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08.04.2019 | Review

Regulation of T cell differentiation and function by epigenetic modification enzymes

verfasst von: Huicheng Liu, Pingfei Li, Zhengping Wei, Cai Zhang, Minghui Xia, Qiuyang Du, Yufei Chen, Na Liu, Huabin Li, Xiang-Ping Yang

Erschienen in: Seminars in Immunopathology | Ausgabe 3/2019

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Abstract

Peripheral naive CD4⁺ and CD8⁺ cells are developed in the thymus and proliferate and differentiate into various specialized T cell subsets upon activation by peptide-major histocompatibility complexes in periphery to execute different functions during immune responses. Cytokines, transcription factors, and a large number of intracellular molecules have been shown to affect T cell development, activation, and function. In addition, epigenetic modifications, such as histone modification and DNA methylation, regulate T cell biology. The epigenetic modifications are regulated by a range of DNA methyltransferases, DNA demethylation enzymes, and histone modification enzymes. Dysregulations of epigenetic modifications are closely associated with autoimmune diseases and tumorigenesis. Here, we review the current literature about the functions of DNA and histone modification enzymes in T cell development, activation, differentiation, and function.

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Titel: Regulation of T cell differentiation and function by epigenetic modification enzymes
verfasst von: Huicheng Liu
Pingfei Li
Zhengping Wei
Cai Zhang
Minghui Xia
Qiuyang Du
Yufei Chen
Na Liu
Huabin Li
Xiang-Ping Yang
Publikationsdatum: 08.04.2019
Verlag: Springer Berlin Heidelberg
Erschienen in: Seminars in Immunopathology / Ausgabe 3/2019
Print ISSN: 1863-2297
Elektronische ISSN: 1863-2300
DOI: https://doi.org/10.1007/s00281-019-00731-w

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