Erschienen in:
07.03.2018 | Editorial commentary
Regional Genotyping of Rotavirus: Role in Vaccine Development
verfasst von:
Anshu Srivastava, Rishi Bolia
Erschienen in:
Indian Journal of Pediatrics
|
Ausgabe 5/2018
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Excerpt
Rotavirus is the most common cause of severe acute diarrhea in young children worldwide, resulting in >2 lac deaths annually [
1]. Viral serotypes are defined on the basis of outer capsid proteins VP4 (P serotype) and VP7 (G serotype). Till date, at least 24 G and 33 P genotypes have been identified and 12 G and 15 P serotypes are known to infect humans. Development of a protective immune response after primary infection that reduces symptom severity on re-infection is the basis for oral rotavirus vaccine development. …