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01.01.2012 | Original Contribution

Regulatory T cells ameliorate cardiac remodeling after myocardial infarction

verfasst von: Ting-Ting Tang, Jing Yuan, Zheng-Feng Zhu, Wen-Cai Zhang, Hong Xiao, Ni Xia, Xin-Xin Yan, Shao-Fang Nie, Juan Liu, Su-Feng Zhou, Jing-Jing Li, Rui Yao, Meng-Yang Liao, Xin Tu, Yu-Hua Liao, Xiang Cheng

Erschienen in: Basic Research in Cardiology | Ausgabe 1/2012

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Abstract

Persistent inflammatory responses participate in the pathogenesis of adverse ventricular remodeling after myocardial infarction (MI). We hypothesized that regulatory T (Treg) cells modulate inflammatory responses, attenuate ventricular remodeling and subsequently improve cardiac function after MI. Acute MI was induced by ligation of the left anterior descending coronary artery in rats. Infiltration of Foxp3⁺ Treg cells was detected in the infarcted heart. Expansion of Treg cells in vivo by means of adoptive transfer as well as a CD28 superagonistic antibody (JJ316) resulted in an increased number of Foxp3⁺ Treg cells in the infarcted heart. Subsequently, rats with MI showed improved cardiac function following Treg cells transfer or JJ316 injection. Interstitial fibrosis, myocardial matrix metalloproteinase-2 activity and cardiac apoptosis were attenuated in the rats that received Treg cells transfer. Infiltration of neutrophils, macrophages and lymphocytes as well as expression of tumor necrosis factor (TNF)-α and interleukin (IL)-1β were also significantly decreased, and the CD8⁺ cardiac-specific cytotoxic T lymphocyte response was inhibited. Expression of interleukin (IL)-10 in the heart, however, was increased. Additional studies in vitro indicated that Treg cells directly protect neonatal rat cardiomyocytes against LPS-induced apoptosis, and this protection depends on the cell–cell contact and IL-10 expression. Furthermore, Treg cells inhibited proinflammatory cytokines production by cardiomyocytes. These data demonstrate that Treg cells serve to protect against adverse ventricular remodeling and contribute to improve cardiac function after myocardial infarction via inhibition of inflammation and direct protection of cardiomyocytes.

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Titel: Regulatory T cells ameliorate cardiac remodeling after myocardial infarction
verfasst von: Ting-Ting Tang
Jing Yuan
Zheng-Feng Zhu
Wen-Cai Zhang
Hong Xiao
Ni Xia
Xin-Xin Yan
Shao-Fang Nie
Juan Liu
Su-Feng Zhou
Jing-Jing Li
Rui Yao
Meng-Yang Liao
Xin Tu
Yu-Hua Liao
Xiang Cheng
Publikationsdatum: 01.01.2012
Verlag: Springer-Verlag
Erschienen in: Basic Research in Cardiology / Ausgabe 1/2012
Print ISSN: 0300-8428
Elektronische ISSN: 1435-1803
DOI: https://doi.org/10.1007/s00395-011-0232-6

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