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01.12.2012 | Original Paper

Regional reduction in gray and white matter volume in brains of cirrhotic patients: voxel-based analysis of MRI

verfasst von: Motoh Iwasa, Rumi Mifuji-Moroka, Makoto Kuroda, Hideo Moroka, Naoki Fujita, Yoshinao Kobayashi, Yukihiko Adachi, Esteban C. Gabazza, Hiroshi Matsuda, Yoshiyuki Takei

Erschienen in: Metabolic Brain Disease | Ausgabe 4/2012

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Abstract

Chronic hepatic encephalopathy is a characteristically reversible neuropsychiatric disorder that occurs mainly in patients with liver cirrhosis. The brain regions critically involved in the pathophysiology of cirrhosis are not clear. Magnetic resonance imaging (MRI) with voxel-based morphometry (VBM) is a valuable tool for evaluating structural brain changes in many neurodegenerative diseases. We performed an MRI scan on 18 patients with liver cirrhosis and 16 age-matched healthy controls. We evaluated brain regional structural changes, regional differences and the relationship of these changes with the blood levels of ammonia and the results of neuropsychological tests in patients with cirrhosis. The VBM showed reduction in the volume of gray matter in the cerebellum and occipital lobe and in the volume of white matter in the cingulate, parietal, temporal, occipital lobe and precentral area in cirrhotic patients compared with controls. There were significant correlations between the volume of these regions with the plasma levels of ammonia and the results of neuropsychological tests. Voxel-based analysis of MRI revealed evidence for structural abnormalities of brain in patients with cirrhosis. Abnormal function in the above regions may account for the ammonia-mediated changes and neuropsychological deficits in hepatic encephalopathy.

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Titel: Regional reduction in gray and white matter volume in brains of cirrhotic patients: voxel-based analysis of MRI
verfasst von: Motoh Iwasa
Rumi Mifuji-Moroka
Makoto Kuroda
Hideo Moroka
Naoki Fujita
Yoshinao Kobayashi
Yukihiko Adachi
Esteban C. Gabazza
Hiroshi Matsuda
Yoshiyuki Takei
Publikationsdatum: 01.12.2012
Verlag: Springer US
Erschienen in: Metabolic Brain Disease / Ausgabe 4/2012
Print ISSN: 0885-7490
Elektronische ISSN: 1573-7365
DOI: https://doi.org/10.1007/s11011-012-9314-x

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Regional reduction in gray and white matter volume in brains of cirrhotic patients: voxel-based analysis of MRI

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