Erschienen in:
04.07.2019 | Retinal Disorders
Reduced baseline diameter and contraction of peripheral retinal arterioles immediately after remote ischemia in diabetic patients
verfasst von:
Yasmin El Dabagh, Line Petersen, Michael Pedersen, Toke Bek
Erschienen in:
Graefe's Archive for Clinical and Experimental Ophthalmology
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Ausgabe 10/2019
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Abstract
Purpose
Remote ischemic conditioning (RIC) implies that transient ischemia in one organ can affect blood flow and protect from ischemia in another remote organ such as the retina. The purpose of the present study was to investigate the effect of RIC on the diameter of retinal arterioles in patients with diabetic retinopathy and whether this effect differs among peripheral and macular vessels.
Methods
In twenty type 1 diabetes patients aged 20–31 years, the Dynamic Vessel Analyzer (DVA) was used to measure diameters of peripheral and macular arterioles during rest, isometric exercise, and flicker stimulation. Measurements were obtained before, immediately after, and 1 h after RIC, and were compared to responses obtained from normal persons.
Results
The reduced baseline diameter (p < 0.009) and contraction of peripheral retinal arterioles during isometric exercise (p = 0.025) observed immediately after RIC in normal persons were absent in the studied diabetic patients.
Conclusions
RIC affects the diameter of peripheral but not macular arterioles in normal persons, but the response is abolished in diabetic patients.
Trial registration
NCT03906383