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Cancer Immunology, Immunotherapy

Erschienen in:

17.08.2018 | Review

Regulatory mechanisms of PD-L1 expression in cancer cells

verfasst von: Yongyu Shi

Erschienen in: Cancer Immunology, Immunotherapy | Ausgabe 10/2018

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Abstract

Immunotherapy targeting the PD-L1/PD-1 pathway using antibodies is effective in the clinical treatment of a multitude of cancers. This makes research of the regulatory mechanisms of PD-1 expression in cancer cells intriguing. PD-L1 expression can be categorized into inducible expression, attributed to extrinsic factors in the microenvironment, and constitutive expression, attributed to intrinsic cancer-driving gene alteration. The mechanisms of PD-L1 expression in cancer cells operate at multiple levels, including gene amplification, chromatin modification, transcription, posttranscription, translation and posttranslation. Moreover, some open questions in this field that need to be answered in future research are proposed. Studies of regulatory mechanisms of PD-L1 expression pave the way for the application of more effective approaches in the future of cancer immunotherapy.

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Titel: Regulatory mechanisms of PD-L1 expression in cancer cells
verfasst von: Yongyu Shi
Publikationsdatum: 17.08.2018
Verlag: Springer Berlin Heidelberg
Erschienen in: Cancer Immunology, Immunotherapy / Ausgabe 10/2018
Print ISSN: 0340-7004
Elektronische ISSN: 1432-0851
DOI: https://doi.org/10.1007/s00262-018-2226-9

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Regulatory mechanisms of PD-L1 expression in cancer cells

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