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International Journal of Hematology

Erschienen in:

03.05.2018 | Progress in Hematology

Regulation of unfolded protein response in hematopoietic stem cells

verfasst von: Valgardur Sigurdsson, Kenichi Miharada

Erschienen in: International Journal of Hematology | Ausgabe 6/2018

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Abstract

Hematopoietic stem cells (HSCs) play a central role in hematopoietic regeneration, which has been demonstrated by thorough studies. In contrast, the cell cycle status and metabolic condition of HSCs define these cells as dormant. Recent studies have also revealed that protein metabolism is quite unique, as dormant HSCs have a lower protein synthesis rate and folding capacity. Under proliferative conditions, upon hematopoietic stress, HSCs need to deal with higher requirements of protein production to achieve fast and effective blood replenishment. In such cases, increased protein synthesis could exceed the capacity of precise protein quality control, leading to the accumulation of unfolded and misfolded proteins. In turn, this triggers endoplasmic reticulum (ER) stress as a part of the unfolded protein response (UPR). Since ER stress is a multi-layered, bidirectional cellular response that contains both positive (survival) and negative (death) reactions, proper management of UPR and ER stress signals is crucial for HSCs and also for maintaining the healthy hematopoietic system. In this review, we introduce the latest findings in this emerging field within hematopoiesis and HSC regulation.

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Titel: Regulation of unfolded protein response in hematopoietic stem cells
verfasst von: Valgardur Sigurdsson
Kenichi Miharada
Publikationsdatum: 03.05.2018
Verlag: Springer Japan
Erschienen in: International Journal of Hematology / Ausgabe 6/2018
Print ISSN: 0925-5710
Elektronische ISSN: 1865-3774
DOI: https://doi.org/10.1007/s12185-018-2458-7

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