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Erschienen in: Graefe's Archive for Clinical and Experimental Ophthalmology 10/2019

04.07.2019 | Retinal Disorders

Reduced baseline diameter and contraction of peripheral retinal arterioles immediately after remote ischemia in diabetic patients

verfasst von: Yasmin El Dabagh, Line Petersen, Michael Pedersen, Toke Bek

Erschienen in: Graefe's Archive for Clinical and Experimental Ophthalmology | Ausgabe 10/2019

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Abstract

Purpose

Remote ischemic conditioning (RIC) implies that transient ischemia in one organ can affect blood flow and protect from ischemia in another remote organ such as the retina. The purpose of the present study was to investigate the effect of RIC on the diameter of retinal arterioles in patients with diabetic retinopathy and whether this effect differs among peripheral and macular vessels.

Methods

In twenty type 1 diabetes patients aged 20–31 years, the Dynamic Vessel Analyzer (DVA) was used to measure diameters of peripheral and macular arterioles during rest, isometric exercise, and flicker stimulation. Measurements were obtained before, immediately after, and 1 h after RIC, and were compared to responses obtained from normal persons.

Results

The reduced baseline diameter (p < 0.009) and contraction of peripheral retinal arterioles during isometric exercise (p = 0.025) observed immediately after RIC in normal persons were absent in the studied diabetic patients.

Conclusions

RIC affects the diameter of peripheral but not macular arterioles in normal persons, but the response is abolished in diabetic patients.

Trial registration

NCT03906383
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Metadaten
Titel
Reduced baseline diameter and contraction of peripheral retinal arterioles immediately after remote ischemia in diabetic patients
verfasst von
Yasmin El Dabagh
Line Petersen
Michael Pedersen
Toke Bek
Publikationsdatum
04.07.2019
Verlag
Springer Berlin Heidelberg
Erschienen in
Graefe's Archive for Clinical and Experimental Ophthalmology / Ausgabe 10/2019
Print ISSN: 0721-832X
Elektronische ISSN: 1435-702X
DOI
https://doi.org/10.1007/s00417-019-04407-x

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