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Journal of Mammary Gland Biology and Neoplasia

15.11.2019

Redirecting Normal and Cancer Stem Cells to a Mammary Epithelial Cell Fate

verfasst von: Anastasia Frank-Kamenetskii, Brian W. Booth

Erschienen in: Journal of Mammary Gland Biology and Neoplasia

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Abstract

Tissue microenvironments, also known as stem cell niches, influence not only resident cells but also cells in surrounding tissues. Physical and biochemical intercellular signals originating from resident stem cells or non-stem cells participate in the homeostasis of the tissue regulating cell proliferation, differentiation, wound healing, tissue remodeling, and tumorigenesis. In recent publications it has been demonstrated that the normal mouse mammary microenvironment can provide development and differentiation guidance to not only resident mammary cells but also cells of non-mammary origin including tumor-derived cells. When placed in reforming mammary stem cell niches the non-mammary cells proliferate and differentiate along mammary epithelial cell lineages and contribute progeny to reforming mammary gland outgrowths. The tumor-derived cells that are redirected to assume mammary epithelial phenotypes lose their cancer-forming capacity and shift their gene expression profiles from a cancer profile towards a normal mammary epithelial expression profile. This review summarizes the recent discoveries regarding the ability of the normal mouse mammary microenvironment to dictate the cell fates of non-mammary cells introduced into mammary stem cell niches.

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Titel: Redirecting Normal and Cancer Stem Cells to a Mammary Epithelial Cell Fate
verfasst von: Anastasia Frank-Kamenetskii
Brian W. Booth
Publikationsdatum: 15.11.2019
Verlag: Springer US
Erschienen in: Journal of Mammary Gland Biology and Neoplasia
Print ISSN: 1083-3021
Elektronische ISSN: 1573-7039
DOI: https://doi.org/10.1007/s10911-019-09439-x

Neu im Fachgebiet Onkologie

25.04.2024 | Nierenkarzinom | Nachrichten

Springer Medizin

Redirecting Normal and Cancer Stem Cells to a Mammary Epithelial Cell Fate

Abstract

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Springer Medizin

Abstract

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Neu im Fachgebiet Onkologie

Adjuvante Immuntherapie verlängert Leben bei RCC

Alectinib verbessert krankheitsfreies Überleben bei ALK-positivem NSCLC

Bei Senioren mit Prostatakarzinom auf Anämie achten!

ICI-Therapie in der Schwangerschaft wird gut toleriert

Update Onkologie