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Erschienen in: Basic Research in Cardiology 4/2008

01.06.2008 | ORIGINAL CONTRIBUTION

Regional and temporal heterogeneity of postsystolic wall thickening is associated with left ventricular asynchrony in normal and experimental stunned myocardium

verfasst von: Laurence Lucats, Xavier Monnet, Alain Bizé, Valérie Chetboul, Jean-Louis Pouchelon, Luc Hittinger, Alain Berdeaux, Bijan Ghaleh

Erschienen in: Basic Research in Cardiology | Ausgabe 4/2008

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Abstract

Aims

Postsystolic wall thickening (PSWT) occurs after aortic valve closure. We investigated the influence of ischemia location and wall interactions on PSWT in normal and stunned myocardium.

Methods and results

Twenty-two dogs were studied. Seven chronically instrumented dogs (sonomicrometry) underwent 10-min coronary artery occlusion (CAO) of left circumflex artery (“LCX stunning”) and seven other dogs underwent 10-min CAO of the anterior descending artery (“LAD stunning”) followed by reperfusion. At baseline, there was no PSWT in the anterior wall whereas posterior wall started and finished to thicken after the anterior wall, demonstrating PSWT. With LCX stunning, PSWT was observed in the posterior wall without affecting the remote anterior wall. With LAD stunning, PSWT in the anterior wall was transient and of lower magnitude Vs. posterior wall; in the remote posterior wall, PSWT previously observed at baseline, almost vanished. Postsystolic to systolic wall thickening ratio identified (ROC analysis) normal, ischemic and stunned myocardium with different amplitudes between walls. Tissue Doppler Imaging demonstrated similar pattern in basal, mid and apical segments (additional n = 4 for both LCX and LAD stunning).

Conclusion

The present study demonstrates that location of ischemia and wall interactions produce discrepancies in PSWT between anterior and posterior walls in stunned myocardium.
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Metadaten
Titel
Regional and temporal heterogeneity of postsystolic wall thickening is associated with left ventricular asynchrony in normal and experimental stunned myocardium
verfasst von
Laurence Lucats
Xavier Monnet
Alain Bizé
Valérie Chetboul
Jean-Louis Pouchelon
Luc Hittinger
Alain Berdeaux
Bijan Ghaleh
Publikationsdatum
01.06.2008
Verlag
D. Steinkopff-Verlag
Erschienen in
Basic Research in Cardiology / Ausgabe 4/2008
Print ISSN: 0300-8428
Elektronische ISSN: 1435-1803
DOI
https://doi.org/10.1007/s00395-008-0716-1

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