Reference microarchitectural values measured by HR-pQCT in a Franco-Swiss cohort of young adult women
- 12.10.2021
- Original Article
Erschienen in:
- Verfasst von
- E. How Shing Koy
- A. Amouzougan
- E. Biver
- R. Chapurlat
- T. Chevalley
- S. L. Ferrari
- A. Fouilloux
- H. Locrelle
- H. Marotte
- M. Normand
- R. Rizzoli
- L. Vico
- T. Thomas
- Erschienen in
- Osteoporosis International | Ausgabe 3/2022
Abstract
Summary
Bone microarchitecture assessed by high-resolution peripheral quantitative computed tomography varies across populations of different origin. The study presents a reference dataset of microarchitectural parameters in a homogeneous group of participants aged within 22–27 range determined by a discriminant analysis of a larger cross-sectional cohort of 339 women.
Introduction
High-resolution peripheral quantitative computed tomography (HR-pQCT) non-invasively measures three-dimensional bone microarchitectural parameters and volumetric bone mineral density. Previous studies established normative reference HR-pQCT datasets for several populations, but there were few data assessed in a reference group of young women with Caucasian ethnicity living in Western Europe. It is important to obtain different specific reference dataset for a valid interpretation of cortical and trabecular microarchitecture data. The aim of our study was to find the population with the most optimal bone status in order to establish a descriptive reference HR-pQCT dataset in a young and healthy normal-weight female cohort living in a European area including Geneva, Switzerland, Lyon and Saint-Etienne, France.
Methods
We constituted a cross-sectional cohort of 339 women aged 19–41 years with a BMI > 18 and < 30 kg/m2. All participants had HR-pQCT measurements at both non-dominant distal radius and tibia sites.
Results
We observed that microarchitectural parameters begin to decline before the age of 30 years. Based on a discriminant analysis, the optimal bone profile in this population was observed between the age range of 22 to 27 years. Consequently, we considered 43 participants aged 22–27 years to establish a reference dataset with median values and percentiles.
Conclusion
This is the first study providing reference values of HR-pQCT measurements considering specific age bounds in a Franco-Swiss female cohort at the distal radius and tibia sites.
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- Titel
- Reference microarchitectural values measured by HR-pQCT in a Franco-Swiss cohort of young adult women
- Verfasst von
-
E. How Shing Koy
A. Amouzougan
E. Biver
R. Chapurlat
T. Chevalley
S. L. Ferrari
A. Fouilloux
H. Locrelle
H. Marotte
M. Normand
R. Rizzoli
L. Vico
T. Thomas
- Publikationsdatum
- 12.10.2021
- Verlag
- Springer London
- Erschienen in
-
Osteoporosis International / Ausgabe 3/2022
Print ISSN: 0937-941X
Elektronische ISSN: 1433-2965 - DOI
- https://doi.org/10.1007/s00198-021-06193-x
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