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Erschienen in: Endocrine 3/2017

25.01.2017 | Viewpoint

Reducing the prevalence of dysglycemia: is the time ripe to test the effectiveness of intervention in high-risk individuals with elevated 1 h post-load glucose levels?

verfasst von: Michael Bergman, Ram Jagannathan, Martin Buysschaert, Jose Luis Medina, Mary Ann Sevick, Karin Katz, Brenda Dorcely, Jesse Roth, Angela Chetrit, Rachel Dankner

Erschienen in: Endocrine | Ausgabe 3/2017

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Abstract

Identifying the earliest time point on the prediabetic continuum is critical to avoid progressive deterioration in β-cell function. Progressively rising glucose levels even within the “normal range” occur considerably late in the evolution to diabetes thus presenting an important opportunity for earlier diagnosis, treatment, and possible reversal. An elevated 1 h postprandial glucose level, not detected by current diagnostic standards, may provide an opportunity for the early identification of those at risk. When the 1 h post-load glucose level is elevated, lifestyle intervention may have the greatest benefit for preserving β-cell function and prevent further progression to prediabetes and diabetes. In view of the considerable consistent epidemiologic data in large disparate populations supporting the predictive capacity of the1 h post-load value for predicting progression to diabetes and mortality, the time is therefore ripe to evaluate this hypothesis in a large, prospective multicenter randomized trial with lifestyle intervention.
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Metadaten
Titel
Reducing the prevalence of dysglycemia: is the time ripe to test the effectiveness of intervention in high-risk individuals with elevated 1 h post-load glucose levels?
verfasst von
Michael Bergman
Ram Jagannathan
Martin Buysschaert
Jose Luis Medina
Mary Ann Sevick
Karin Katz
Brenda Dorcely
Jesse Roth
Angela Chetrit
Rachel Dankner
Publikationsdatum
25.01.2017
Verlag
Springer US
Erschienen in
Endocrine / Ausgabe 3/2017
Print ISSN: 1355-008X
Elektronische ISSN: 1559-0100
DOI
https://doi.org/10.1007/s12020-017-1236-2

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