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Endocrine

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25.11.2021 | Review

Regenerative approaches to preserve pancreatic β-cell mass and function in diabetes pathogenesis

verfasst von: Maria Fernanda Desentis-Desentis

Erschienen in: Endocrine | Ausgabe 2/2022

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Abstract

In both type 1 diabetes (T1D) and type 2 diabetes (T2D), there is a substantial β-cell mass loss. Residual β-cell mass is susceptible to cellular damage because of specific pancreatic β-cell characteristics. β cells have a low proliferation rate, being in human adults almost zero and a low antioxidant system that makes β cells susceptible to oxidative stress and increases their vulnerability to cell destruction. Different strategies have been addressed to preserve pancreatic β-cell residual mass and function in patients with diabetes. However, the effect of many compounds proposed in rodent models to trigger β-cell replication has different results in human β cells. In this review, scientific evidence of β-cell of two major regenerative approaches has been gathered. Regeneration proceedings for pancreatic β cells are promising and could improve β-cell proliferation capacity and contribute to the conservation of mature β-cell phenotypic characteristics. This evidence supports the notion that regenerative medicine could be a helpful strategy to yield amelioration of T1D and T2D pathogenesis.

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Titel: Regenerative approaches to preserve pancreatic β-cell mass and function in diabetes pathogenesis
verfasst von: Maria Fernanda Desentis-Desentis
Publikationsdatum: 25.11.2021
Verlag: Springer US
Erschienen in: Endocrine / Ausgabe 2/2022
Print ISSN: 1355-008X
Elektronische ISSN: 1559-0100
DOI: https://doi.org/10.1007/s12020-021-02941-5

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