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Erschienen in: Breast Cancer Research 1/2010

01.05.2010 | Poster presentation

Reduced MCPH1 expression in breast cancer and response to chemotherapy

verfasst von: J Richardson, A Shaaban, M Kamal, I Ellis, V Speirs, A Green, SM Bell

Erschienen in: Breast Cancer Research | Sonderheft 1/2010

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Excerpt

Previously we identified MCPH1, a DNA damage response protein involved in the regulation of BRCA1 and BRCA2, as the defective protein in one form of microcephaly. BRCA1 mutations are associated with basal-like breast cancer, which are often also negative for oestrogen receptor (ER), progesterone receptor (PR) and HER2. Our data indicate that MCPH1 plays a role in response to chemotherapeutic agents used in the treatment of breast cancer due to its role in DNA repair and the spindle checkpoint. …
Metadaten
Titel
Reduced MCPH1 expression in breast cancer and response to chemotherapy
verfasst von
J Richardson
A Shaaban
M Kamal
I Ellis
V Speirs
A Green
SM Bell
Publikationsdatum
01.05.2010
Verlag
BioMed Central
Erschienen in
Breast Cancer Research / Ausgabe Sonderheft 1/2010
Elektronische ISSN: 1465-542X
DOI
https://doi.org/10.1186/bcr2538

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