Skip to main content
main-content
Erschienen in: HNO 5/2010

01.05.2010 | Leitthema

Regeneration des N. facialis im Vergleich zu anderen peripheren Nerven

Aktuelles aus der Forschung für die Klinik

verfasst von: PD Dr. A. Irintchev, D.N. Angelov, O. Guntinas-Lichius

Erschienen in: HNO | Ausgabe 5/2010

Einloggen, um Zugang zu erhalten

Zusammenfassung

Das Wissen über die entscheidenden zellulären und molekularen Mechanismen der peripheren Nervenregeneration nimmt zu. Doch es gibt keine effektive Therapie peripherer Nervenverletzungen in der Klinik. Neue quantitative Ansätze zur Vermessung motorischer Defizite ermöglichten Studien innovativer Therapien im Tierexperiment: Funktionell wirkt sich v. a. die tägliche manuelle Stimulation denervierter Muskulatur bei erhaltenem sensorischem Input nach Nervenrekonstruktion gut aus. Sie scheint bei Läsionen des N. facialis geeignet für eine schnelle Translation in den klinischen Alltag. Dagegen scheint die manuelle Stimulation ineffektiv bei Läsionen gemischter peripherer Nerven zu sein. Bei Nagetieren wurde langfristig durch Elektrostimulation die Nervenregeneration nicht besser. Eine kurzzeitige Elektrostimulation direkt nach Trauma des N. facialis hat keinen signifikanten Effekt. Die wiederholte Elektrostimulation der Muskulatur in den Phasen der De- und Reinnervation behindert sogar die Muskelreinnervation. Medikamentös scheint die Applikation von Glykomimetika, Peptiden, die funktionelle Eigenschaften von Karbohydratmolekülen imitieren, besonders vielversprechend für die periphere Nervenregeneration.
Literatur
1.
Zurück zum Zitat Ahlborn P, Schachner M, Irintchev A (2007) One hour electrical stimulation accelerates functional recovery after femoral nerve repair. Exp Neurol 208:137–144 CrossRefPubMed Ahlborn P, Schachner M, Irintchev A (2007) One hour electrical stimulation accelerates functional recovery after femoral nerve repair. Exp Neurol 208:137–144 CrossRefPubMed
2.
Zurück zum Zitat Al-Majed A, Brushart T, Gordon T (2000) Electrical stimulation accelerates and increases expression of BDNF and trkB mRNA in regenerating rat femoral motoneurons. Eur J Neurosci 12:4381–4390 PubMed Al-Majed A, Brushart T, Gordon T (2000) Electrical stimulation accelerates and increases expression of BDNF and trkB mRNA in regenerating rat femoral motoneurons. Eur J Neurosci 12:4381–4390 PubMed
3.
Zurück zum Zitat Al-Majed A, Neumann C, Brushart T et al (2000) Brief electrical stimulation promotes the speed and accuracy of motor axonal regeneration. J Neurosci 20:2602–2608 PubMed Al-Majed A, Neumann C, Brushart T et al (2000) Brief electrical stimulation promotes the speed and accuracy of motor axonal regeneration. J Neurosci 20:2602–2608 PubMed
4.
Zurück zum Zitat Angelov DN, Ceynowa M, Guntinas-Lichius O et al (2007) Mechanical stimulation of paralyzed vibrissal muscles following facial nerve injury in adult rat promotes full recovery of whisking. Neurobiol Dis 26:229–242 CrossRefPubMed Angelov DN, Ceynowa M, Guntinas-Lichius O et al (2007) Mechanical stimulation of paralyzed vibrissal muscles following facial nerve injury in adult rat promotes full recovery of whisking. Neurobiol Dis 26:229–242 CrossRefPubMed
5.
Zurück zum Zitat Angelov DN, Skouras E, Guntinas-Lichius O et al (1999) Contralateral trigeminal nerve lesion reduces polyneuronal muscle innervation after facial nerve repair in rats. Eur J Neurosci 11:1369–1378 CrossRefPubMed Angelov DN, Skouras E, Guntinas-Lichius O et al (1999) Contralateral trigeminal nerve lesion reduces polyneuronal muscle innervation after facial nerve repair in rats. Eur J Neurosci 11:1369–1378 CrossRefPubMed
6.
Zurück zum Zitat Bischoff A, Grosheva M, Irintchev A et al (2009) Manual stimulation of the orbicularis oculi muscle improves eyelid closure after facial nerve injury in adult rats. Muscle Nerve 39:197–205 CrossRefPubMed Bischoff A, Grosheva M, Irintchev A et al (2009) Manual stimulation of the orbicularis oculi muscle improves eyelid closure after facial nerve injury in adult rats. Muscle Nerve 39:197–205 CrossRefPubMed
7.
Zurück zum Zitat Brushart TM (1993) Motor axons preferentially reinnervate motor pathways. J Neurosci 13:2730–2738 PubMed Brushart TM (1993) Motor axons preferentially reinnervate motor pathways. J Neurosci 13:2730–2738 PubMed
8.
Zurück zum Zitat Brushart TM (1988) Preferential reinnervation of motor nerves by regenerating motor axons. J Neurosci 8:1026–1031 PubMed Brushart TM (1988) Preferential reinnervation of motor nerves by regenerating motor axons. J Neurosci 8:1026–1031 PubMed
9.
Zurück zum Zitat Brushart TM, Hoffman PN, Royall RM et al (2002) Electrical stimulation promotes motoneuron regeneration without increasing its speed or conditioning the neuron. J Neurosci 22:6631–6638 PubMed Brushart TM, Hoffman PN, Royall RM et al (2002) Electrical stimulation promotes motoneuron regeneration without increasing its speed or conditioning the neuron. J Neurosci 22:6631–6638 PubMed
10.
Zurück zum Zitat Evgenieva E, Schweigert P, Guntinas-Lichius O et al (2008) Manual stimulation of the suprahyoid-sublingual region diminishes polynnervation of the motor endplates and improves recovery of function after hypoglossal nerve injury in rats. Neurorehabil Neural Repair 22:754–768 CrossRefPubMed Evgenieva E, Schweigert P, Guntinas-Lichius O et al (2008) Manual stimulation of the suprahyoid-sublingual region diminishes polynnervation of the motor endplates and improves recovery of function after hypoglossal nerve injury in rats. Neurorehabil Neural Repair 22:754–768 CrossRefPubMed
11.
Zurück zum Zitat Gordon T, Chan K, Sulaiman O et al (2009) Accelerating axon growth to overcome limitations in functional recovery after peripheral nerve injury. Neurosurgery 65:132–144 CrossRef Gordon T, Chan K, Sulaiman O et al (2009) Accelerating axon growth to overcome limitations in functional recovery after peripheral nerve injury. Neurosurgery 65:132–144 CrossRef
12.
Zurück zum Zitat Guntinas-Lichius O, Angelov D (2008) Experimentelle Untersuchungen zur Verbesserung der Fazialisregeneration. HNO 56:122–130 CrossRefPubMed Guntinas-Lichius O, Angelov D (2008) Experimentelle Untersuchungen zur Verbesserung der Fazialisregeneration. HNO 56:122–130 CrossRefPubMed
13.
Zurück zum Zitat Guntinas-Lichius O, Hundeshagen G, Paling T et al (2007) Manual stimulation of facial muscles improves functional recovery after hypoglossal-facial anastomosis and interpositional nerve grafting of the facial nerve in adult rats. Neurobiol Dis 28:101–112 CrossRefPubMed Guntinas-Lichius O, Hundeshagen G, Paling T et al (2007) Manual stimulation of facial muscles improves functional recovery after hypoglossal-facial anastomosis and interpositional nerve grafting of the facial nerve in adult rats. Neurobiol Dis 28:101–112 CrossRefPubMed
14.
Zurück zum Zitat Guntinas-Lichius O, Irintchev A, Streppel M et al (2005) Factors limiting motor recovery after facial nerve transection in the rat: combined structural and functional analyses. Eur J Neurosci 21:391–402 CrossRefPubMed Guntinas-Lichius O, Irintchev A, Streppel M et al (2005) Factors limiting motor recovery after facial nerve transection in the rat: combined structural and functional analyses. Eur J Neurosci 21:391–402 CrossRefPubMed
15.
Zurück zum Zitat Guntinas-Lichius O, Straesser A, Streppel M (2007) Quality of life after facial nerve repair. Laryngoscope 117:421–426 CrossRefPubMed Guntinas-Lichius O, Straesser A, Streppel M (2007) Quality of life after facial nerve repair. Laryngoscope 117:421–426 CrossRefPubMed
16.
Zurück zum Zitat Guseva D, Angelov D, Irintchev A et al (2009) Ablation of adhesion molecule L1 in mice favours Schwann cell proliferation and functional recovery after peripheral nerve injury. Brain 132:2180–2195 CrossRefPubMed Guseva D, Angelov D, Irintchev A et al (2009) Ablation of adhesion molecule L1 in mice favours Schwann cell proliferation and functional recovery after peripheral nerve injury. Brain 132:2180–2195 CrossRefPubMed
17.
Zurück zum Zitat Irintchev A, Simova O, Eberhardt K et al (2005) Impacts of lesion severity and tyrosine kinase receptor B deficiency on functional outcome of femoral nerve injury assessed by a novel single-frame motion analysis in mice. Eur J Neurosci 22:802–808 CrossRefPubMed Irintchev A, Simova O, Eberhardt K et al (2005) Impacts of lesion severity and tyrosine kinase receptor B deficiency on functional outcome of femoral nerve injury assessed by a novel single-frame motion analysis in mice. Eur J Neurosci 22:802–808 CrossRefPubMed
18.
Zurück zum Zitat Irintchev A, Wu M, Lee HJ et al (2009) Efficient glycomimetic treatment of femoral nerve injury in primates (Macaca fascicularis). Neurorehabil Neural Repair 33 (Abstract) Irintchev A, Wu M, Lee HJ et al (2009) Efficient glycomimetic treatment of femoral nerve injury in primates (Macaca fascicularis). Neurorehabil Neural Repair 33 (Abstract)
19.
Zurück zum Zitat Kleene R, Schachner M (2004) Glycans and neural cell interactions. Nat Rev Neurosci 5:195–208 CrossRefPubMed Kleene R, Schachner M (2004) Glycans and neural cell interactions. Nat Rev Neurosci 5:195–208 CrossRefPubMed
20.
Zurück zum Zitat Mehanna A, Jakovcevski I, Acar A et al (2009) Polysialic Acid Glycomimetic Promotes Functional Recovery and Plasticity After Spinal Cord Injury in Mice. Mol Ther 18:34–43 CrossRefPubMed Mehanna A, Jakovcevski I, Acar A et al (2009) Polysialic Acid Glycomimetic Promotes Functional Recovery and Plasticity After Spinal Cord Injury in Mice. Mol Ther 18:34–43 CrossRefPubMed
21.
Zurück zum Zitat Mehanna A, Mishra B, Kurschat N et al (2009) Polysialic acid glycomimetics promote myelination and functional recovery after peripheral nerve injury in mice. Brain 132:1449–1462 CrossRefPubMed Mehanna A, Mishra B, Kurschat N et al (2009) Polysialic acid glycomimetics promote myelination and functional recovery after peripheral nerve injury in mice. Brain 132:1449–1462 CrossRefPubMed
22.
Zurück zum Zitat Pavlov S, Grosheva M, Streppel M et al (2008) Manually-stimulated recovery of motor function after facial nerve injury requires intact sensory input. Exp Neurol 211:292–300 CrossRefPubMed Pavlov S, Grosheva M, Streppel M et al (2008) Manually-stimulated recovery of motor function after facial nerve injury requires intact sensory input. Exp Neurol 211:292–300 CrossRefPubMed
23.
Zurück zum Zitat Peeva GP, Angelova SK, Guntinas-Lichius O et al (2006) Improved outcome of facial nerve repair in rats is associated with enhanced regenerative response of motoneurons and augmented neocortical plasticity. Eur J Neurosci 24:2152–2162 CrossRefPubMed Peeva GP, Angelova SK, Guntinas-Lichius O et al (2006) Improved outcome of facial nerve repair in rats is associated with enhanced regenerative response of motoneurons and augmented neocortical plasticity. Eur J Neurosci 24:2152–2162 CrossRefPubMed
24.
Zurück zum Zitat Rutishauser U (2008) Polysialic acid in the plasticity of the developing and adult vertebrate nervous system. Nat Rev Neurosci 9:26–35 CrossRefPubMed Rutishauser U (2008) Polysialic acid in the plasticity of the developing and adult vertebrate nervous system. Nat Rev Neurosci 9:26–35 CrossRefPubMed
25.
Zurück zum Zitat Simova O, Irintchev A, Mehanna A et al (2006) Carbohydrate mimics promote functional recovery after peripheral nerve repair. Ann Neurol 60:430–437 CrossRefPubMed Simova O, Irintchev A, Mehanna A et al (2006) Carbohydrate mimics promote functional recovery after peripheral nerve repair. Ann Neurol 60:430–437 CrossRefPubMed
26.
Zurück zum Zitat Sinis N, Guntinas-Lichius O, Irintchev A et al (2008) Manual stimulation of forearm muscles does not improve recovery of motor function after injury to a mixed peripheral nerve. Exp Brain Res 185:469–483 CrossRefPubMed Sinis N, Guntinas-Lichius O, Irintchev A et al (2008) Manual stimulation of forearm muscles does not improve recovery of motor function after injury to a mixed peripheral nerve. Exp Brain Res 185:469–483 CrossRefPubMed
27.
Zurück zum Zitat Sinis N, Horn F, Genchev B et al (2009) Electrical stimulation of paralyzed vibrissal muscles reduces endplate reinnervation and does not promote motor recovery after facial nerve repair in rats. Ann Anat 191:356–370 CrossRefPubMed Sinis N, Horn F, Genchev B et al (2009) Electrical stimulation of paralyzed vibrissal muscles reduces endplate reinnervation and does not promote motor recovery after facial nerve repair in rats. Ann Anat 191:356–370 CrossRefPubMed
28.
Zurück zum Zitat Skouras E, Merkel D, Grosheva M et al (2009) Manual stimulation, but not acute electrical stimulation prior to reconstructive surgery, improves functional recovery after facial nerve injury in rats. Restor Neurol Neurosci 27:237–251 PubMed Skouras E, Merkel D, Grosheva M et al (2009) Manual stimulation, but not acute electrical stimulation prior to reconstructive surgery, improves functional recovery after facial nerve injury in rats. Restor Neurol Neurosci 27:237–251 PubMed
29.
Zurück zum Zitat Skouras E, Popratiloff A, Guntinas-Lichius O et al (2002) Altered sensory input improves the accuracy of muscle reinnervation. Restor Neurol Neurosci 20:1–14 PubMed Skouras E, Popratiloff A, Guntinas-Lichius O et al (2002) Altered sensory input improves the accuracy of muscle reinnervation. Restor Neurol Neurosci 20:1–14 PubMed
30.
Zurück zum Zitat Tomov TL, Guntinas-Lichius O, Grosheva M et al (2002) An example of neural plasticity evoked by putative behavioral demand and early use of vibrissal hairs after facial nerve transection. Exp Neurol 178:207–218 CrossRefPubMed Tomov TL, Guntinas-Lichius O, Grosheva M et al (2002) An example of neural plasticity evoked by putative behavioral demand and early use of vibrissal hairs after facial nerve transection. Exp Neurol 178:207–218 CrossRefPubMed
Metadaten
Titel
Regeneration des N. facialis im Vergleich zu anderen peripheren Nerven
Aktuelles aus der Forschung für die Klinik
verfasst von
PD Dr. A. Irintchev
D.N. Angelov
O. Guntinas-Lichius
Publikationsdatum
01.05.2010
Verlag
Springer-Verlag
Erschienen in
HNO / Ausgabe 5/2010
Print ISSN: 0017-6192
Elektronische ISSN: 1433-0458
DOI
https://doi.org/10.1007/s00106-010-2100-3