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Arthritis Research & Therapy

Erschienen in:

01.12.2011 | Review

Regulation of bone by the adaptive immune system in arthritis

verfasst von: Kazuo Okamoto, Hiroshi Takayanagi

Erschienen in: Arthritis Research & Therapy | Ausgabe 3/2011

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Abstract

Studies on the immune regulation of osteoclasts in rheumatoid arthritis have promoted the new research field of 'osteoimmunology', which investigates the interplay between the skeletal and immune systems at the molecular level. Accumulating evidence lends support to the theory that bone destruction associated with rheumatoid arthritis is caused by the enhanced activity of osteoclasts, resulting from the activation of a unique helper T cell subset, 'Th17 cells'. Understanding the interaction between osteoclasts and the adaptive immune system in rheumatoid arthritis and the molecular mechanisms of Th17 development will lead to the development of potentially effective therapeutic strategies.

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Titel: Regulation of bone by the adaptive immune system in arthritis
verfasst von: Kazuo Okamoto
Hiroshi Takayanagi
Publikationsdatum: 01.12.2011
Verlag: BioMed Central
Erschienen in: Arthritis Research & Therapy / Ausgabe 3/2011
Elektronische ISSN: 1478-6362
DOI: https://doi.org/10.1186/ar3323

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Regulation of bone by the adaptive immune system in arthritis

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