The authors declare that they have no competing interest.
MCH, WCT, and TTO contributed to researched materials and analysis tools. CCW and WYS contributed to data analysis. JHY, SJC, and CCT contributed to experiments designs, data analysis, and wrote the manuscript. All authors provided comments on the drafts and have read and approved the final version.
To date, there has been no studies to evaluate the incidence of Crohn’s disease in systemic sclerosis patients. The goals of this study were to evaluate the incidence of Crohn’s disease and its relationship with sex and age in patients with systemic sclerosis.
We enrolled patients with systemic sclerosis and controls from Taiwan’s Registry of Catastrophic Illness Database and National Health Insurance Research Database. Every systemic sclerosis patient was matched to at most three controls by sex, age, month and year of initial diagnosis of systemic sclerosis. The standardized incidence ratio (SIR) of Crohn’s disease in systemic sclerosis patients, and 95 % confidence interval (95 % CI) were calculated. Cox hazard regression was used to calculate the hazard ratio (HR).
The study enrolled 2,829 patients with systemic sclerosis and 8,257 controls. Male and female patients with systemic sclerosis both had lower rates of incident Crohn’s disease (SIR: 0.18, 95 % CI = 0.05–0.62; SIR: 0.10, 95 % CI = 0.05–0.21, respectively). The risk of incident Crohn’s disease in systemic sclerosis was still lower than in controls when we stratified the patients according to their ages. In Cox hazard regression, the hazard rates of Crohn’s disease were lower in systemic sclerosis patients after adjusting for genders and ages (HR: 0.12, 95 % CI = 0.06–0.21, p < 0.001).
Systemic sclerosis is associated with decreased incidence of, irrespective of sex and age of the patients.
Koumakis E, Dieudé P, Avouac J, Kahan A, Allanore Y. Association des Sclérodermiques de France. Familial autoimmunity in systemic sclerosis- Results of a French-based case-control family study. J Rheumatol. 2012;39:532–8.
Robinson Jr D, Eisenberg D, Nietert PJ, Doyle M, Bala M, Paramore C. Systemic sclerosis prevalence and comorbidities in the US, 2001–2002. Curr Med Res Opin. 2008;24:1157–66.
Bureau of National Health Insurance. Universal Health Coverage in Taiwan. 2012. http://www.nhi.gov.tw/Resource/webdata/21717_1_20120808UniversalHealthCoverage.pdf. Accessed 26 June 2015.
Kuo CF, Grainge MJ, Valdes AM, See LC, Luo SF, Yu KH, et al. Familial risk of Sjögren’s syndrome and co-aggregation of autoimmune diseases in affected families: A nationwide population study. Arthritis Rheumatol. 2015. doi: 10.1002/art.39127.
Greenland S, Rothman KJ. Introduction to Stratified Analysis. In: Rothman KJ, Greenland S, Lash TL, editors. Modern Epidemiology, third ed. Philadelphia: Lippincott Williams & Wilkins; 2008: p. 252-282
Venneker GT, van den Hoogen FH, van Meegen M, de Kok-Nazaruk M, Hulsmans RF, Boerbooms AM, et al. Molecular heterogeneity of second and fourth components of complement and their genes in systemic sclerosis and association of HLA alleles A1, B8 and DR3 with limited and DR5 with diffuse systemic sclerosis. Exp Clin Immunogenet. 1998;15:90–9. CrossRefPubMed
Beretta L, Rueda B, Marchini M, Santaniello A, Simeón CP, Fonollosa V, et al. Analysis of class II human leucocyte antigens in Italian and Spanish systemic sclerosis. Rheumatology (Oxford). 2012;51:52–9. CrossRef
- Reduced incidence of Crohn’s disease in systemic sclerosis: a nationwide population study
- BioMed Central
Neu im Fachgebiet Orthopädie und Unfallchirurgie
Mail Icon II