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Journal of Cancer Research and Clinical Oncology
Erschienen in:

27.01.2022 | Review – Cancer Research

Regulatory effects of lncRNAs and miRNAs on the crosstalk between autophagy and EMT in cancer: a new era for cancer treatment

verfasst von: Lihui Si, Zecheng Yang, Lu Ding, Duoduo Zhang

Erschienen in: Journal of Cancer Research and Clinical Oncology | Ausgabe 3/2022

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Abstract

Purpose

Autophagy and EMT (epithelial–mesenchymal transition) are the two principal biological processes and ideal therapeutic targets during cancer development. Autophagy, a highly conserved process for degrading dysfunctional cellular components, plays a dual role in tumors depending on the tumor stage and tissue types. The EMT process is the transition differentiation from an epithelial cell to a mesenchymal-like cell and acquiring metastatic potential. There is evidence that the crosstalk between autophagy and EMT is complex in cancer. In recent years, more studies have shown that long non-coding RNAs (lncRNAs) and microRNAs (miRNAs) are involved in autophagy, EMT, and their crosstalk. Therefore, accurate understanding of the regulatory mechanisms of lncRNAs and miRNAs in autophagy, EMT and their interactions is crucial for the clinical management of cancers.

Methods

An extensive literature search was conducted on the Google Scholar and PubMed databases. The keywords used for the search included: autophagy, EMT, crosstalk, lncRNAs, miRNAs, cancers, diagnostic biomarkers, and therapeutic targets. This search provided relevant articles published in peer-reviewed journals until 2021. Data from these various studies were extracted and used in this review.

Results

The results showed that lncRNAs/miRNAs as tumor inhibitors or tumor inducers could regulate autophagy, EMT, and their interaction by regulating several molecular signaling pathways. The lncRNAs/miRNAs involved in autophagy and EMT processes could have potential uses in cancer diagnosis, prognosis, and therapy.

Conclusion

Such information could help find and develop lncRNAs/miRNAs based new tools for diagnosing, prognosis, and creating anti-cancer therapies.
Literatur
Acloque H, Adams MS, Fishwick K, Bronner-Fraser M, Nieto MA (2009) Epithelial-mesenchymal transitions: the importance of changing cell state in development and disease. J Clin Investig 119(6):1438–1449PubMedPubMedCentralCrossRef
Aiello NM, Brabletz T, Kang Y, Nieto MA, Weinberg RA, Stanger BZ (2017) Upholding a role for EMT in pancreatic cancer metastasis. Nature 547(7661):E7–E8PubMedPubMedCentralCrossRef
Al-Modawi RN, Brinchmann JE, Karlsen TA (2019) Multi-pathway protective effects of microRNAs on human chondrocytes in an in vitro model of osteoarthritis. Mol Therap-Nucleic Acids 17:776–790CrossRef
Bakhti SZ, Dadashi S, Pahlevan AD, Kafshresan F (2021) Functional roles and biological mechanisms of circular rnas and their encoded peptides in glioma: a narrative review. Int Clin Neurosci J 8(4):157–167CrossRef
Bermúdez M, Aguilar-Medina M, Lizárraga-Verdugo E, Avendaño-Félix M, Silva-Benítez E, López-Camarillo C, Ramos-Payán R (2019) LncRNAs as regulators of autophagy and drug resistance in colorectal cancer. Front Oncol 9:1008PubMedPubMedCentralCrossRef
Bertrand M, Petit V, Jain A, Amsellem R, Johansen T, Larue L, Codogno P, Beau I (2015) SQSTM1/p62 regulates the expression of junctional proteins through epithelial-mesenchymal transition factors. Cell Cycle 14(3):364–374PubMedPubMedCentralCrossRef
Brabletz T, Kalluri R, Nieto MA, Weinberg RA (2018) EMT in cancer. Nat Rev Cancer 18(2):128–134PubMedCrossRef
Butler DE, Marlein C, Walker HF, Frame FM, Mann VM, Simms MS, Davies BR, Collins AT, Maitland NJ (2017) Inhibition of the PI3K/AKT/mTOR pathway activates autophagy and compensatory Ras/Raf/MEK/ERK signalling in prostate cancer. Oncotarget 8(34):56698PubMedPubMedCentralCrossRef
Catalano M, D’Alessandro G, Lepore F, Corazzari M, Caldarola S, Valacca C, Faienza F, Esposito V, Limatola C, Cecconi F (2015) Autophagy induction impairs migration and invasion by reversing EMT in glioblastoma cells. Mol Oncol 9(8):1612–1625PubMedPubMedCentralCrossRef
Cech TR, Steitz JA (2014) The noncoding RNA revolution—trashing old rules to forge new ones. Cell 157(1):77–94PubMedCrossRef
Chen J, Cai S, Gu T, Song F, Xue Y, Sun D (2021) MiR-140-3p impedes gastric cancer progression and metastasis by regulating BCL2/BECN1-mediated autophagy. Onco Targets Ther 14:2879PubMedPubMedCentralCrossRef
Clemson CM, Hutchinson JN, Sara SA, Ensminger AW, Fox AH, Chess A, Lawrence JB (2009) An architectural role for a nuclear noncoding RNA: NEAT1 RNA is essential for the structure of paraspeckles. Mol Cell 33(6):717–726PubMedPubMedCentralCrossRef
Cogill SB, Wang L (2014) Co-expression network analysis of human lncRNAs and cancer genes. Cancer Inform 13:CIN. S14070CrossRef
Cui Y, Wu F, Tian D, Wang T, Lu T, Huang X, Zhang P, Qin L (2018) miR-199a-3p enhances cisplatin sensitivity of ovarian cancer cells by targeting ITGB8. Oncol Rep 39(4):1649–1657PubMedPubMedCentral
De Craene B, Berx G (2013) Regulatory networks defining EMT during cancer initiation and progression. Nat Rev Cancer 13(2):97–110PubMedCrossRef
Degenhardt K, Mathew R, Beaudoin B, Bray K, Anderson D, Chen G, Mukherjee C, Shi Y, Gélinas C, Fan Y (2006) Autophagy promotes tumor cell survival and restricts necrosis, inflammation, and tumorigenesis. Cancer Cell 10(1):51–64PubMedPubMedCentralCrossRef
Deng X, Feng N, Zheng M, Ye X, Lin H, Yu X, Gan Z, Fang Z, Zhang H (1861) Gao M (2017) PM2. 5 exposure-induced autophagy is mediated by lncRNA loc146880 which also promotes the migration and invasion of lung cancer cells. Biochim Biophys Acta (BBA)-Gen Subj 2:112–125
Ding L, Xu Y, Zhang W, Deng Y, Si M, Du Y, Yao H, Liu X, Ke Y, Si J (2010) MiR-375 frequently downregulated in gastric cancer inhibits cell proliferation by targeting JAK2. Cell Res 20(7):784–793PubMedCrossRef
Ding Y, Li X, Zhang Y, Zhang J (2020) Long non-coding RNA cancer susceptibility 9 (CASC9) up-regulates the expression of ERBB2 by inhibiting miR-193a-5p in colorectal cancer. Cancer Manag Res 12:1281PubMedPubMedCentralCrossRef
Dong W, Yao C, Teng X, Chai J, Yang X, Li B (2016) MiR-140-3p suppressed cell growth and invasion by downregulating the expression of ATP8A1 in non-small cell lung cancer. Tumor Biol 37(3):2973–2985CrossRef
Fu J-w, Kong Y, Sun X (2016) Long noncoding RNA NEAT1 is an unfavorable prognostic factor and regulates migration and invasion in gastric cancer. J Cancer Res Clin Oncol 142(7):1571–1579PubMedCrossRef
Gibson NW (2006) Therapeutic opportunities associated with EMT and cancer prevention. AACR 15(12 Suppl):ED01–03
Gomes LR, Vessoni AT, Menck CF (2016) Microenvironment and autophagy cross-talk: implications in cancer therapy. Pharmacol Res 107:300–307PubMedCrossRef
Gong X, Wang H, Ye Y, Shu Y, Deng Y, He X, Lu G, Zhang S (2016) miR-124 regulates cell apoptosis and autophagy in dopaminergic neurons and protects them by regulating AMPK/mTOR pathway in Parkinson’s disease. Am J Transl Res 8(5):2127PubMedPubMedCentral
Grassi G, Di Caprio G, Santangelo L, Fimia G, Cozzolino A, Komatsu M, Ippolito G, Tripodi M, Alonzi T (2015) Autophagy regulates hepatocyte identity and epithelial-to-mesenchymal and mesenchymal-to-epithelial transitions promoting Snail degradation. Cell Death Dis 6(9):e1880–e1880PubMedPubMedCentralCrossRef
Gu D-n, Jiang M-j, Mei Z, Dai J-j, Dai C-y, Fang C, Huang Q, Tian L (2017) microRNA-7 impairs autophagy-derived pools of glucose to suppress pancreatic cancer progression. Cancer Lett 400:69–78PubMedCrossRef
Gugnoni M, Sancisi V, Manzotti G, Gandolfi G, Ciarrocchi A (2016) Autophagy and epithelial–mesenchymal transition: an intricate interplay in cancer. Cell Death Dis 7(12):e2520–e2520PubMedPubMedCentralCrossRef
Gugnoni M, Sancisi V, Gandolfi G, Manzotti G, Ragazzi M, Giordano D, Tamagnini I, Tigano M, Frasoldati A, Piana S (2017) Cadherin-6 promotes EMT and cancer metastasis by restraining autophagy. Oncogene 36(5):667–677PubMedCrossRef
Guo JY, Teng X, Laddha SV, Ma S, Van Nostrand SC, Yang Y, Khor S, Chan CS, Rabinowitz JD, White E (2016) Autophagy provides metabolic substrates to maintain energy charge and nucleotide pools in Ras-driven lung cancer cells. Genes Dev 30(15):1704–1717PubMedPubMedCentralCrossRef
Guo X, Xiao H, Guo S, Li J, Wang Y, Chen J, Lou G (2018) Long noncoding RNA HOTAIR knockdown inhibits autophagy and epithelial-mesenchymal transition through the Wnt signaling pathway in radioresistant human cervical cancer HeLa cells. J Cell Physiol 234(4):3478–3489PubMedCrossRef
Guo Q, Jing F-J, Xu W, Li X, Li X, Sun J-L, Xing X-M, Zhou C-K, Jing F-B (2020) Ubenimex induces autophagy inhibition and EMT suppression to overcome cisplatin resistance in GC cells by perturbing the CD13/EMP3/PI3K/AKT/NF-κB axis. Aging (albany NY) 12(1):80CrossRef
Han X, Tai H, Wang X, Wang Z, Zhou J, Wei X, Ding Y, Gong H, Mo C, Zhang J (2016) AMPK activation protects cells from oxidative stress-induced senescence via autophagic flux restoration and intracellular NAD+ elevation. Aging Cell 15(3):416–427PubMedPubMedCentralCrossRef
Han LL, Jia L, Wu F, Huang C (2019) Sirtuin6 (SIRT6) promotes the EMT of hepatocellular carcinoma by stimulating autophagic degradation of E-cadherin. Mol Cancer Res 17(11):2267–2280PubMedCrossRef
He C, Jiang B, Ma J, Li Q (2016) Aberrant NEAT 1 expression is associated with clinical outcome in high grade glioma patients. APMIS 124(3):169–174PubMedCrossRef
He M, Lin Y, Xu Y (2019) Identification of prognostic biomarkers in colorectal cancer using a long non-coding RNA-mediated competitive endogenous RNA network. Oncol Lett 17(3):2687–2694PubMedPubMedCentral
Hu Y-L, Jahangiri A, DeLay M, Aghi MK (2012) Tumor cell autophagy as an adaptive response mediating resistance to treatments such as antiangiogenic therapy. Can Res 72(17):4294–4299CrossRef
Hu X, Bao J, Wang Z, Zhang Z, Gu P, Tao F, Cui D, Jiang W (2016) The plasma lncRNA acting as fingerprint in non-small-cell lung cancer. Tumor Biol 37(3):3497–3504CrossRef
Huang S, Lu W, Ge D, Meng N, Li Y, Su L, Zhang S, Zhang Y, Zhao B, Miao J (2015) A new microRNA signal pathway regulated by long noncoding RNA TGFB2-OT1 in autophagy and inflammation of vascular endothelial cells. Autophagy 11(12):2172–2183PubMedPubMedCentralCrossRef
Huang L, Cai JL, Huang PZ, Kang L, Huang MJ, Wang L, Wang JP (2017) miR19b-3p promotes the growth and metastasis of colorectal cancer via directly targeting ITGB8. Am J Cancer Res 7(10):1996PubMedPubMedCentral
Islam Khan MZ, Law HKW (2021) Cancer susceptibility candidate 9 (CASC9) promotes colorectal cancer carcinogenesis via mTOR-dependent autophagy and epithelial–mesenchymal transition pathways. Front Mol Biosci 8:206CrossRef
Ji L, Li L, Qu F, Zhang G, Wang Y, Bai X, Pan S, Xue D, Wang G, Sun B (2016) Hydrogen sulphide exacerbates acute pancreatitis by over-activating autophagy via AMPK/mTOR pathway. J Cell Mol Med 20(12):2349–2361PubMedPubMedCentralCrossRef
Jiang J, Tang Y-l, Liang X-h (2011) EMT: a new vision of hypoxia promoting cancer progression. Cancer Biol Ther 11(8):714–723PubMedCrossRef
Jiang W, Li T, Wang J, Jiao R, Shi X, Huang X, Ji G (2019) miR-140-3p suppresses cell growth and induces apoptosis in colorectal cancer by targeting PD-L1. Onco Targets Ther 12:10275PubMedPubMedCentralCrossRef
Jiashi W, Chuang Q, Zhenjun Z, Guangbin W, Bin L, Ming H (2018) MicroRNA-506-3p inhibits osteosarcoma cell proliferation and metastasis by suppressing RAB3D expression. Aging (albany NY) 10(6):1294CrossRef
Jin B, Jin D, Zhuo Z, Zhang B, Chen K (2020) MiR-1224-5p activates autophagy, cell invasion and inhibits epithelial-to-mesenchymal transition in osteosarcoma cells by directly targeting PLK1 through PI3K/AKT/mTOR signaling pathway. Onco Targets Ther 13:11807PubMedPubMedCentralCrossRef
Jing Z-F, Bi J-B, Li Z-L, Liu X-K, Li J, Zhu Y-Y, Zhang X-T, Zhang Z, Li Z-H, Kong C-Z (2019) miR-19 promotes the proliferation of clear cell renal cell carcinoma by targeting the FRK–PTEN axis. Onco Targets Ther 12:2713PubMedPubMedCentralCrossRef
Kang Y-H, Kim D, Jin E-J (2015) Down-regulation of phospholipase D stimulates death of lung cancer cells involving up-regulation of the long ncRNA ANRIL. Anticancer Res 35(5):2795–2803PubMed
Khan MZI, Law HK-W (2021) RAMS11 promotes CRC through mtor-dependent inhibition of autophagy, suppression of apoptosis, and promotion of epithelial-mesenchymal transition. Cancer Cell Int 21:321 CrossRef
Klionsky DJ (2007) Autophagy: from phenomenology to molecular understanding in less than a decade. Nat Rev Mol Cell Biol 8(11):931–937PubMedCrossRef
Kogo R, Shimamura T, Mimori K, Kawahara K, Imoto S, Sudo T, Tanaka F, Shibata K, Suzuki A, Komune S (2011) Long noncoding RNA HOTAIR regulates polycomb-dependent chromatin modification and is associated with poor prognosis in colorectal cancers. Can Res 71(20):6320–6326CrossRef
Kong X-M, Zhang G-H, Huo Y-K, Zhao X-H, Cao D-W, Guo S-F, Li A-M, Zhang X-R (2015) MicroRNA-140-3p inhibits proliferation, migration and invasion of lung cancer cells by targeting ATP6AP2. Int J Clin Exp Pathol 8(10):12845PubMedPubMedCentral
Kontomanolis N, Koukourakis MI (2015) MicroRNA: the potential regulator of endometrial carcinogenesis. Microrna 4(1):18–25PubMedCrossRef
Kumar D, Shankar S, Srivastava RK (2014) Rottlerin induces autophagy and apoptosis in prostate cancer stem cells via PI3K/Akt/mTOR signaling pathway. Cancer Lett 343(2):179–189PubMedCrossRef
Lai N-s, Dong Q-s, Ding H, Miao Z-l, Lin Y-c (2014) MicroRNA-210 overexpression predicts poorer prognosis in glioma patients. J Clin Neurosci 21(5):755–760PubMedCrossRef
Lee M, Kim HJ, Kim SW, Park S-A, Chun K-H, Cho NH, Song YS, Kim YT (2016) The long non-coding RNA HOTAIR increases tumour growth and invasion in cervical cancer by targeting the Notch pathway. Oncotarget 7(28):44558PubMedPubMedCentralCrossRef
Li J, Yang B, Zhou Q, Wu Y, Shang D, Guo Y, Song Z, Zheng Q, Xiong J (2013) Autophagy promotes hepatocellular carcinoma cell invasion through activation of epithelial–mesenchymal transition. Carcinogenesis 34(6):1343–1351PubMedCrossRef
Li L, Zhang L, Zhang Y, Zhou F (2015a) Increased expression of LncRNA BANCR is associated with clinical progression and poor prognosis in gastric cancer. Biomed Pharmacother 72:109–112PubMedCrossRef
Li Q, Shao Y, Zhang X, Zheng T, Miao M, Qin L, Wang B, Ye G, Xiao B, Guo J (2015b) Plasma long noncoding RNA protected by exosomes as a potential stable biomarker for gastric cancer. Tumor Biology 36(3):2007–2012PubMedCrossRef
Li Y, Li Y, Chen W, He F, Tan Z, Zheng J, Wang W, Zhao Q, Li J (2015c) NEAT expression is associated with tumor recurrence and unfavorable prognosis in colorectal cancer. Oncotarget 6(29):27641PubMedPubMedCentralCrossRef
Li J, Xia W, Su X, Qin X, Chen Y, Li S, Dong J, Ding H, Li H, Huang A (2016) Species-specific mutual regulation of p53 and miR-138 between human, rat and mouse. Sci Rep 6:26187PubMedPubMedCentralCrossRef
Li B, Wang L, Li Z, Wang W, Zhi X, Huang X, Zhang Q, Chen Z, Zhang X, He Z (2017a) miR-3174 contributes to apoptosis and autophagic cell death defects in gastric cancer cells by targeting ARHGAP10. Mol Ther-Nucleic Acids 9:294–311PubMedPubMedCentralCrossRef
Li L-J, Chai Y, Guo X-J, Chu S-L, Zhang L-S (2017b) The effects of the long non-coding RNA MALAT-1 regulated autophagy-related signaling pathway on chemotherapy resistance in diffuse large B-cell lymphoma. Biomed Pharmacother 89:939–948PubMedCrossRef
Li W, Yan P, Meng X, Zhang J, Yang Y (2021) The microRNA cluster miR-214/miR-3120 prevents tumor cell switching from an epithelial to a mesenchymal-like phenotype and inhibits autophagy in gallbladder cancer. Cell Signal 80:109887PubMedCrossRef
Liang W-C, Fu W-M, Wong C-W, Wang Y, Wang W-M, Hu G-X, Zhang L, Xiao L-J, Wan DC-C, Zhang J-F (2015) The lncRNA H19 promotes epithelial to mesenchymal transition by functioning as miRNA sponges in colorectal cancer. Oncotarget 6(26):22513PubMedPubMedCentralCrossRef
Liang F, Ren C, Wang J, Wang S, Yang L, Han X, Chen Y, Tong G, Yang G (2019) The crosstalk between STAT3 and p53/RAS signaling controls cancer cell metastasis and cisplatin resistance via the Slug/MAPK/PI3K/AKT-mediated regulation of EMT and autophagy. Oncogenesis 8(10):1–15CrossRef
Liang C, Xu J, Meng Q, Zhang B, Liu J, Hua J, Zhang Y, Shi S, Yu X (2020) TGFB1-induced autophagy affects the pattern of pancreatic cancer progression in distinct ways depending on SMAD4 status. Autophagy 16(3):486–500PubMedCrossRef
Liu Y, Luo F, Xu Y, Wang B, Zhao Y, Xu W, Shi L, Lu X, Liu Q (2015b) Epithelial-mesenchymal transition and cancer stem cells, mediated by a long non-coding RNA, HOTAIR, are involved in cell malignant transformation induced by cigarette smoke extract. Toxicol Appl Pharmacol 282(1):9–19PubMedCrossRef
Liu Y, Liu R, Yang F, Cheng R, Chen X, Cui S, Gu Y, Sun W, You C, Liu Z (2017) miR-19a promotes colorectal cancer proliferation and migration by targeting TIA1. Mol Cancer 16(1):1–17CrossRef
Liu W, Wang X, Wang Y, Dai Y, Xie Y, Ping Y, Yin B, Yu P, Liu Z, Duan X (2018) SGK1 inhibition-induced autophagy impairs prostate cancer metastasis by reversing EMT. J Exp Clin Cancer Res 37(1):1–12PubMedPubMedCentralCrossRef
Liu W, Jiang D, Gong F, Huang Y, Luo Y, Rong Y, Wang J, Ge X, Ji C, Fan J (2020) miR-210-5p promotes epithelial–mesenchymal transition by inhibiting PIK3R5 thereby activating oncogenic autophagy in osteosarcoma cells. Cell Death Dis 11(2):1–15CrossRef
Livesey KM, Tang D, Zeh HJ, Lotze MT (2009) Autophagy inhibition in combination cancer treatment. Curr Opin Investig Drugs (london, England: 2000) 10(12):1269–1279
Lopez-Serra P, Esteller M (2012) DNA methylation-associated silencing of tumor-suppressor microRNAs in cancer. Oncogene 31(13):1609–1622PubMedCrossRef
Lu Y, Xiao L, Liu Y, Wang H, Li H, Zhou Q, Pan J, Lei B, Huang A, Qi S (2015) MIR517C inhibits autophagy and the epithelial-to-mesenchymal (-like) transition phenotype in human glioblastoma through KPNA2-dependent disruption of TP53 nuclear translocation. Autophagy 11(12):2213–2232PubMedPubMedCentralCrossRef
Luo J, Wu J, Li Z, Qin H, Wang B, Wong T-S, Yang W, Fu Q-L, Lei W (2014) miR-375 suppresses IGF1R expression and contributes to inhibition of cell progression in laryngeal squamous cell carcinoma. Biomed Res Int 2014:374598PubMedPubMedCentralCrossRef
Luo K, Geng J, Zhang Q, Xu Y, Zhou X, Huang Z, Shi K-Q, Pan C, Wu J (2019) LncRNA CASC9 interacts with CPSF3 to regulate TGF-β signaling in colorectal cancer. J Exp Clin Cancer Res 38(1):1–16CrossRef
Lv Q, Hua F, Hu Z-W (2012a) DEDD, a novel tumor repressor, reverses epithelial-mesenchymal transition by activating selective autophagy. Autophagy 8(11):1675–1676PubMedPubMedCentralCrossRef
Lv Q, Wang W, Xue J, Hua F, Mu R, Lin H, Yan J, Lv X, Chen X, Hu Z-W (2012b) DEDD interacts with PI3KC3 to activate autophagy and attenuate epithelial–mesenchymal transition in human breast cancer. Can Res 72(13):3238–3250CrossRef
Ma C, Nong K, Zhu H, Wang W, Huang X, Yuan Z, Ai K (2014) H19 promotes pancreatic cancer metastasis by derepressing let-7’s suppression on its target HMGA2-mediated EMT. Tumor Biology 35(9):9163–9169PubMedCrossRef
Ma M-z, Zhang Y, Weng M-z, Wang S-h, Hu Y, Hou Z-y, Qin Y-y, Gong W, Zhang Y-J, Kong X (2016) Long noncoding RNA GCASPC, a target of miR-17-3p, negatively regulates pyruvate carboxylase–dependent cell proliferation in gallbladder cancer. Can Res 76(18):5361–5371CrossRef
Ma J, Zhang F, Sun P (2020) miR-140–3p impedes the proliferation of human cervical cancer cells by targeting RRM2 to induce cell-cycle arrest and early apoptosis. Bioorg Med Chem 28(3):115283PubMedCrossRef
Macintosh RL, Timpson P, Thorburn J, Anderson KI, Thorburn A, Ryan KM (2012) Inhibition of autophagy impairs tumor cell invasion in an organotypic model. Cell Cycle 11(10):2022–2029PubMedPubMedCentralCrossRef
McAfee Q, Zhang Z, Samanta A, Levi SM, Ma X-H, Piao S, Lynch JP, Uehara T, Sepulveda AR, Davis LE (2012) Autophagy inhibitor Lys05 has single-agent antitumor activity and reproduces the phenotype of a genetic autophagy deficiency. Proc Natl Acad Sci 109(21):8253–8258PubMedPubMedCentralCrossRef
Meng Q, Dai M, Nie X, Zhang W, Xu X, Li J, Mu H, Liu X, Qin L, Zhu X (2018) MicroRNA-19 contributes to the malignant phenotypes of osteosarcoma in vitro by targeting Pax6. Tumor Biol 40(1):1010428317744704CrossRef
Micalizzi DS, Farabaugh SM, Ford HL (2010) Epithelial-mesenchymal transition in cancer: parallels between normal development and tumor progression. J Mammary Gland Biol Neoplasia 15(2):117–134PubMedPubMedCentralCrossRef
Mowers EE, Sharifi MN, Macleod KF (2017) Autophagy in cancer metastasis. Oncogene 36(12):1619–1630PubMedCrossRef
Niu S, Ma X, Zhang Y, Liu Y-N, Chen X, Gong H, Yao Y, Liu K, Zhang X (2018) MicroRNA-19a and microRNA-19b promote the malignancy of clear cell renal cell carcinoma through targeting the tumor suppressor RhoB. PLoS One 13(2):e0192790PubMedPubMedCentralCrossRef
O’Brien SJ, Bishop C, Hallion J, Fiechter C, Scheurlen K, Paas M, Burton J, Galandiuk S (2020) Long non-coding RNA (lncRNA) and epithelial-mesenchymal transition (EMT) in colorectal cancer: a systematic review. Cancer Biol Ther 21(9):769–781PubMedPubMedCentralCrossRef
Pan L-J, Zhong T-F, Tang R-X, Li P, Dang Y-W, Huang S-N, Chen G (2015) Upregulation and clinicopathological significance of long non-coding NEAT1 RNA in NSCLC tissues. Asian Pac J Cancer Prev 16(7):2851–2855PubMedCrossRef
Pang M, Wang H, Rao P, Zhao Y, Xie J, Cao Q, Wang Y, Wang YM, Lee VW, Alexander SI (2016) Autophagy links β-catenin and Smad signaling to promote epithelial-mesenchymal transition via upregulation of integrin linked kinase. Int J Biochem Cell Biol 76:123–134PubMedCrossRef
Pawar K, Hanisch C, Vera SEP, Einspanier R, Sharbati S (2016) Down regulated lncRNA MEG3 eliminates mycobacteria in macrophages via autophagy. Sci Rep 6(1):1–13CrossRef
Peng Y, Tang D, Zhao M, Kajiyama H, Kikkawa F, Kondo Y (2020) Long non-coding RNA: a recently accentuated molecule in chemoresistance in cancer. Cancer Metastasis Rev 39(3):825–835PubMedCrossRef
Qin W, Li C, Zheng W, Guo Q, Zhang Y, Kang M, Zhang B, Yang B, Li B, Yang H (2015) Inhibition of autophagy promotes metastasis and glycolysis by inducing ROS in gastric cancer cells. Oncotarget 6(37):39839PubMedPubMedCentralCrossRef
Qiu M, Liang Z, Chen L, Tan G, Wang K, Liu L, Liu J, Chen H (2015) MicroRNA-429 suppresses cell proliferation, epithelial-mesenchymal transition, and metastasis by direct targeting of BMI1 and E2F3 in renal cell carcinoma. Urologic oncology: seminars and original investigations, vol 7. Elsevier, Amsterdam, p 332. e339-332. e318
Rinn JL, Kertesz M, Wang JK, Squazzo SL, Xu X, Brugmann SA, Goodnough LH, Helms JA, Farnham PJ, Segal E (2007) Functional demarcation of active and silent chromatin domains in human HOX loci by noncoding RNAs. Cell 129(7):1311–1323PubMedPubMedCentralCrossRef
Saitoh M (2018) Involvement of partial EMT in cancer progression. J Biochemistry 164(4):257–264CrossRef
Sakimura S, Sugimachi K, Kurashige J, Ueda M, Hirata H, Nambara S, Komatsu H, Saito T, Takano Y, Uchi R (2015) The miR-506-induced epithelial–mesenchymal transition is involved in poor prognosis for patients with gastric cancer. Ann Surg Oncol 22(3):1436–1443CrossRef
Salameh A, Lee AK, Cardó-Vila M, Nunes DN, Efstathiou E, Staquicini FI, Dobroff AS, Marchiò S, Navone NM, Hosoya H (2015) PRUNE2 is a human prostate cancer suppressor regulated by the intronic long noncoding RNA PCA3. Proc Natl Acad Sci 112(27):8403–8408PubMedPubMedCentralCrossRef
Saleh T, Cuttino L (1860) Gewirtz DA (2016) Autophagy is not uniformly cytoprotective: a personalized medicine approach for autophagy inhibition as a therapeutic strategy in non-small cell lung cancer. Biochim Biophys Acta (BBA)-Gen Subj 10:2130–2136
Salminen A, Kaarniranta K, Kauppinen A (2016) AMPK and HIF signaling pathways regulate both longevity and cancer growth: the good news and the bad news about survival mechanisms. Biogerontology 17(4):655–680PubMedCrossRef
Sharifi MN, Mowers EE, Drake LE, Collier C, Chen H, Zamora M, Mui S, Macleod KF (2016) Autophagy promotes focal adhesion disassembly and cell motility of metastatic tumor cells through the direct interaction of paxillin with LC3. Cell Rep 15(8):1660–1672PubMedPubMedCentralCrossRef
Sharma U, Barwal TS, Acharya V, Tamang S, Vasquez KM, Jain A (2020) Cancer susceptibility candidate 9 (CASC9): a novel targetable long noncoding RNA in cancer treatment. Transl Oncol 13(8):100774PubMedPubMedCentralCrossRef
Shi Y, Yang Z, Zhang T, Shen L, Li Y, Ding S (2019) SIRT1-targeted miR-543 autophagy inhibition and epithelial–mesenchymal transition promotion in Helicobacter pylori CagA-associated gastric cancer. Cell Death Dis 10(9):1–14CrossRef
Singh SS, Vats S, Chia AY-Q, Tan TZ, Deng S, Ong MS, Arfuso F, Yap CT, Goh BC, Sethi G (2018) Dual role of autophagy in hallmarks of cancer. Oncogene 37(9):1142–1158PubMedCrossRef
Sørensen KP, Thomassen M, Tan Q, Bak M, Cold S, Burton M, Larsen MJ, Kruse TA (2013) Long non-coding RNA HOTAIR is an independent prognostic marker of metastasis in estrogen receptor-positive primary breast cancer. Breast Cancer Res Treat 142(3):529–536PubMedCrossRef
Streicher K, Zhu W, Lehmann K, Georgantas R, Morehouse C, Brohawn P, Carrasco R, Xiao Z, Tice D, Higgs B (2012) A novel oncogenic role for the miRNA-506-514 cluster in initiating melanocyte transformation and promoting melanoma growth. Oncogene 31(12):1558–1570PubMedCrossRef
Strohecker AM, Guo JY, Karsli-Uzunbas G, Price SM, Chen GJ, Mathew R, McMahon M, White E (2013) Autophagy sustains mitochondrial glutamine metabolism and growth of BrafV600E–driven lung tumors. Cancer Discov 3(11):1272–1285PubMedCrossRef
Su Z, Li G, Liu C, Ren S, Deng T, Zhang S, Tian Y, Liu Y, Qiu Y (2017) Autophagy inhibition impairs the epithelial-mesenchymal transition and enhances cisplatin sensitivity in nasopharyngeal carcinoma. Oncol Lett 13(6):4147–4154PubMedPubMedCentralCrossRef
Sui X, Chen R, Wang Z, Huang Z, Kong N, Zhang M, Han W, Lou F, Yang J, Zhang Q (2013) Autophagy and chemotherapy resistance: a promising therapeutic target for cancer treatment. Cell Death Dis 4(10):e838–e838PubMedPubMedCentralCrossRef
Sun J, Chu H, Ji J, Huo G, Song Q, Zhang X (2016) Long non-coding RNA HOTAIR modulates HLA-G expression by absorbing miR-148a in human cervical cancer. Int J Oncol 49(3):943–952PubMedCrossRef
Sun R, Liu Z, Han L, Yang Y, Wu F, Jiang Q, Zhang H, Ma R, Miao J, He K (2019) miR-22 and miR-214 targeting BCL9L inhibit proliferation, metastasis, and epithelial-mesenchymal transition by down-regulating Wnt signaling in colon cancer. FASEB J 33(4):5411–5424PubMedCrossRef
Takikawa T, Masamune A, Hamada S, Nakano E, Yoshida N, Shimosegawa T (2013) miR-210 regulates the interaction between pancreatic cancer cells and stellate cells. Biochem Biophys Res Commun 437(3):433–439PubMedCrossRef
Tan Y, Zeng Q, Bagniewska-Zadworna A, Vendelbo M, Paludan S, Jessen N, Andersen S, Møller A, Davey H, Chen G (2016) Erratum to: Guidelines for the use and interpretation of assays for monitoring autophagy (Autophagy, 12, 1, 1-222, 1100356). Autophagy 12(2):443–443. https://​doi.​org/​10.​1080/​15548627.​2015CrossRef
Tang X, Qiao X, Chen C, Liu Y, Zhu J, Liu J (2019) Regulation mechanism of long noncoding RNAs in colon cancer development and progression. Yonsei Med J 60(4):319–325PubMedPubMedCentralCrossRef
Tao J, Wu D, Xu B, Qian W, Li P, Lu Q, Yin C, Zhang W (2012) microRNA-133 inhibits cell proliferation, migration and invasion in prostate cancer cells by targeting the epidermal growth factor receptor. Oncol Rep 27(6):1967–1975PubMed
Thai P, Statt S, Chen CH, Liang E, Campbell C, Wu R (2013) Characterization of a novel long noncoding RNA, SCAL1, induced by cigarette smoke and elevated in lung cancer cell lines. Am J Respir Cell Mol Biol 49(2):204–211PubMedPubMedCentralCrossRef
Tian B, Li X, Kalita M, Widen SG, Yang J, Bhavnani SK, Dang B, Kudlicki A, Sinha M, Kong F (2015) Analysis of the TGFβ-induced program in primary airway epithelial cells shows essential role of NF-κB/RelA signaling network in type II epithelial mesenchymal transition. BMC Genom 16(1):1–23CrossRef
Tong H, Yin H, Hossain MA, Wang Y, Wu F, Dong X, Gao S, Zhan K, He W (2019) Starvation-induced autophagy promotes the invasion and migration of human bladder cancer cells via TGF-β1/Smad3-mediated epithelial-mesenchymal transition activation. J Cell Biochem 120(4):5118–5127PubMedCrossRef
Wang P, Zhang J, Zhang L, Zhu Z, Fan J, Chen L, Zhuang L, Luo J, Chen H, Liu L (2013) MicroRNA 23b regulates autophagy associated with radioresistance of pancreatic cancer cells. Gastroenterology 145(5):1133-1143. e1112PubMedCrossRef
Wang K, Liu C-Y, Zhou L-Y, Wang J-X, Wang M, Zhao B, Zhao W-K, Xu S-J, Fan L-H, Zhang X-J (2015) APF lncRNA regulates autophagy and myocardial infarction by targeting miR-188-3p. Nat Commun 6(1):1–11
Wang T-H, Yu C-C, Lin Y-S, Chen T-C, Yeh C-T, Liang K-H, Shieh T-M, Chen C-Y, Hsueh C (2016a) Long noncoding RNA CPS1-IT1 suppresses the metastasis of hepatocellular carcinoma by regulating HIF-1α activity and inhibiting epithelial-mesenchymal transition. Oncotarget 7(28):43588PubMedPubMedCentralCrossRef
Wang Y, Xue D, Li Y, Pan X, Zhang X, Kuang B, Zhou M, Li X, Xiong W, Li G (2016b) The long noncoding RNA MALAT-1 is a novel biomarker in various cancers: a meta-analysis based on the GEO database and literature. J Cancer 7(8):991PubMedPubMedCentralCrossRef
Wang H, Zhang Y, Wu Q, Wang Y-B, Wang W (2018) miR-16 mimics inhibit TGF-β1-induced epithelial-to-mesenchymal transition via activation of autophagy in non-small cell lung carcinoma cells. Oncol Rep 39(1):247–254PubMedCrossRef
Wang C-Z, Yan G-X, Dong D-S, Xin H, Liu Z-Y (2019a) LncRNA-ATB promotes autophagy by activating yes-associated protein and inducing autophagy-related protein 5 expression in hepatocellular carcinoma. World J Gastroenterol 25(35):5310PubMedPubMedCentralCrossRef
Wang D, Bao F, Teng Y, Li Q, Li J (2019b) MicroRNA-506-3p initiates mesenchymal-to-epithelial transition and suppresses autophagy in osteosarcoma cells by directly targeting SPHK1. Biosci Biotechnol Biochem 83(5):836–844PubMedCrossRef
Wang L, Cho KB, Li Y, Tao G, Xie Z, Guo B (2019c) Long noncoding RNA (lncRNA)-mediated competing endogenous RNA networks provide novel potential biomarkers and therapeutic targets for colorectal cancer. Int J Mol Sci 20(22):5758PubMedCentralCrossRef
Wang C, Shi Z, Hong Z, Pan J, Chen Z, Qiu C, Zhuang H, Zheng X (2020a) MicroRNA-1276 promotes colon cancer cell proliferation by negatively regulating LACTB. Cancer Manag Res 12:12185PubMedPubMedCentralCrossRef
Wang Z, Wang J, Wang K, Zhou Y, Wang J (2020b) LncRNA FEZF1-AS1 promoted chemoresistance, autophagy and epithelial-mesenchymal transition (EMT) through regulation of miR-25-3p/ITGB8 axis in prostate cancer. Eur Rev Med Pharmacol Sci 24:2281–2293PubMed
Wu Y, Yang L, Zhao J, Li C, Nie J, Liu F, Zhuo C, Zheng Y, Li B, Wang Z (2015) Nuclear-enriched abundant transcript 1 as a diagnostic and prognostic biomarker in colorectal cancer. Mol Cancer 14(1):1–12CrossRef
Xie C, Liu S, Wu B, Zhao Y, Chen B, Guo J, Qiu S, Cao Y-m (2020) miR-19 Promotes Cell Proliferation, Invasion, Migration, and EMT by Inhibiting SPRED2-mediated Autophagy in osteosarcoma cells. Cell Transplant 29:0963689720962460PubMedCentralCrossRef
Xiong H, Shen J, Chen Z, Yang J, Xie B, Jia Y, Jayasinghe U, Wang J, Zhao W, Xie S (2020) H19/let-7/Lin28 ceRNA network mediates autophagy inhibiting epithelial-mesenchymal transition in breast cancer. Int J Oncol 56(3):794–806 PubMed
Xu Z, Li Z, Wang W, Xia Y, He Z, Li B, Wang S, Huang X, Sun G, Xu J (2019) MIR-1265 regulates cellular proliferation and apoptosis by targeting calcium binding protein 39 in gastric cancer and thereby, impairing oncogenic autophagy. Cancer Lett 449:226–236PubMedCrossRef
Xu W, Yu M, Qin J, Luo Y, Zhong M (2020) LACTB regulates PIK3R3 to promote autophagy and inhibit EMT and proliferation through the PI3K/AKT/mTOR signaling pathway in colorectal cancer. Cancer Manag Res 12:5181PubMedPubMedCentralCrossRef
Yang Z, Zhou L, Wu L-M, Lai M-C, Xie H-Y, Zhang F, Zheng S-S (2011) Overexpression of long non-coding RNA HOTAIR predicts tumor recurrence in hepatocellular carcinoma patients following liver transplantation. Ann Surg Oncol 18(5):1243–1250PubMedCrossRef
Yang D, Sun Y, Hu L, Zheng H, Ji P, Pecot CV, Zhao Y, Reynolds S, Cheng H, Rupaimoole R (2013) Integrated analyses identify a master microRNA regulatory network for the mesenchymal subtype in serous ovarian cancer. Cancer Cell 23(2):186–199PubMedPubMedCentralCrossRef
Yang Z, Sun Q, Guo J, Wang S, Song G, Liu W, Liu M, Tang H (2019) GRSF1-mediated MIR-G-1 promotes malignant behavior and nuclear autophagy by directly upregulating TMED5 and LMNB1 in cervical cancer cells. Autophagy 15(4):668–685PubMedCrossRef
Yang Z, Bian E, Xu Y, Ji X, Tang F, Ma C, Wang H, Zhao B (2020) Meg3 induces EMT and invasion of glioma cells via autophagy. Onco Targets Ther 13:989PubMedPubMedCentralCrossRef
Yao D, Wang P, Zhang J, Fu L, Ouyang L, Wang J (2016) Deconvoluting the relationships between autophagy and metastasis for potential cancer therapy. Apoptosis 21(6):683–698PubMedCrossRef
Ye Z, Fang B, Pan J, Zhang N, Huang J, Xie C, Lou T, Cao Z (2017) miR-138 suppresses the proliferation, metastasis and autophagy of non-small cell lung cancer by targeting Sirt1. Oncol Rep 37(6):3244–3252PubMedPubMedCentralCrossRef
Ying L, Huang Y, Chen H, Wang Y, Xia L, Chen Y, Liu Y, Qiu F (2013) Downregulated MEG3 activates autophagy and increases cell proliferation in bladder cancer. Mol BioSyst 9(3):407–411PubMedCrossRef
You L, Jin S, Zhu L, Qian W (2017) Autophagy, autophagy-associated adaptive immune responses and its role in hematologic malignancies. Oncotarget 8(7):12374PubMedCrossRef
Yu X, Luo A, Liu Y, Wang S, Li Y, Shi W, Liu Z, Qu X (2015a) MiR-214 increases the sensitivity of breast cancer cells to tamoxifen and fulvestrant through inhibition of autophagy. Mol Cancer 14(1):1–16CrossRef
Yu Z, Zhang Y, Gao N, Wang X (2015b) Overexpression of miR-506 inhibits growth of osteosarcoma through Snail2. Am J Transl Res 7(12):2716PubMedPubMedCentral
Yu G, Jia Z, Dou Z (2017) miR-24-3p regulates bladder cancer cell proliferation, migration, invasion and autophagy by targeting DEDD. Oncol Rep 37(2):1123–1131PubMedCrossRef
Yuan J-h, Yang F, Wang F, Ma J-z, Guo Y-j, Tao Q-f, Liu F, Pan W, Wang T-t, Zhou C-c (2014) A long noncoding RNA activated by TGF-β promotes the invasion-metastasis cascade in hepatocellular carcinoma. Cancer Cell 25(5):666–681PubMedCrossRef
Yuan K-T, Li B-X, Yuan Y-J, Tan M, Tan J-F, Dai W-G, Feng W-D, Zuo J-D (2018) Deregulation of microRNA-375 inhibits proliferation and migration in gastric cancer in association with autophagy-mediated AKT/mTOR signaling pathways. Technol Cancer Res Treat 17:1533033818806499PubMedPubMedCentralCrossRef
Yue H, Yun Y, Gao R, Li G, Sang N (2015) Winter polycyclic aromatic hydrocarbon-bound particulate matter from peri-urban North China promotes lung cancer cell metastasis. Environ Sci Technol 49(24):14484–14493PubMedCrossRef
Yue B, Qiu S, Zhao S, Liu C, Zhang D, Yu F, Peng Z, Yan D (2016) LncRNA-ATB mediated E-cadherin repression promotes the progression of colon cancer and predicts poor prognosis. J Gastroenterol Hepatol 31(3):595–603PubMedCrossRef
Zhang X, Zhang Z, Xin Y (2017) Impairment of growth of gastric carcinoma by miR-133-mediated Her-2 inhibition, vol 36. Sage Publications LTD, London EC1Y 1SP, England, pp 8925–2015 (1 Olivers Yard, 55 City Road)
Zhang Q, Li X, Li X, Li X, Chen Z (2018a) Retracted: LncRNA H19 promotes epithelial-mesenchymal transition (EMT) by targeting miR-484 in human lung cancer cells. J Cell Biochem 119(6):4447–4457PubMedCrossRef
Zhang W, Yuan W, Song J, Wang S, Gu X (2018b) LncRNA CPS1-IT1 suppresses EMT and metastasis of colorectal cancer by inhibiting hypoxia-induced autophagy through inactivation of HIF-1α. Biochimie 144:21–27PubMedCrossRef
Zhang X, Li Z, Xuan Z, Xu P, Wang W, Chen Z, Wang S, Sun G, Xu J, Xu Z (2018c) Novel role of miR-133a-3p in repressing gastric cancer growth and metastasis via blocking autophagy-mediated glutaminolysis. J Exp Clin Cancer Res 37(1):1–22PubMedPubMedCentralCrossRef
Zhang QY, Men CJ, Ding XW (2019) Upregulation of microRNA-140-3p inhibits epithelial-mesenchymal transition, invasion, and metastasis of hepatocellular carcinoma through inactivation of the MAPK signaling pathway by targeting GRN. J Cell Biochem 120(9):14885–14898PubMedCrossRef
Zhang X-Z, Liu H, Chen S-R (2020) Mechanisms of long non-coding RNAs in cancers and their dynamic regulations. Cancers 12(5):1245PubMedCentralCrossRef
Zhao G-s, Gao Z-r, Zhang Q, Tang X-f, Lv Y-f, Zhang Z-s, Zhang Y, Tan Q-l, Peng D-b, Jiang D-m (2018) TSSC3 promotes autophagy via inactivating the Src-mediated PI3K/Akt/mTOR pathway to suppress tumorigenesis and metastasis in osteosarcoma, and predicts a favorable prognosis. J Exp Clin Cancer Res 37(1):1–17CrossRef
Zhen L, Yun-Hui L, Hong-Yu D, Jun M, Yi-Long Y (2016) Long noncoding RNA NEAT1 promotes glioma pathogenesis by regulating miR-449b-5p/c-Met axis. Tumor Biology 37(1):673–683PubMedCrossRef
Zheng H-T, Shi D-B, Wang Y-W, Li X-X, Xu Y, Tripathi P, Gu W-L, Cai G-X, Cai S-J (2014) High expression of lncRNA MALAT1 suggests a biomarker of poor prognosis in colorectal cancer. Int J Clin Exp Pathol 7(6):3174PubMedPubMedCentral
Zheng X, Zhang Y, Liu Y, Fang L, Li L, Sun J, Pan Z, Xin W, Huang P (2018) HIF-2α activated lncRNA NEAT1 promotes hepatocellular carcinoma cell invasion and metastasis by affecting the epithelial-mesenchymal transition. J Cell Biochem 119(4):3247–3256PubMedCrossRef
Zhou Y, Wu D, Tao J, Qu P, Zhou Z, Hou J (2013) MicroRNA-133 inhibits cell proliferation, migration and invasion by targeting epidermal growth factor receptor and its downstream effector proteins in bladder cancer. Scand J Urol 47(5):423–432PubMedCrossRef
Zhou Y, Wang B, Wang Y, Chen G, Lian Q, Wang H (2019) miR-140-3p inhibits breast cancer proliferation and migration by directly regulating the expression of tripartite motif 28. Oncol Lett 17(4):3835–3841PubMedPubMedCentral
Zhu H, Wang D, Zhang L, Xie X, Wu Y, Liu Y, Shao G, Su Z (2014) Upregulation of autophagy by hypoxia-inducible factor-1α promotes EMT and metastatic ability of CD133+ pancreatic cancer stem-like cells during intermittent hypoxia. Oncol Rep 32(3):935–942PubMedCrossRef
Metadaten
Titel
Regulatory effects of lncRNAs and miRNAs on the crosstalk between autophagy and EMT in cancer: a new era for cancer treatment
verfasst von
Lihui Si
Zecheng Yang
Lu Ding
Duoduo Zhang
Publikationsdatum
27.01.2022
Verlag
Springer Berlin Heidelberg
Erschienen in
Journal of Cancer Research and Clinical Oncology / Ausgabe 3/2022
Print ISSN: 0171-5216
Elektronische ISSN: 1432-1335
DOI
https://doi.org/10.1007/s00432-021-03892-0

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