Recurrent Oropharyngeal Squamous Cell Carcinomas Maintain Anti-tumor Immunity and Multinucleation Levels Following Completion of Radiation
- 23.11.2023
- Research
Erschienen in:
- Verfasst von
- Patricia Castro
- Germán Corredor
- Can Koyuncu
- Luke A. Nordstrom
- Michelle Tiji
- Taylor Leavitt
- James S. Lewis Jr.
- Anant Madabhushi
- Mitchell J. Frederick
- Vlad C. Sandulache
- Erschienen in
- Head and Neck Pathology | Ausgabe 4/2023
Abstract
Objective
Oropharyngeal squamous cell carcinoma (OPSCC) recurrence is almost universally fatal. Development of effective therapeutic options requires an improved understanding of recurrent OPSCC biology.
Methods
We analyzed paired primary-recurrent OPSCC from Veterans treated at the Michael E. DeBakey Veterans Affairs Medical Center between 2000 and 2020 who received curative intent radiation-based treatment (with or without chemotherapy). Patient tumors were analyzed using standard immunohistochemistry and automated imaging of infiltrating lymphocytes and multinucleated tumor cells coupled to machine learning algorithms.
Results
Primary and recurrent tumors demonstrated high concordance via p16 and p53 immunohistochemistry, with comparable levels of multinucleation. In contrast, recurrent tumors demonstrated significantly higher levels of CD8+ tumor infiltrating lymphocytes (p<0.05) and higher levels of PD-L1 expression (p<0.05).
Conclusion
Exposure to chemo-radiation and recurrence following treatment preserves critical features of intrinsic tumor biology and the tumor immune microenvironment suggesting that novel treatment regimens may be as effective in the salvage setting as in the definitive intent setting.
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- Titel
- Recurrent Oropharyngeal Squamous Cell Carcinomas Maintain Anti-tumor Immunity and Multinucleation Levels Following Completion of Radiation
- Verfasst von
-
Patricia Castro
Germán Corredor
Can Koyuncu
Luke A. Nordstrom
Michelle Tiji
Taylor Leavitt
James S. Lewis Jr.
Anant Madabhushi
Mitchell J. Frederick
Vlad C. Sandulache
- Publikationsdatum
- 23.11.2023
- Verlag
- Springer US
- Erschienen in
-
Head and Neck Pathology / Ausgabe 4/2023
Elektronische ISSN: 1936-0568 - DOI
- https://doi.org/10.1007/s12105-023-01597-z
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