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Erschienen in: Current Diabetes Reports 11/2018

01.11.2018 | Lifestyle Management to Reduce Diabetes/Cardiovascular Risk (B Conway and H Keenan, Section Editors)

Red Meat Consumption (Heme Iron Intake) and Risk for Diabetes and Comorbidities?

verfasst von: Ranjita Misra, Padmini Balagopal, Sudha Raj, Thakor G. Patel

Erschienen in: Current Diabetes Reports | Ausgabe 11/2018

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Abstract

Purpose of Review

To examine the role of red meat consumption, especially heme iron intake, and risk for diabetes and its comorbidities.

Recent Findings

Studies consistently show that consumption of red meat has been contributory to a multitude of chronic conditions such as diabetes, CVD, and malignancies. There are various emerging reasons that strengthen this link—from the basic constituents of red meat like the heme iron component, the metabolic reactions that take place after consumption, and finally to the methods used to cook it. The causative links show that even occasional use raises the risk of T2DM.

Summary

Prior studies show how nitrites and nitrates in red meat can lead to increased insulin resistance, dysregulated blood glucose levels, and elevated oxidative stress all leading to chronic diseases. With the rise in these preventable chronic diseases, we examine how disease-causing links can be eliminated with appropriate lifestyle choices.
Literatur
1.
Zurück zum Zitat •• Talaei M, Wang YL, Yuan JM, Pan A, Koh WP. Meat, dietary heme iron, and risk of type 2 diabetes mellitus: The Singapore Chinese Health Study. Am J Epidemiol. 2017;186(7):824–33. This study provides a thorough description of how red meat and heme iron intake were associated with higher risk of type 2 diabetes mellitus. CrossRef •• Talaei M, Wang YL, Yuan JM, Pan A, Koh WP. Meat, dietary heme iron, and risk of type 2 diabetes mellitus: The Singapore Chinese Health Study. Am J Epidemiol. 2017;186(7):824–33. This study provides a thorough description of how red meat and heme iron intake were associated with higher risk of type 2 diabetes mellitus. CrossRef
2.
Zurück zum Zitat Mari-Sanchis A, Gea A, Basterra-Gortari FJ, Martinez-Gonzalez MA, Beunza JJ, Bes-Rastrollo M. Meat consumption and risk of developing type 2 diabetes in the SUN project: a highly educated middle-class population. PLoS One. 2016;11(7):e0157990.CrossRef Mari-Sanchis A, Gea A, Basterra-Gortari FJ, Martinez-Gonzalez MA, Beunza JJ, Bes-Rastrollo M. Meat consumption and risk of developing type 2 diabetes in the SUN project: a highly educated middle-class population. PLoS One. 2016;11(7):e0157990.CrossRef
3.
Zurück zum Zitat Pan A, Sun Q, Bernstein AM, Schulze MB, Manson JE, Stampfer MJ, et al. Red meat consumption and mortality: results from 2 prospective cohort studies. Arch Intern Med. 2012;172(7):555–63.CrossRef Pan A, Sun Q, Bernstein AM, Schulze MB, Manson JE, Stampfer MJ, et al. Red meat consumption and mortality: results from 2 prospective cohort studies. Arch Intern Med. 2012;172(7):555–63.CrossRef
4.
Zurück zum Zitat Pan A, Sun Q, Bernstein AM, Schulze MB, Manson JE, Willett WC, et al. Red meat consumption and risk of type 2 diabetes: 3 cohorts of US adults and an updated meta-analysis. Am J Clin Nutr. 2011;94(4):1088–96.CrossRef Pan A, Sun Q, Bernstein AM, Schulze MB, Manson JE, Willett WC, et al. Red meat consumption and risk of type 2 diabetes: 3 cohorts of US adults and an updated meta-analysis. Am J Clin Nutr. 2011;94(4):1088–96.CrossRef
5.
Zurück zum Zitat Schulze MB, Manson JE, Willett WC, Hu FB. Processed meat intake and incidence of type 2 diabetes in younger and middle-aged women. Diabetologia. 2003;46(11):1465–73.CrossRef Schulze MB, Manson JE, Willett WC, Hu FB. Processed meat intake and incidence of type 2 diabetes in younger and middle-aged women. Diabetologia. 2003;46(11):1465–73.CrossRef
6.
Zurück zum Zitat van Dam RM, Willett WC, Rimm EB, Stampfer MJ, Hu FB. Dietary fat and meat intake in relation to risk of type 2 diabetes in men. Diabetes Care. 2002;25(3):417–24.CrossRef van Dam RM, Willett WC, Rimm EB, Stampfer MJ, Hu FB. Dietary fat and meat intake in relation to risk of type 2 diabetes in men. Diabetes Care. 2002;25(3):417–24.CrossRef
7.
Zurück zum Zitat Wyness L. The role of red meat in the diet: nutrition and health benefits. Proc Nutr Soc. 2016;75(3):227–32.CrossRef Wyness L. The role of red meat in the diet: nutrition and health benefits. Proc Nutr Soc. 2016;75(3):227–32.CrossRef
8.
Zurück zum Zitat Binnie MA, Barlow K, Johnson V, Harrison C. Red meats: time for a paradigm shift in dietary advice. Meat Sci. 2014;98(3):445–51.CrossRef Binnie MA, Barlow K, Johnson V, Harrison C. Red meats: time for a paradigm shift in dietary advice. Meat Sci. 2014;98(3):445–51.CrossRef
9.
Zurück zum Zitat Bouvard V, Loomis D, Guyton KZ, Grosse Y, Ghissassi FE, Benbrahim-Tallaa L, et al. International Agency for Research on Cancer Monograph Working G: carcinogenicity of consumption of red and processed meat. Lancet Oncol. 2015;16(16):1599–600.CrossRef Bouvard V, Loomis D, Guyton KZ, Grosse Y, Ghissassi FE, Benbrahim-Tallaa L, et al. International Agency for Research on Cancer Monograph Working G: carcinogenicity of consumption of red and processed meat. Lancet Oncol. 2015;16(16):1599–600.CrossRef
10.
Zurück zum Zitat Tasevska N, Sinha R, Kipnis V, Subar AF, Leitzmann MF, Hollenbeck AR, et al. A prospective study of meat, cooking methods, meat mutagens, heme iron, and lung cancer risks. Am J Clin Nutr. 2009;89(6):1884–94.CrossRef Tasevska N, Sinha R, Kipnis V, Subar AF, Leitzmann MF, Hollenbeck AR, et al. A prospective study of meat, cooking methods, meat mutagens, heme iron, and lung cancer risks. Am J Clin Nutr. 2009;89(6):1884–94.CrossRef
11.
Zurück zum Zitat Santarelli RL, Pierre F, Corpet DE. Processed meat and colorectal cancer: a review of epidemiologic and experimental evidence. Nutr Cancer. 2008;60(2):131–44.CrossRef Santarelli RL, Pierre F, Corpet DE. Processed meat and colorectal cancer: a review of epidemiologic and experimental evidence. Nutr Cancer. 2008;60(2):131–44.CrossRef
12.
Zurück zum Zitat Zhou D, Xi B, Zhao M, Wang L, Veeranki SP. Uncontrolled hypertension increases risk of all-cause and cardiovascular disease mortality in US adults: the NHANES III Linked Mortality Study. Sci Rep. 2018;8(1):9418.CrossRef Zhou D, Xi B, Zhao M, Wang L, Veeranki SP. Uncontrolled hypertension increases risk of all-cause and cardiovascular disease mortality in US adults: the NHANES III Linked Mortality Study. Sci Rep. 2018;8(1):9418.CrossRef
13.
Zurück zum Zitat Wolk A. Potential health hazards of eating red meat. J Intern Med. 2017;281(2):106–22.CrossRef Wolk A. Potential health hazards of eating red meat. J Intern Med. 2017;281(2):106–22.CrossRef
14.
Zurück zum Zitat •• Swaminathan S, Fonseca VA, Alam MG, Shah SV. The role of iron in diabetes and its complications. Diabetes Care. 2007;30(7):1926–33. This review article provides an in-depth discussion on how elevated body iron stores play a role in the pathophysiology of type 2 diabetes and its complications, particularly diabetic nephropathy and cardiovascular disease (CVD). CrossRef •• Swaminathan S, Fonseca VA, Alam MG, Shah SV. The role of iron in diabetes and its complications. Diabetes Care. 2007;30(7):1926–33. This review article provides an in-depth discussion on how elevated body iron stores play a role in the pathophysiology of type 2 diabetes and its complications, particularly diabetic nephropathy and cardiovascular disease (CVD). CrossRef
15.
Zurück zum Zitat White DL, Collinson A. Red meat, dietary heme iron, and risk of type 2 diabetes: the involvement of advanced lipoxidation endproducts. Adv Nutr. 2013;4(4):403–11.CrossRef White DL, Collinson A. Red meat, dietary heme iron, and risk of type 2 diabetes: the involvement of advanced lipoxidation endproducts. Adv Nutr. 2013;4(4):403–11.CrossRef
16.
Zurück zum Zitat Fernandez-Real JM, Lopez-Bermejo A, Ricart W. Cross-talk between iron metabolism and diabetes. Diabetes. 2002;51(8):2348–54.CrossRef Fernandez-Real JM, Lopez-Bermejo A, Ricart W. Cross-talk between iron metabolism and diabetes. Diabetes. 2002;51(8):2348–54.CrossRef
17.
Zurück zum Zitat Battaglia Richi E, Baumer B, Conrad B, Darioli R, Schmid A, Keller U. Health risks associated with meat consumption: a review of epidemiological studies. Int J Vitam Nutr Res. 2015;85(1–2):70–8.CrossRef Battaglia Richi E, Baumer B, Conrad B, Darioli R, Schmid A, Keller U. Health risks associated with meat consumption: a review of epidemiological studies. Int J Vitam Nutr Res. 2015;85(1–2):70–8.CrossRef
18.
Zurück zum Zitat Pan A, Sun Q, Bernstein AM, Manson JE, Willett WC, Hu FB. Changes in red meat consumption and subsequent risk of type 2 diabetes mellitus: three cohorts of US men and women. JAMA Intern Med. 2013;173(14):1328–35.CrossRef Pan A, Sun Q, Bernstein AM, Manson JE, Willett WC, Hu FB. Changes in red meat consumption and subsequent risk of type 2 diabetes mellitus: three cohorts of US men and women. JAMA Intern Med. 2013;173(14):1328–35.CrossRef
19.
Zurück zum Zitat de la Monte SM, Tong M, Lawton M, Longato L. Nitrosamine exposure exacerbates high fat diet-mediated type 2 diabetes mellitus, non-alcoholic steatohepatitis, and neurodegeneration with cognitive impairment. Mol Neurodegener. 2009;4:54.CrossRef de la Monte SM, Tong M, Lawton M, Longato L. Nitrosamine exposure exacerbates high fat diet-mediated type 2 diabetes mellitus, non-alcoholic steatohepatitis, and neurodegeneration with cognitive impairment. Mol Neurodegener. 2009;4:54.CrossRef
20.
Zurück zum Zitat Powell LW, Seckington RC, Deugnier Y. Haemochromatosis. Lancet. 2016;388(10045):706–16.CrossRef Powell LW, Seckington RC, Deugnier Y. Haemochromatosis. Lancet. 2016;388(10045):706–16.CrossRef
21.
Zurück zum Zitat Egger G, Dixon J. Beyond obesity and lifestyle: a review of 21st century chronic disease determinants. Biomed Res Int. 2014;2014:731685.CrossRef Egger G, Dixon J. Beyond obesity and lifestyle: a review of 21st century chronic disease determinants. Biomed Res Int. 2014;2014:731685.CrossRef
22.
Zurück zum Zitat • Halliwell B, Gutteridge JM. Role of free radicals and catalytic metal ions in human disease: an overview. Methods Enzymol. 1990;186:1–85. This review article provides a detailed description of the role of free radicals and catalytic metal ions in human disease. CrossRef • Halliwell B, Gutteridge JM. Role of free radicals and catalytic metal ions in human disease: an overview. Methods Enzymol. 1990;186:1–85. This review article provides a detailed description of the role of free radicals and catalytic metal ions in human disease. CrossRef
23.
Zurück zum Zitat El-Bab MF, Zaki NS, Mojaddidi MA, Al-Barry M, El-Beshbishy HA. Diabetic retinopathy is associated with oxidative stress and mitigation of gene expression of antioxidant enzymes. Int J Gen Med. 2013;6:799–806.CrossRef El-Bab MF, Zaki NS, Mojaddidi MA, Al-Barry M, El-Beshbishy HA. Diabetic retinopathy is associated with oxidative stress and mitigation of gene expression of antioxidant enzymes. Int J Gen Med. 2013;6:799–806.CrossRef
24.
Zurück zum Zitat Gorin Y, Block K. Nox as a target for diabetic complications. Clin Sci (Lond). 2013;125(8):361–82.CrossRef Gorin Y, Block K. Nox as a target for diabetic complications. Clin Sci (Lond). 2013;125(8):361–82.CrossRef
25.
Zurück zum Zitat Headland SE, Norling LV. The resolution of inflammation: principles and challenges. Semin Immunol. 2015;27(3):149–60.CrossRef Headland SE, Norling LV. The resolution of inflammation: principles and challenges. Semin Immunol. 2015;27(3):149–60.CrossRef
26.
Zurück zum Zitat Matzinger M, Fischhuber K, Heiss EH. Activation of Nrf2 signaling by natural products—can it alleviate diabetes? Biotechnol Adv. 2018;36(6):1738–67.CrossRef Matzinger M, Fischhuber K, Heiss EH. Activation of Nrf2 signaling by natural products—can it alleviate diabetes? Biotechnol Adv. 2018;36(6):1738–67.CrossRef
27.
Zurück zum Zitat • Schwingshackl L, Hoffmann G, Lampousi AM, Knuppel S, Iqbal K, Schwedhelm C, et al. Food groups and risk of type 2 diabetes mellitus: a systematic review and meta-analysis of prospective studies. Eur J Epidemiol. 2017;32(5):363–75. This systematic review and meta-analysis provided comprehensive knowledge regarding the association between whole grains, refined grains, vegetables, fruits, nuts, legumes, eggs, dairy, fish, red meat, processed meat, and sugar-sweetened beverages intake and risk of type 2 diabetes. CrossRef • Schwingshackl L, Hoffmann G, Lampousi AM, Knuppel S, Iqbal K, Schwedhelm C, et al. Food groups and risk of type 2 diabetes mellitus: a systematic review and meta-analysis of prospective studies. Eur J Epidemiol. 2017;32(5):363–75. This systematic review and meta-analysis provided comprehensive knowledge regarding the association between whole grains, refined grains, vegetables, fruits, nuts, legumes, eggs, dairy, fish, red meat, processed meat, and sugar-sweetened beverages intake and risk of type 2 diabetes. CrossRef
28.
Zurück zum Zitat Kataria Y, Wu Y, Horskjaer PH, Mandrup-Poulsen T, Ellervik C. Iron status and gestational diabetes—a meta-analysis. Nutrients. 2018;10(5)CrossRef Kataria Y, Wu Y, Horskjaer PH, Mandrup-Poulsen T, Ellervik C. Iron status and gestational diabetes—a meta-analysis. Nutrients. 2018;10(5)CrossRef
29.
Zurück zum Zitat Andrews NC. The iron transporter DMT1. Int J Biochem Cell Biol. 1999;31(10):991–4.CrossRef Andrews NC. The iron transporter DMT1. Int J Biochem Cell Biol. 1999;31(10):991–4.CrossRef
30.
Zurück zum Zitat Miyajima H. Aceruloplasminemia, an iron metabolic disorder. Neuropathology. 2003;23(4):345–50.CrossRef Miyajima H. Aceruloplasminemia, an iron metabolic disorder. Neuropathology. 2003;23(4):345–50.CrossRef
31.
Zurück zum Zitat Adams PC, Reboussin DM, Barton JC, McLaren CE, Eckfeldt JH, McLaren GD, et al. Hemochromatosis and iron-overload screening in a racially diverse population. N Engl J Med. 2005;352(17):1769–78.CrossRef Adams PC, Reboussin DM, Barton JC, McLaren CE, Eckfeldt JH, McLaren GD, et al. Hemochromatosis and iron-overload screening in a racially diverse population. N Engl J Med. 2005;352(17):1769–78.CrossRef
32.
Zurück zum Zitat Shah SV, Fonseca VA. Iron and diabetes revisited. Diabetes Care. 2011;34(7):1676–7.CrossRef Shah SV, Fonseca VA. Iron and diabetes revisited. Diabetes Care. 2011;34(7):1676–7.CrossRef
33.
Zurück zum Zitat Reif DW. Ferritin as a source of iron for oxidative damage. Free Radic Biol Med. 1992;12(5):417–27.CrossRef Reif DW. Ferritin as a source of iron for oxidative damage. Free Radic Biol Med. 1992;12(5):417–27.CrossRef
34.
Zurück zum Zitat Tiedge M, Lortz S, Drinkgern J, Lenzen S. Relation between antioxidant enzyme gene expression and antioxidative defense status of insulin-producing cells. Diabetes. 1997;46(11):1733–42.CrossRef Tiedge M, Lortz S, Drinkgern J, Lenzen S. Relation between antioxidant enzyme gene expression and antioxidative defense status of insulin-producing cells. Diabetes. 1997;46(11):1733–42.CrossRef
35.
Zurück zum Zitat Masquio DC, de Piano A, Campos RM, Sanches PL, Corgosinho FC, Carnier J, et al. Saturated fatty acid intake can influence increase in plasminogen activator inhibitor-1 in obese adolescents. Horm Metab Res. 2014;46(4):245–51.CrossRef Masquio DC, de Piano A, Campos RM, Sanches PL, Corgosinho FC, Carnier J, et al. Saturated fatty acid intake can influence increase in plasminogen activator inhibitor-1 in obese adolescents. Horm Metab Res. 2014;46(4):245–51.CrossRef
36.
Zurück zum Zitat Lynch CJ, Adams SH. Branched-chain amino acids in metabolic signalling and insulin resistance. Nat Rev Endocrinol. 2014;10(12):723–36.CrossRef Lynch CJ, Adams SH. Branched-chain amino acids in metabolic signalling and insulin resistance. Nat Rev Endocrinol. 2014;10(12):723–36.CrossRef
37.
Zurück zum Zitat Yamagishi S, Nakamura N, Suematsu M, Kaseda K, Matsui T. Advanced glycation end products: a molecular target for vascular complications in diabetes. Mol Med. 2015;21(Suppl 1):S32–40.CrossRef Yamagishi S, Nakamura N, Suematsu M, Kaseda K, Matsui T. Advanced glycation end products: a molecular target for vascular complications in diabetes. Mol Med. 2015;21(Suppl 1):S32–40.CrossRef
38.
Zurück zum Zitat Rhee SY, Kim YS. The role of advanced glycation end products in diabetic vascular complications. Diabetes Metab J. 2018;42(3):188–95.CrossRef Rhee SY, Kim YS. The role of advanced glycation end products in diabetic vascular complications. Diabetes Metab J. 2018;42(3):188–95.CrossRef
39.
Zurück zum Zitat Kim Y, Keogh J, Clifton P. A review of potential metabolic etiologies of the observed association between red meat consumption and development of type 2 diabetes mellitus. Metabolism. 2015;64(7):768–79.CrossRef Kim Y, Keogh J, Clifton P. A review of potential metabolic etiologies of the observed association between red meat consumption and development of type 2 diabetes mellitus. Metabolism. 2015;64(7):768–79.CrossRef
40.
Zurück zum Zitat Kellow NJ, Savige GS. Dietary advanced glycation end-product restriction for the attenuation of insulin resistance, oxidative stress and endothelial dysfunction: a systematic review. Eur J Clin Nutr. 2013;67(3):239–48.CrossRef Kellow NJ, Savige GS. Dietary advanced glycation end-product restriction for the attenuation of insulin resistance, oxidative stress and endothelial dysfunction: a systematic review. Eur J Clin Nutr. 2013;67(3):239–48.CrossRef
41.
Zurück zum Zitat Uribarri J, Cai W, Sandu O, Peppa M, Goldberg T, Vlassara H. Diet-derived advanced glycation end products are major contributors to the body’s AGE pool and induce inflammation in healthy subjects. Ann N Y Acad Sci. 2005;1043:461–6.CrossRef Uribarri J, Cai W, Sandu O, Peppa M, Goldberg T, Vlassara H. Diet-derived advanced glycation end products are major contributors to the body’s AGE pool and induce inflammation in healthy subjects. Ann N Y Acad Sci. 2005;1043:461–6.CrossRef
42.
Zurück zum Zitat Stirban A, Gawlowski T, Roden M. Vascular effects of advanced glycation endproducts: clinical effects and molecular mechanisms. Mol Metab. 2014;3(2):94–108.CrossRef Stirban A, Gawlowski T, Roden M. Vascular effects of advanced glycation endproducts: clinical effects and molecular mechanisms. Mol Metab. 2014;3(2):94–108.CrossRef
43.
Zurück zum Zitat Minich DM, Bland JS. Personalized lifestyle medicine: relevance for nutrition and lifestyle recommendations. ScientificWorldJournal. 2013;2013:129841.CrossRef Minich DM, Bland JS. Personalized lifestyle medicine: relevance for nutrition and lifestyle recommendations. ScientificWorldJournal. 2013;2013:129841.CrossRef
44.
Zurück zum Zitat •• Grosso G, Micek A, Godos J, Pajak A, Sciacca S, Galvano F, et al. Health risk factors associated with meat, fruit and vegetable consumption in cohort studies: a comprehensive meta-analysis. PLoS One. 2017;12(8):e0183787. This systematic review provides a comprehensive description of factors associated with red, processed, and total meat consumption and selected health risk factors such as body weight status, smoking habit, physical activity level, level of education, and alcohol drinking among individuals. CrossRef •• Grosso G, Micek A, Godos J, Pajak A, Sciacca S, Galvano F, et al. Health risk factors associated with meat, fruit and vegetable consumption in cohort studies: a comprehensive meta-analysis. PLoS One. 2017;12(8):e0183787. This systematic review provides a comprehensive description of factors associated with red, processed, and total meat consumption and selected health risk factors such as body weight status, smoking habit, physical activity level, level of education, and alcohol drinking among individuals. CrossRef
45.
Zurück zum Zitat Petersen KS, Flock MR, Richter CK, Mukherjea R, Slavin JL, Kris-Etherton PM. Healthy dietary patterns for preventing cardiometabolic disease: the role of plant-based foods and animal products. Curr Dev Nutr. 2017;1(12)CrossRef Petersen KS, Flock MR, Richter CK, Mukherjea R, Slavin JL, Kris-Etherton PM. Healthy dietary patterns for preventing cardiometabolic disease: the role of plant-based foods and animal products. Curr Dev Nutr. 2017;1(12)CrossRef
Metadaten
Titel
Red Meat Consumption (Heme Iron Intake) and Risk for Diabetes and Comorbidities?
verfasst von
Ranjita Misra
Padmini Balagopal
Sudha Raj
Thakor G. Patel
Publikationsdatum
01.11.2018
Verlag
Springer US
Erschienen in
Current Diabetes Reports / Ausgabe 11/2018
Print ISSN: 1534-4827
Elektronische ISSN: 1539-0829
DOI
https://doi.org/10.1007/s11892-018-1071-8

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