositas-Medikament auch gegen Schlafapnoe wirksam

Komplette Revaskularisation bei Infarkt: Neue Studie setzt ein Fragezeichen

Update Kardiologie