Skip to main content
main-content

30.04.2016 | Ausgabe 10/2016

Quality of Life Research 10/2016

Refined comorbidity index based on dimensionality of comorbidity for use in studies of health-related quality of life

Zeitschrift:
Quality of Life Research > Ausgabe 10/2016
Autoren:
Huang-Tz Ou, Chung-Ying Lin, Steven R. Erickson, Rajesh Balkrishnan
Wichtige Hinweise

Electronic supplementary material

The online version of this article (doi:10.​1007/​s11136-016-1306-6) contains supplementary material, which is available to authorized users.

Abstract

Purpose

To refine two subscales of the health-related quality of life comorbidity index (HRQoL-CI) into a single index measure.

Methods

The 2010 and 2012 Medical Expenditure Panel Surveys were utilized as development and validation datasets, respectively. The least absolute shrinkage and selection operator was applied to select important comorbidity candidates associated with HRQoL. Exploratory factor analysis and confirmatory factor analysis (CFA) were used to assess dimensionality in comorbidity. Statistical weights were derived based on standardized factor loadings from CFA and regression coefficients from the model predicting HRQoL. Prediction errors and model R2 values were compared between HRQoL-CI and Charlson CI (CCI).

Results

Eighteen comorbid conditions were identified. CFA models indicated that the second-order multidimensional comorbidity structure had a better fit to the data than did the first-order unidimensional structure. The predictive performance of the refined scale under a multidimensional structure utilizing statistical weights outperformed the original scale and CCI in terms of average prediction error and R2 in the prediction models (R2 values from refined scale model are 0.25, 0.30, and 0.28 versus those from CCI of 0.10, 0.09, and 0.06 for general health, SF-6D, and EQ-5D, respectively).

Conclusion

The dimensionality of comorbidity and the weight scheme significantly improved the performance of the refined HRQoL-CI. The refined single HRQoL-CI measure appears to be an appropriate and valid instrument specific for risk adjustment in studies of HRQoL. Future research that validates the refined scales for different cultures, age groups, and healthcare settings is warranted.

Bitte loggen Sie sich ein, um Zugang zu diesem Inhalt zu erhalten

★ PREMIUM-INHALT
e.Med Interdisziplinär

Mit e.Med Interdisziplinär erhalten Sie Zugang zu allen CME-Fortbildungen und Fachzeitschriften auf SpringerMedizin.de. Zusätzlich können Sie eine Zeitschrift Ihrer Wahl in gedruckter Form beziehen – ohne Aufpreis.

Jetzt e.Med zum Sonderpreis bestellen!

Zusatzmaterial
Supplementary material 1 (DOCX 20 kb)
11136_2016_1306_MOESM1_ESM.docx
Literatur
Über diesen Artikel

Weitere Artikel der Ausgabe 10/2016

Quality of Life Research 10/2016 Zur Ausgabe